METHOD FOR DETERMINING THE ACTIVITY OF TRANSGLUTAMINASE FACTOR XIIIA

Die vorliegende Erfindung betrifft ein UV/VIS- oder fluoreszenzbasierendes Verfahren zur qualitativen und quantitativen Bestimmung der Aktivität des Blutgerinnungsfaktors XIIIa, bzw. des Gehalts an Zymogen Faktor XIII, welches zu Faktor XIIIa aktiviert wird, unter Verwendung neuer chromogener oder f...

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Hauptverfasser:	HAMMAMY, M., ZOUHIR, BECKER, GERO, HARDES, KORNELIA, STEINMETZER, TORSTEN
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS TESTING VINEGAR WINE
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creator	HAMMAMY, M., ZOUHIR BECKER, GERO HARDES, KORNELIA STEINMETZER, TORSTEN
description	Die vorliegende Erfindung betrifft ein UV/VIS- oder fluoreszenzbasierendes Verfahren zur qualitativen und quantitativen Bestimmung der Aktivität des Blutgerinnungsfaktors XIIIa, bzw. des Gehalts an Zymogen Faktor XIII, welches zu Faktor XIIIa aktiviert wird, unter Verwendung neuer chromogener oder fluoreszenzmarkierter Peptidsubstrate sowie die Verwendung solcher Verfahren und/oder Substrate in Screeningassays. Die erfindungsgemäßen Peptidsubstrate können optional ein Quencher-/Donor-Paar enthalten. The invention relates to a UV/Vis or fluorescence-based method for qualitatively and quantitatively determining the activity of blood coagulation factor XIIIa or the content of the zymogen, factor XIII, which is activated to form factor XIIIa, using novel chromogenic or fluorescence-labeled peptide substrates and to the use of such methods and/or substrates in screening assays. The peptide substrates according to the invention can optionally contain a quencher/donor pair. La présente invention concerne un procédé UV/VIS ou à base de fluorescence permettant de déterminer qualitativement et quantitativement l'activité du facteur XIIIa de coagulation sanguine, ou la teneur en facteur XIII zymogène qui est activé en facteur XIIIa, en utilisant de nouveaux substrats peptidiques chromogènes ou à marquage fluorescent ainsi que l'utilisation de ces procédés et/ou substrats dans des essais de dépistage. Les substrats peptidiques selon l'invention peuvent contenir en option une paire désactiveur/donneur.
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Die erfindungsgemäßen Peptidsubstrate können optional ein Quencher-/Donor-Paar enthalten. The invention relates to a UV/Vis or fluorescence-based method for qualitatively and quantitatively determining the activity of blood coagulation factor XIIIa or the content of the zymogen, factor XIII, which is activated to form factor XIIIa, using novel chromogenic or fluorescence-labeled peptide substrates and to the use of such methods and/or substrates in screening assays. The peptide substrates according to the invention can optionally contain a quencher/donor pair. La présente invention concerne un procédé UV/VIS ou à base de fluorescence permettant de déterminer qualitativement et quantitativement l'activité du facteur XIIIa de coagulation sanguine, ou la teneur en facteur XIII zymogène qui est activé en facteur XIIIa, en utilisant de nouveaux substrats peptidiques chromogènes ou à marquage fluorescent ainsi que l'utilisation de ces procédés et/ou substrats dans des essais de dépistage. 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Die erfindungsgemäßen Peptidsubstrate können optional ein Quencher-/Donor-Paar enthalten. The invention relates to a UV/Vis or fluorescence-based method for qualitatively and quantitatively determining the activity of blood coagulation factor XIIIa or the content of the zymogen, factor XIII, which is activated to form factor XIIIa, using novel chromogenic or fluorescence-labeled peptide substrates and to the use of such methods and/or substrates in screening assays. The peptide substrates according to the invention can optionally contain a quencher/donor pair. La présente invention concerne un procédé UV/VIS ou à base de fluorescence permettant de déterminer qualitativement et quantitativement l'activité du facteur XIIIa de coagulation sanguine, ou la teneur en facteur XIII zymogène qui est activé en facteur XIIIa, en utilisant de nouveaux substrats peptidiques chromogènes ou à marquage fluorescent ainsi que l'utilisation de ces procédés et/ou substrats dans des essais de dépistage. 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Die erfindungsgemäßen Peptidsubstrate können optional ein Quencher-/Donor-Paar enthalten. The invention relates to a UV/Vis or fluorescence-based method for qualitatively and quantitatively determining the activity of blood coagulation factor XIIIa or the content of the zymogen, factor XIII, which is activated to form factor XIIIa, using novel chromogenic or fluorescence-labeled peptide substrates and to the use of such methods and/or substrates in screening assays. The peptide substrates according to the invention can optionally contain a quencher/donor pair. La présente invention concerne un procédé UV/VIS ou à base de fluorescence permettant de déterminer qualitativement et quantitativement l'activité du facteur XIIIa de coagulation sanguine, ou la teneur en facteur XIII zymogène qui est activé en facteur XIIIa, en utilisant de nouveaux substrats peptidiques chromogènes ou à marquage fluorescent ainsi que l'utilisation de ces procédés et/ou substrats dans des essais de dépistage. Les substrats peptidiques selon l'invention peuvent contenir en option une paire désactiveur/donneur.</abstract><oa>free_for_read</oa></addata></record>
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subjects	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS TESTING VINEGAR WINE
title	METHOD FOR DETERMINING THE ACTIVITY OF TRANSGLUTAMINASE FACTOR XIIIA
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