IMPROVED BIOREACTOR PERFORMANCE IN THE PRODUCTION OF MONATIN
Methods and systems for increasing the production of monatin in a multi-step equilibrium pathway are described. Tryptophan and pyruvate are added to a bioreactor to form a mixture comprising monatin and a plurality of intermediates via a multi-step equilibrium pathway. The methods and systems includ...
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| creator | PORTER, MICHAEL A RASMUSSEN, MARIBETH PEMBLE, TRENT MARASCO, ERIN SOLHEID, CHRISTOPHER |
| description | Methods and systems for increasing the production of monatin in a multi-step equilibrium pathway are described. Tryptophan and pyruvate are added to a bioreactor to form a mixture comprising monatin and a plurality of intermediates via a multi-step equilibrium pathway. The methods and systems include operating the bioreactor such that a temperature of the mixture in the bioreactor is less than 25 degrees Celsius, resulting in an increased production of monatin. In some embodiments, the temperature of the mixture in the bioreactor is between about 5 degrees Celsius and about 23 degrees Celsius; in other embodiments, the temperature is between about 10 degrees Celsius and about 18 degrees Celsius.
L'invention concerne des procédés et des systèmes pour augmenter la production de monatine dans une voie d'équilibre multi-étapes. Du tryptophane et du pyruvate sont ajoutés à un bioréacteur pour former un mélange comprenant de la monatine et une pluralité d'intermédiaires par une voie d'équilibre multi-étapes. Les procédés et les systèmes comprennent le fonctionnement du bioréacteur de telle sorte qu'une température du mélange dans le bioréacteur est inférieure à 25 degrés Celsius, conduisant à une production accrue de monatine. Dans certains modes de réalisation, la température du mélange dans le bioréacteur est entre environ 5 degrés Celsius et environ 23 degrés Celsius; dans d'autres modes de réalisation, la température se situe entre environ 10 degrés Celsius et environ 18 degrés Celsius. |
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L'invention concerne des procédés et des systèmes pour augmenter la production de monatine dans une voie d'équilibre multi-étapes. Du tryptophane et du pyruvate sont ajoutés à un bioréacteur pour former un mélange comprenant de la monatine et une pluralité d'intermédiaires par une voie d'équilibre multi-étapes. Les procédés et les systèmes comprennent le fonctionnement du bioréacteur de telle sorte qu'une température du mélange dans le bioréacteur est inférieure à 25 degrés Celsius, conduisant à une production accrue de monatine. Dans certains modes de réalisation, la température du mélange dans le bioréacteur est entre environ 5 degrés Celsius et environ 23 degrés Celsius; dans d'autres modes de réalisation, la température se situe entre environ 10 degrés Celsius et environ 18 degrés Celsius.</description><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; ENZYMOLOGY ; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE ; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC ; GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS ; METALLURGY ; MICROBIOLOGY ; MUTATION OR GENETIC ENGINEERING ; REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGYGENERATION, TRANSMISSION OR DISTRIBUTION ; SPIRITS ; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS ; TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE ; VINEGAR ; WINE</subject><creationdate>2011</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20110707&DB=EPODOC&CC=WO&NR=2011082365A2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20110707&DB=EPODOC&CC=WO&NR=2011082365A2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>PORTER, MICHAEL A</creatorcontrib><creatorcontrib>RASMUSSEN, MARIBETH</creatorcontrib><creatorcontrib>PEMBLE, TRENT</creatorcontrib><creatorcontrib>MARASCO, ERIN</creatorcontrib><creatorcontrib>SOLHEID, CHRISTOPHER</creatorcontrib><title>IMPROVED BIOREACTOR PERFORMANCE IN THE PRODUCTION OF MONATIN</title><description>Methods and systems for increasing the production of monatin in a multi-step equilibrium pathway are described. Tryptophan and pyruvate are added to a bioreactor to form a mixture comprising monatin and a plurality of intermediates via a multi-step equilibrium pathway. The methods and systems include operating the bioreactor such that a temperature of the mixture in the bioreactor is less than 25 degrees Celsius, resulting in an increased production of monatin. In some embodiments, the temperature of the mixture in the bioreactor is between about 5 degrees Celsius and about 23 degrees Celsius; in other embodiments, the temperature is between about 10 degrees Celsius and about 18 degrees Celsius.
L'invention concerne des procédés et des systèmes pour augmenter la production de monatine dans une voie d'équilibre multi-étapes. Du tryptophane et du pyruvate sont ajoutés à un bioréacteur pour former un mélange comprenant de la monatine et une pluralité d'intermédiaires par une voie d'équilibre multi-étapes. Les procédés et les systèmes comprennent le fonctionnement du bioréacteur de telle sorte qu'une température du mélange dans le bioréacteur est inférieure à 25 degrés Celsius, conduisant à une production accrue de monatine. Dans certains modes de réalisation, la température du mélange dans le bioréacteur est entre environ 5 degrés Celsius et environ 23 degrés Celsius; dans d'autres modes de réalisation, la température se situe entre environ 10 degrés Celsius et environ 18 degrés Celsius.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>ENZYMOLOGY</subject><subject>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</subject><subject>GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC</subject><subject>GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGYGENERATION, TRANSMISSION OR DISTRIBUTION</subject><subject>SPIRITS</subject><subject>TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS</subject><subject>TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2011</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLDx9A0I8g9zdVFw8vQPcnV0DvEPUghwDXLzD_J19HN2VfD0UwjxcFUAKnIJdQ7x9PdT8HdT8PX3cwzx9ONhYE1LzClO5YXS3AzKbq4hzh66qQX58anFBYnJqXmpJfHh_kYGhoYGFkbGZqaORsbEqQIAvzsqmQ</recordid><startdate>20110707</startdate><enddate>20110707</enddate><creator>PORTER, MICHAEL A</creator><creator>RASMUSSEN, MARIBETH</creator><creator>PEMBLE, TRENT</creator><creator>MARASCO, ERIN</creator><creator>SOLHEID, CHRISTOPHER</creator><scope>EVB</scope></search><sort><creationdate>20110707</creationdate><title>IMPROVED BIOREACTOR PERFORMANCE IN THE PRODUCTION OF MONATIN</title><author>PORTER, MICHAEL A ; RASMUSSEN, MARIBETH ; PEMBLE, TRENT ; MARASCO, ERIN ; SOLHEID, CHRISTOPHER</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2011082365A23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2011</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>ENZYMOLOGY</topic><topic>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</topic><topic>GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC</topic><topic>GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGYGENERATION, TRANSMISSION OR DISTRIBUTION</topic><topic>SPIRITS</topic><topic>TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS</topic><topic>TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>PORTER, MICHAEL A</creatorcontrib><creatorcontrib>RASMUSSEN, MARIBETH</creatorcontrib><creatorcontrib>PEMBLE, TRENT</creatorcontrib><creatorcontrib>MARASCO, ERIN</creatorcontrib><creatorcontrib>SOLHEID, CHRISTOPHER</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>PORTER, MICHAEL A</au><au>RASMUSSEN, MARIBETH</au><au>PEMBLE, TRENT</au><au>MARASCO, ERIN</au><au>SOLHEID, CHRISTOPHER</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>IMPROVED BIOREACTOR PERFORMANCE IN THE PRODUCTION OF MONATIN</title><date>2011-07-07</date><risdate>2011</risdate><abstract>Methods and systems for increasing the production of monatin in a multi-step equilibrium pathway are described. Tryptophan and pyruvate are added to a bioreactor to form a mixture comprising monatin and a plurality of intermediates via a multi-step equilibrium pathway. The methods and systems include operating the bioreactor such that a temperature of the mixture in the bioreactor is less than 25 degrees Celsius, resulting in an increased production of monatin. In some embodiments, the temperature of the mixture in the bioreactor is between about 5 degrees Celsius and about 23 degrees Celsius; in other embodiments, the temperature is between about 10 degrees Celsius and about 18 degrees Celsius.
L'invention concerne des procédés et des systèmes pour augmenter la production de monatine dans une voie d'équilibre multi-étapes. Du tryptophane et du pyruvate sont ajoutés à un bioréacteur pour former un mélange comprenant de la monatine et une pluralité d'intermédiaires par une voie d'équilibre multi-étapes. Les procédés et les systèmes comprennent le fonctionnement du bioréacteur de telle sorte qu'une température du mélange dans le bioréacteur est inférieure à 25 degrés Celsius, conduisant à une production accrue de monatine. Dans certains modes de réalisation, la température du mélange dans le bioréacteur est entre environ 5 degrés Celsius et environ 23 degrés Celsius; dans d'autres modes de réalisation, la température se situe entre environ 10 degrés Celsius et environ 18 degrés Celsius.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGYGENERATION, TRANSMISSION OR DISTRIBUTION SPIRITS TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE VINEGAR WINE |
| title | IMPROVED BIOREACTOR PERFORMANCE IN THE PRODUCTION OF MONATIN |
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