PRODUCTION PROCESS FOR CEPHRADINE
The invention relates to a process for preparing cephradine, said process comprising converting D-dihydrophenylglycine (DHPG) into an activated form (DHPGa); and reacting 7-aminodesacetoxy-cephalosporanic acid (7-ADCA) with D- dihydrophenylglycine in activated form (DHPGa) in the presence of an enzy...
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| creator | DOOREN, VAN, THEODORUS, JOHANNES, GODFRIED, MARIA MOODY, HAROLD, MONRO |
| description | The invention relates to a process for preparing cephradine, said process comprising converting D-dihydrophenylglycine (DHPG) into an activated form (DHPGa); and reacting 7-aminodesacetoxy-cephalosporanic acid (7-ADCA) with D- dihydrophenylglycine in activated form (DHPGa) in the presence of an enzyme in an aqueous reaction mixture to form cephradine characterized in that at least step (a) and step (b) of the process are carried out under anaerobic conditions.
L'invention concerne un procédé de préparation de céphradine, ledit procédé consistant à convertir de la D-dihydrophénylglycine (DHPG) en une forme activée (DHPGa); et à faire réagir de l'acide 7-aminodésacétoxy-céphalosporanique (7-ADCA) avec de la D- dihydrophénylglycine sous forme activée (DHPGa) en présence d'une enzyme dans un mélange réactionnel aqueux pour former de la céphradine. Le procédé est caractérisé en ce qu'au moins une étape (a) et une étape (b) sont mises en oeuvre dans des conditions anaérobies. |
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L'invention concerne un procédé de préparation de céphradine, ledit procédé consistant à convertir de la D-dihydrophénylglycine (DHPG) en une forme activée (DHPGa); et à faire réagir de l'acide 7-aminodésacétoxy-céphalosporanique (7-ADCA) avec de la D- dihydrophénylglycine sous forme activée (DHPGa) en présence d'une enzyme dans un mélange réactionnel aqueux pour former de la céphradine. Le procédé est caractérisé en ce qu'au moins une étape (a) et une étape (b) sont mises en oeuvre dans des conditions anaérobies.</description><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; ENZYMES ; ENZYMOLOGY ; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE ; METALLURGY ; MICROBIOLOGY ; MUTATION OR GENETIC ENGINEERING ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2011</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20110623&DB=EPODOC&CC=WO&NR=2011073166A2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76294</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20110623&DB=EPODOC&CC=WO&NR=2011073166A2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>DOOREN, VAN, THEODORUS, JOHANNES, GODFRIED, MARIA</creatorcontrib><creatorcontrib>MOODY, HAROLD, MONRO</creatorcontrib><title>PRODUCTION PROCESS FOR CEPHRADINE</title><description>The invention relates to a process for preparing cephradine, said process comprising converting D-dihydrophenylglycine (DHPG) into an activated form (DHPGa); and reacting 7-aminodesacetoxy-cephalosporanic acid (7-ADCA) with D- dihydrophenylglycine in activated form (DHPGa) in the presence of an enzyme in an aqueous reaction mixture to form cephradine characterized in that at least step (a) and step (b) of the process are carried out under anaerobic conditions.
L'invention concerne un procédé de préparation de céphradine, ledit procédé consistant à convertir de la D-dihydrophénylglycine (DHPG) en une forme activée (DHPGa); et à faire réagir de l'acide 7-aminodésacétoxy-céphalosporanique (7-ADCA) avec de la D- dihydrophénylglycine sous forme activée (DHPGa) en présence d'une enzyme dans un mélange réactionnel aqueux pour former de la céphradine. Le procédé est caractérisé en ce qu'au moins une étape (a) et une étape (b) sont mises en oeuvre dans des conditions anaérobies.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>ENZYMES</subject><subject>ENZYMOLOGY</subject><subject>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2011</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFAMCPJ3CXUO8fT3UwAynV2DgxXc_IMUnF0DPIIcXTz9XHkYWNMSc4pTeaE0N4Oym2uIs4duakF-fGpxQWJyal5qSXy4v5GBoaGBubGhmZmjkTFxqgCu2CMw</recordid><startdate>20110623</startdate><enddate>20110623</enddate><creator>DOOREN, VAN, THEODORUS, JOHANNES, GODFRIED, MARIA</creator><creator>MOODY, HAROLD, MONRO</creator><scope>EVB</scope></search><sort><creationdate>20110623</creationdate><title>PRODUCTION PROCESS FOR CEPHRADINE</title><author>DOOREN, VAN, THEODORUS, JOHANNES, GODFRIED, MARIA ; MOODY, HAROLD, MONRO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2011073166A23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2011</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>ENZYMES</topic><topic>ENZYMOLOGY</topic><topic>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>DOOREN, VAN, THEODORUS, JOHANNES, GODFRIED, MARIA</creatorcontrib><creatorcontrib>MOODY, HAROLD, MONRO</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>DOOREN, VAN, THEODORUS, JOHANNES, GODFRIED, MARIA</au><au>MOODY, HAROLD, MONRO</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PRODUCTION PROCESS FOR CEPHRADINE</title><date>2011-06-23</date><risdate>2011</risdate><abstract>The invention relates to a process for preparing cephradine, said process comprising converting D-dihydrophenylglycine (DHPG) into an activated form (DHPGa); and reacting 7-aminodesacetoxy-cephalosporanic acid (7-ADCA) with D- dihydrophenylglycine in activated form (DHPGa) in the presence of an enzyme in an aqueous reaction mixture to form cephradine characterized in that at least step (a) and step (b) of the process are carried out under anaerobic conditions.
L'invention concerne un procédé de préparation de céphradine, ledit procédé consistant à convertir de la D-dihydrophénylglycine (DHPG) en une forme activée (DHPGa); et à faire réagir de l'acide 7-aminodésacétoxy-céphalosporanique (7-ADCA) avec de la D- dihydrophénylglycine sous forme activée (DHPGa) en présence d'une enzyme dans un mélange réactionnel aqueux pour former de la céphradine. Le procédé est caractérisé en ce qu'au moins une étape (a) et une étape (b) sont mises en oeuvre dans des conditions anaérobies.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY ENZYMES ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING SPIRITS VINEGAR WINE |
| title | PRODUCTION PROCESS FOR CEPHRADINE |
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