PROCESSES FOR PREPARING CRYSTALLINE FORMS A AND B OF ILAPRAZOLE AND PROCESS FOR CONVERTING THE CRYSTALLINE FORMS
Disclosed are novel processes for preparing crystalline forms A and B of ilaprazole of formula 1 and the conversion of these crystalline forms. The novel processes include a process of preparing the crystalline form A of high purity by preparing an inorganic salt of ilaprazole or a hydrate thereof a...
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| creator | PARK, SUNG TAE KIM, HEE YUN KIM, JUNG WOO LEE, JUN YEOUN SHIN, JAE SOO CHO, KWI HYUNG NAM, SANG DON KIM, DONG YEON |
| description | Disclosed are novel processes for preparing crystalline forms A and B of ilaprazole of formula 1 and the conversion of these crystalline forms. The novel processes include a process of preparing the crystalline form A of high purity by preparing an inorganic salt of ilaprazole or a hydrate thereof and then neutralizing the prepared inorganic salt of ilaprazole or the hydrate thereof with an acid in an organic solvent (single solvent or mixed solvent) a process of preparing the crystalline form B of high purity by removing impurities from ilaprazole using an organic solvent (single solvent or mixed solvent); and a process of conversion from the crystalline A into the crystalline form B or from the crystalline form B into the crystalline form A.
L'invention concerne de nouveaux procédés pour la préparation des formes cristallines A et B d'ilaprazole de formule 1 et la conversion de ces formes cristallines. Les nouveaux procédés comprennent un procédé de préparation de la forme cristalline A d'une pureté élevée par la préparation d'un sel inorganique d'ilaprazole ou d'un hydrate de celui-ci, puis la neutralisation du sel inorganique d'ilaprazole préparé ou de l'hydrate de celui-ci par un acide dans un solvant organique (solvant unique ou solvant mixte), un procédé de préparation de la forme cristalline B de pureté élevée par l'élimination des impuretés de l'ilaprazole à l'aide d'un solvant organique (solvant unique ou solvant mixte) ; et un procédé de conversion de la forme cristalline A en la forme cristalline B ou de la forme cristalline B en la forme cristalline A. |
| format | Patent |
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L'invention concerne de nouveaux procédés pour la préparation des formes cristallines A et B d'ilaprazole de formule 1 et la conversion de ces formes cristallines. Les nouveaux procédés comprennent un procédé de préparation de la forme cristalline A d'une pureté élevée par la préparation d'un sel inorganique d'ilaprazole ou d'un hydrate de celui-ci, puis la neutralisation du sel inorganique d'ilaprazole préparé ou de l'hydrate de celui-ci par un acide dans un solvant organique (solvant unique ou solvant mixte), un procédé de préparation de la forme cristalline B de pureté élevée par l'élimination des impuretés de l'ilaprazole à l'aide d'un solvant organique (solvant unique ou solvant mixte) ; et un procédé de conversion de la forme cristalline A en la forme cristalline B ou de la forme cristalline B en la forme cristalline A.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2011</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20111110&DB=EPODOC&CC=WO&NR=2011071314A3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20111110&DB=EPODOC&CC=WO&NR=2011071314A3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>PARK, SUNG TAE</creatorcontrib><creatorcontrib>KIM, HEE YUN</creatorcontrib><creatorcontrib>KIM, JUNG WOO</creatorcontrib><creatorcontrib>LEE, JUN YEOUN</creatorcontrib><creatorcontrib>SHIN, JAE SOO</creatorcontrib><creatorcontrib>CHO, KWI HYUNG</creatorcontrib><creatorcontrib>NAM, SANG DON</creatorcontrib><creatorcontrib>KIM, DONG YEON</creatorcontrib><title>PROCESSES FOR PREPARING CRYSTALLINE FORMS A AND B OF ILAPRAZOLE AND PROCESS FOR CONVERTING THE CRYSTALLINE FORMS</title><description>Disclosed are novel processes for preparing crystalline forms A and B of ilaprazole of formula 1 and the conversion of these crystalline forms. The novel processes include a process of preparing the crystalline form A of high purity by preparing an inorganic salt of ilaprazole or a hydrate thereof and then neutralizing the prepared inorganic salt of ilaprazole or the hydrate thereof with an acid in an organic solvent (single solvent or mixed solvent) a process of preparing the crystalline form B of high purity by removing impurities from ilaprazole using an organic solvent (single solvent or mixed solvent); and a process of conversion from the crystalline A into the crystalline form B or from the crystalline form B into the crystalline form A.
L'invention concerne de nouveaux procédés pour la préparation des formes cristallines A et B d'ilaprazole de formule 1 et la conversion de ces formes cristallines. Les nouveaux procédés comprennent un procédé de préparation de la forme cristalline A d'une pureté élevée par la préparation d'un sel inorganique d'ilaprazole ou d'un hydrate de celui-ci, puis la neutralisation du sel inorganique d'ilaprazole préparé ou de l'hydrate de celui-ci par un acide dans un solvant organique (solvant unique ou solvant mixte), un procédé de préparation de la forme cristalline B de pureté élevée par l'élimination des impuretés de l'ilaprazole à l'aide d'un solvant organique (solvant unique ou solvant mixte) ; et un procédé de conversion de la forme cristalline A en la forme cristalline B ou de la forme cristalline B en la forme cristalline A.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2011</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZCgICPJ3dg0Odg1WcPMPUggIcg1wDPL0c1dwDooMDnH08fH0cwXJ-AYrOCo4-rkoOCn4uyl4-jgGBDlG-fu4gsWgZoBNcPb3C3MNCgEZEeLhimkMDwNrWmJOcSovlOZmUHZzDXH20E0tyI9PLS5ITE7NSy2JD_c3MjA0NDA3NDY0cTQ2Jk4VALbCOLI</recordid><startdate>20111110</startdate><enddate>20111110</enddate><creator>PARK, SUNG TAE</creator><creator>KIM, HEE YUN</creator><creator>KIM, JUNG WOO</creator><creator>LEE, JUN YEOUN</creator><creator>SHIN, JAE SOO</creator><creator>CHO, KWI HYUNG</creator><creator>NAM, SANG DON</creator><creator>KIM, DONG YEON</creator><scope>EVB</scope></search><sort><creationdate>20111110</creationdate><title>PROCESSES FOR PREPARING CRYSTALLINE FORMS A AND B OF ILAPRAZOLE AND PROCESS FOR CONVERTING THE CRYSTALLINE FORMS</title><author>PARK, SUNG TAE ; KIM, HEE YUN ; KIM, JUNG WOO ; LEE, JUN YEOUN ; SHIN, JAE SOO ; CHO, KWI HYUNG ; NAM, SANG DON ; KIM, DONG YEON</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2011071314A33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2011</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>PARK, SUNG TAE</creatorcontrib><creatorcontrib>KIM, HEE YUN</creatorcontrib><creatorcontrib>KIM, JUNG WOO</creatorcontrib><creatorcontrib>LEE, JUN YEOUN</creatorcontrib><creatorcontrib>SHIN, JAE SOO</creatorcontrib><creatorcontrib>CHO, KWI HYUNG</creatorcontrib><creatorcontrib>NAM, SANG DON</creatorcontrib><creatorcontrib>KIM, DONG YEON</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>PARK, SUNG TAE</au><au>KIM, HEE YUN</au><au>KIM, JUNG WOO</au><au>LEE, JUN YEOUN</au><au>SHIN, JAE SOO</au><au>CHO, KWI HYUNG</au><au>NAM, SANG DON</au><au>KIM, DONG YEON</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PROCESSES FOR PREPARING CRYSTALLINE FORMS A AND B OF ILAPRAZOLE AND PROCESS FOR CONVERTING THE CRYSTALLINE FORMS</title><date>2011-11-10</date><risdate>2011</risdate><abstract>Disclosed are novel processes for preparing crystalline forms A and B of ilaprazole of formula 1 and the conversion of these crystalline forms. The novel processes include a process of preparing the crystalline form A of high purity by preparing an inorganic salt of ilaprazole or a hydrate thereof and then neutralizing the prepared inorganic salt of ilaprazole or the hydrate thereof with an acid in an organic solvent (single solvent or mixed solvent) a process of preparing the crystalline form B of high purity by removing impurities from ilaprazole using an organic solvent (single solvent or mixed solvent); and a process of conversion from the crystalline A into the crystalline form B or from the crystalline form B into the crystalline form A.
L'invention concerne de nouveaux procédés pour la préparation des formes cristallines A et B d'ilaprazole de formule 1 et la conversion de ces formes cristallines. Les nouveaux procédés comprennent un procédé de préparation de la forme cristalline A d'une pureté élevée par la préparation d'un sel inorganique d'ilaprazole ou d'un hydrate de celui-ci, puis la neutralisation du sel inorganique d'ilaprazole préparé ou de l'hydrate de celui-ci par un acide dans un solvant organique (solvant unique ou solvant mixte), un procédé de préparation de la forme cristalline B de pureté élevée par l'élimination des impuretés de l'ilaprazole à l'aide d'un solvant organique (solvant unique ou solvant mixte) ; et un procédé de conversion de la forme cristalline A en la forme cristalline B ou de la forme cristalline B en la forme cristalline A.</abstract><oa>free_for_read</oa></addata></record> |
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| title | PROCESSES FOR PREPARING CRYSTALLINE FORMS A AND B OF ILAPRAZOLE AND PROCESS FOR CONVERTING THE CRYSTALLINE FORMS |
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