IMPLANTABLE BONE GRAFT MATERIALS

Compositions and methods are provided for promoting bone growth. An implantable bone graft material is provided comprising a resorbable ceramic and a resorbable polymer, wherein the polymer comprises a covalently attached BMP binding peptide. In addition, an implantable bone graft material is provid...

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Hauptverfasser:	CHEN, YUCHEN, NAIR, SHRIKUMAR, AMBUJAKSHAN, HAMILTON, PAUL, THEODORE, MELICAN, MORA, CAROLYNNE, HODGES, JONATHAN, ALLEN
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Sprache:	eng ; fre
Schlagworte:	BANDAGES, DRESSINGS OR ABSORBENT PADS DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF,TUBULAR STRUCTURES OF THE BODY, E.G. STENTS FILTERS IMPLANTABLE INTO BLOOD VESSELS FIRST-AID KITS FOMENTATION HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES PROSTHESES TREATMENT OR PROTECTION OF EYES OR EARS
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creator	CHEN, YUCHEN NAIR, SHRIKUMAR, AMBUJAKSHAN HAMILTON, PAUL, THEODORE MELICAN, MORA, CAROLYNNE HODGES, JONATHAN, ALLEN
description	Compositions and methods are provided for promoting bone growth. An implantable bone graft material is provided comprising a resorbable ceramic and a resorbable polymer, wherein the polymer comprises a covalently attached BMP binding peptide. In addition, an implantable bone graft material is provided consisting essentially of a resorbable ß-TCP and a resorbable polymer, wherein the ß-TCP has a total porosity of about 50% or greater and wherein the ß-TCP has a particle size ranging from about 100 micron to about 300 micron. The implantable bone graft materials are useful for promoting bone growth in a subject. La présente invention concerne des compositions et des méthodes favorisant la croissance osseuse. L'invention concerne un greffon osseux implantable comprenant une céramique résorbable et un polymère résorbable, le polymère comprenant un peptide de liaison aux protéines morphogénétiques osseuses (BMP) fixé de façon covalente. En outre, l'invention concerne un greffon osseux implantable comprenant essentiellement du ß-TCP résorbable et un polymère résorbable, le ß-TCP ayant une porosité totale d'environ 50 % ou plus et le ß-TCP ayant une dimension des particules allant d'environ 100 micromètres à environ 300 micromètres. Les greffons osseux implantables de l'invention sont utiles pour favoriser la croissance osseuse chez un sujet.
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An implantable bone graft material is provided comprising a resorbable ceramic and a resorbable polymer, wherein the polymer comprises a covalently attached BMP binding peptide. In addition, an implantable bone graft material is provided consisting essentially of a resorbable ß-TCP and a resorbable polymer, wherein the ß-TCP has a total porosity of about 50% or greater and wherein the ß-TCP has a particle size ranging from about 100 micron to about 300 micron. The implantable bone graft materials are useful for promoting bone growth in a subject. La présente invention concerne des compositions et des méthodes favorisant la croissance osseuse. L'invention concerne un greffon osseux implantable comprenant une céramique résorbable et un polymère résorbable, le polymère comprenant un peptide de liaison aux protéines morphogénétiques osseuses (BMP) fixé de façon covalente. En outre, l'invention concerne un greffon osseux implantable comprenant essentiellement du ß-TCP résorbable et un polymère résorbable, le ß-TCP ayant une porosité totale d'environ 50 % ou plus et le ß-TCP ayant une dimension des particules allant d'environ 100 micromètres à environ 300 micromètres. Les greffons osseux implantables de l'invention sont utiles pour favoriser la croissance osseuse chez un sujet.</description><language>eng ; fre</language><subject>BANDAGES, DRESSINGS OR ABSORBENT PADS ; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF,TUBULAR STRUCTURES OF THE BODY, E.G. 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STENTS</topic><topic>FILTERS IMPLANTABLE INTO BLOOD VESSELS</topic><topic>FIRST-AID KITS</topic><topic>FOMENTATION</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES</topic><topic>PROSTHESES</topic><topic>TREATMENT OR PROTECTION OF EYES OR EARS</topic><toplevel>online_resources</toplevel><creatorcontrib>CHEN, YUCHEN</creatorcontrib><creatorcontrib>NAIR, SHRIKUMAR, AMBUJAKSHAN</creatorcontrib><creatorcontrib>HAMILTON, PAUL, THEODORE</creatorcontrib><creatorcontrib>MELICAN, MORA, CAROLYNNE</creatorcontrib><creatorcontrib>HODGES, JONATHAN, ALLEN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>CHEN, YUCHEN</au><au>NAIR, SHRIKUMAR, AMBUJAKSHAN</au><au>HAMILTON, PAUL, THEODORE</au><au>MELICAN, MORA, CAROLYNNE</au><au>HODGES, JONATHAN, ALLEN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>IMPLANTABLE BONE GRAFT MATERIALS</title><date>2011-05-26</date><risdate>2011</risdate><abstract>Compositions and methods are provided for promoting bone growth. An implantable bone graft material is provided comprising a resorbable ceramic and a resorbable polymer, wherein the polymer comprises a covalently attached BMP binding peptide. In addition, an implantable bone graft material is provided consisting essentially of a resorbable ß-TCP and a resorbable polymer, wherein the ß-TCP has a total porosity of about 50% or greater and wherein the ß-TCP has a particle size ranging from about 100 micron to about 300 micron. The implantable bone graft materials are useful for promoting bone growth in a subject. La présente invention concerne des compositions et des méthodes favorisant la croissance osseuse. L'invention concerne un greffon osseux implantable comprenant une céramique résorbable et un polymère résorbable, le polymère comprenant un peptide de liaison aux protéines morphogénétiques osseuses (BMP) fixé de façon covalente. En outre, l'invention concerne un greffon osseux implantable comprenant essentiellement du ß-TCP résorbable et un polymère résorbable, le ß-TCP ayant une porosité totale d'environ 50 % ou plus et le ß-TCP ayant une dimension des particules allant d'environ 100 micromètres à environ 300 micromètres. Les greffons osseux implantables de l'invention sont utiles pour favoriser la croissance osseuse chez un sujet.</abstract><oa>free_for_read</oa></addata></record>
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subjects	BANDAGES, DRESSINGS OR ABSORBENT PADS DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF,TUBULAR STRUCTURES OF THE BODY, E.G. STENTS FILTERS IMPLANTABLE INTO BLOOD VESSELS FIRST-AID KITS FOMENTATION HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES PROSTHESES TREATMENT OR PROTECTION OF EYES OR EARS
title	IMPLANTABLE BONE GRAFT MATERIALS
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