A NOVEL PROCESS TO MANUFACTURE (2R,3S)-2-(2,4-DIFLUOROPHENYL)-3-(5-FLUOROPYRIMIDIN-4-YL)-1-(1H-1,2,4-TRIAZOL-1-YL)BUTAN-2-OL
The present invention relates to a novel industrially viable, cost effective process to manufacture substantially pure form of (2R,3S)-2-(2,4-difluorophenyl)-3-(5- fluoropyrimidin-4-yl)-l-(lH-l,2,4-triazol-l-yl)butan-2-ol (Voriconazole) with a chiral purity level of greater than 99.9 % and impurity...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Format: | Patent |
| Sprache: | eng ; fre |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | DEHURY, SANJAY, KUMAR RAMAKRISHNAN, ARUL KAPKOTI, GOBIND, SINGH |
| description | The present invention relates to a novel industrially viable, cost effective process to manufacture substantially pure form of (2R,3S)-2-(2,4-difluorophenyl)-3-(5- fluoropyrimidin-4-yl)-l-(lH-l,2,4-triazol-l-yl)butan-2-ol (Voriconazole) with a chiral purity level of greater than 99.9 % and impurity level of less than 0.1 %.
La présente invention concerne un nouveau procédé économique et industriellement rentable pour la fabrication d'une forme sensiblement pure de (2R,3S)-2-(2,4-difluorophényl)-3-(5- fluoropyrimidin-4-yl)-l-(lH-l,2,4-triazol-l-yl)butan-2-ol (Voriconazole) dont le niveau de pureté chirale est supérieur à 99,9 % et le taux d'impureté est inférieur à 0,1 %. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_WO2011045807A2</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>WO2011045807A2</sourcerecordid><originalsourceid>FETCH-epo_espacenet_WO2011045807A23</originalsourceid><addsrcrecordid>eNqNjEELgjAcxb10iOo7DLpM8A9uKnVdOnGwNplbYReRWKcowY59-BT8AJ0e_H7vvXXwZUjpC5eoNjrnTYOsRmemXMly6wxHmJooaUKggGmUQiFK6bTRdcVVK0NIAGewoNaIsyiEghRmRQCTCkg0z6wR7KblxCZzcpap6VDLbbB69M_R75bcBPuS27wCP7w7Pw793b_8p7tqGhMSp9kxPjCa_Nf6ARGeOZk</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>A NOVEL PROCESS TO MANUFACTURE (2R,3S)-2-(2,4-DIFLUOROPHENYL)-3-(5-FLUOROPYRIMIDIN-4-YL)-1-(1H-1,2,4-TRIAZOL-1-YL)BUTAN-2-OL</title><source>esp@cenet</source><creator>DEHURY, SANJAY, KUMAR ; RAMAKRISHNAN, ARUL ; KAPKOTI, GOBIND, SINGH</creator><creatorcontrib>DEHURY, SANJAY, KUMAR ; RAMAKRISHNAN, ARUL ; KAPKOTI, GOBIND, SINGH</creatorcontrib><description>The present invention relates to a novel industrially viable, cost effective process to manufacture substantially pure form of (2R,3S)-2-(2,4-difluorophenyl)-3-(5- fluoropyrimidin-4-yl)-l-(lH-l,2,4-triazol-l-yl)butan-2-ol (Voriconazole) with a chiral purity level of greater than 99.9 % and impurity level of less than 0.1 %.
La présente invention concerne un nouveau procédé économique et industriellement rentable pour la fabrication d'une forme sensiblement pure de (2R,3S)-2-(2,4-difluorophényl)-3-(5- fluoropyrimidin-4-yl)-l-(lH-l,2,4-triazol-l-yl)butan-2-ol (Voriconazole) dont le niveau de pureté chirale est supérieur à 99,9 % et le taux d'impureté est inférieur à 0,1 %.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2011</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20110421&DB=EPODOC&CC=WO&NR=2011045807A2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20110421&DB=EPODOC&CC=WO&NR=2011045807A2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>DEHURY, SANJAY, KUMAR</creatorcontrib><creatorcontrib>RAMAKRISHNAN, ARUL</creatorcontrib><creatorcontrib>KAPKOTI, GOBIND, SINGH</creatorcontrib><title>A NOVEL PROCESS TO MANUFACTURE (2R,3S)-2-(2,4-DIFLUOROPHENYL)-3-(5-FLUOROPYRIMIDIN-4-YL)-1-(1H-1,2,4-TRIAZOL-1-YL)BUTAN-2-OL</title><description>The present invention relates to a novel industrially viable, cost effective process to manufacture substantially pure form of (2R,3S)-2-(2,4-difluorophenyl)-3-(5- fluoropyrimidin-4-yl)-l-(lH-l,2,4-triazol-l-yl)butan-2-ol (Voriconazole) with a chiral purity level of greater than 99.9 % and impurity level of less than 0.1 %.
La présente invention concerne un nouveau procédé économique et industriellement rentable pour la fabrication d'une forme sensiblement pure de (2R,3S)-2-(2,4-difluorophényl)-3-(5- fluoropyrimidin-4-yl)-l-(lH-l,2,4-triazol-l-yl)butan-2-ol (Voriconazole) dont le niveau de pureté chirale est supérieur à 99,9 % et le taux d'impureté est inférieur à 0,1 %.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2011</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjEELgjAcxb10iOo7DLpM8A9uKnVdOnGwNplbYReRWKcowY59-BT8AJ0e_H7vvXXwZUjpC5eoNjrnTYOsRmemXMly6wxHmJooaUKggGmUQiFK6bTRdcVVK0NIAGewoNaIsyiEghRmRQCTCkg0z6wR7KblxCZzcpap6VDLbbB69M_R75bcBPuS27wCP7w7Pw793b_8p7tqGhMSp9kxPjCa_Nf6ARGeOZk</recordid><startdate>20110421</startdate><enddate>20110421</enddate><creator>DEHURY, SANJAY, KUMAR</creator><creator>RAMAKRISHNAN, ARUL</creator><creator>KAPKOTI, GOBIND, SINGH</creator><scope>EVB</scope></search><sort><creationdate>20110421</creationdate><title>A NOVEL PROCESS TO MANUFACTURE (2R,3S)-2-(2,4-DIFLUOROPHENYL)-3-(5-FLUOROPYRIMIDIN-4-YL)-1-(1H-1,2,4-TRIAZOL-1-YL)BUTAN-2-OL</title><author>DEHURY, SANJAY, KUMAR ; RAMAKRISHNAN, ARUL ; KAPKOTI, GOBIND, SINGH</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2011045807A23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2011</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>DEHURY, SANJAY, KUMAR</creatorcontrib><creatorcontrib>RAMAKRISHNAN, ARUL</creatorcontrib><creatorcontrib>KAPKOTI, GOBIND, SINGH</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>DEHURY, SANJAY, KUMAR</au><au>RAMAKRISHNAN, ARUL</au><au>KAPKOTI, GOBIND, SINGH</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>A NOVEL PROCESS TO MANUFACTURE (2R,3S)-2-(2,4-DIFLUOROPHENYL)-3-(5-FLUOROPYRIMIDIN-4-YL)-1-(1H-1,2,4-TRIAZOL-1-YL)BUTAN-2-OL</title><date>2011-04-21</date><risdate>2011</risdate><abstract>The present invention relates to a novel industrially viable, cost effective process to manufacture substantially pure form of (2R,3S)-2-(2,4-difluorophenyl)-3-(5- fluoropyrimidin-4-yl)-l-(lH-l,2,4-triazol-l-yl)butan-2-ol (Voriconazole) with a chiral purity level of greater than 99.9 % and impurity level of less than 0.1 %.
La présente invention concerne un nouveau procédé économique et industriellement rentable pour la fabrication d'une forme sensiblement pure de (2R,3S)-2-(2,4-difluorophényl)-3-(5- fluoropyrimidin-4-yl)-l-(lH-l,2,4-triazol-l-yl)butan-2-ol (Voriconazole) dont le niveau de pureté chirale est supérieur à 99,9 % et le taux d'impureté est inférieur à 0,1 %.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng ; fre |
| recordid | cdi_epo_espacenet_WO2011045807A2 |
| source | esp@cenet |
| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY |
| title | A NOVEL PROCESS TO MANUFACTURE (2R,3S)-2-(2,4-DIFLUOROPHENYL)-3-(5-FLUOROPYRIMIDIN-4-YL)-1-(1H-1,2,4-TRIAZOL-1-YL)BUTAN-2-OL |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T13%3A18%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=DEHURY,%20SANJAY,%20KUMAR&rft.date=2011-04-21&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EWO2011045807A2%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |