COMBINATION
The present invention relates to a method of treating cancer in a mammal and to pharmaceutical combinations useful in such treatment. In particular, the method relates to a novel combination comprising the MEK inhibitor: N -{3-[3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo...
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| creator | GILMER, TONA, M GRESHOCK, JOEL, DAVID BACHMAN, KURTIS, EARL GREGER, JAMES, G., JR LIU, LI MORRIS, SHANNON, RENAE LAQUERRE, SYLVIE AUGER, KURT, R |
| description | The present invention relates to a method of treating cancer in a mammal and to pharmaceutical combinations useful in such treatment. In particular, the method relates to a novel combination comprising the MEK inhibitor: N -{3-[3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d/]pyrimidin-1 (2H)-yl]phenyl}acetamide, or a pharmaceutically acceptable salt or solvate thereof, and the PI3 kinase inhibitor: 2,4-difluoro-N-{2-(methyloxy)-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl}benzenesulfonamide, or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising the same, andNN
L'invention concerne un procédé pour traiter un cancer chez un mammifère et des associations pharmaceutiques utiles dans un tel traitement. En particulier, ce procédé concerne une nouvelle combinaison contenant l'inhibiteur de MEK:N-{3-[3-cyclopropyl-5-[(2-fluoro-4-iodophényl)amino]-6,8-diméthyl-2,4,7-trioxo-3,4,6,7-tétrahydropyrido[4,3-c/]pyrimidin-1 (2/-/)-yl]phényl}acétamide, ou un sel ou un solvate pharmaceutiquement acceptable de celui-ci, et l'inhibiteur de la PI3 kinase : 2,4-difluoro-N-{2-(méthyloxy)-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl}benzènesulfonamide, ou un sel pharmaceutiquement acceptable de celui-ci, des compositions pharmaceutiquement contenant celui-ci, et |
| format | Patent |
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L'invention concerne un procédé pour traiter un cancer chez un mammifère et des associations pharmaceutiques utiles dans un tel traitement. En particulier, ce procédé concerne une nouvelle combinaison contenant l'inhibiteur de MEK:N-{3-[3-cyclopropyl-5-[(2-fluoro-4-iodophényl)amino]-6,8-diméthyl-2,4,7-trioxo-3,4,6,7-tétrahydropyrido[4,3-c/]pyrimidin-1 (2/-/)-yl]phényl}acétamide, ou un sel ou un solvate pharmaceutiquement acceptable de celui-ci, et l'inhibiteur de la PI3 kinase : 2,4-difluoro-N-{2-(méthyloxy)-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl}benzènesulfonamide, ou un sel pharmaceutiquement acceptable de celui-ci, des compositions pharmaceutiquement contenant celui-ci, et</description><language>eng ; fre</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2011</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20110915&DB=EPODOC&CC=WO&NR=2011038380A3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20110915&DB=EPODOC&CC=WO&NR=2011038380A3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>GILMER, TONA, M</creatorcontrib><creatorcontrib>GRESHOCK, JOEL, DAVID</creatorcontrib><creatorcontrib>BACHMAN, KURTIS, EARL</creatorcontrib><creatorcontrib>GREGER, JAMES, G., JR</creatorcontrib><creatorcontrib>LIU, LI</creatorcontrib><creatorcontrib>MORRIS, SHANNON, RENAE</creatorcontrib><creatorcontrib>LAQUERRE, SYLVIE</creatorcontrib><creatorcontrib>AUGER, KURT, R</creatorcontrib><title>COMBINATION</title><description>The present invention relates to a method of treating cancer in a mammal and to pharmaceutical combinations useful in such treatment. In particular, the method relates to a novel combination comprising the MEK inhibitor: N -{3-[3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d/]pyrimidin-1 (2H)-yl]phenyl}acetamide, or a pharmaceutically acceptable salt or solvate thereof, and the PI3 kinase inhibitor: 2,4-difluoro-N-{2-(methyloxy)-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl}benzenesulfonamide, or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising the same, andNN
L'invention concerne un procédé pour traiter un cancer chez un mammifère et des associations pharmaceutiques utiles dans un tel traitement. En particulier, ce procédé concerne une nouvelle combinaison contenant l'inhibiteur de MEK:N-{3-[3-cyclopropyl-5-[(2-fluoro-4-iodophényl)amino]-6,8-diméthyl-2,4,7-trioxo-3,4,6,7-tétrahydropyrido[4,3-c/]pyrimidin-1 (2/-/)-yl]phényl}acétamide, ou un sel ou un solvate pharmaceutiquement acceptable de celui-ci, et l'inhibiteur de la PI3 kinase : 2,4-difluoro-N-{2-(méthyloxy)-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl}benzènesulfonamide, ou un sel pharmaceutiquement acceptable de celui-ci, des compositions pharmaceutiquement contenant celui-ci, et</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2011</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZOB29vd18vRzDPH09-NhYE1LzClO5YXS3AzKbq4hzh66qQX58anFBYnJqXmpJfHh_kYGhoYGxhbGFgaOxsbEqQIA6FgdDQ</recordid><startdate>20110915</startdate><enddate>20110915</enddate><creator>GILMER, TONA, M</creator><creator>GRESHOCK, JOEL, DAVID</creator><creator>BACHMAN, KURTIS, EARL</creator><creator>GREGER, JAMES, G., JR</creator><creator>LIU, LI</creator><creator>MORRIS, SHANNON, RENAE</creator><creator>LAQUERRE, SYLVIE</creator><creator>AUGER, KURT, R</creator><scope>EVB</scope></search><sort><creationdate>20110915</creationdate><title>COMBINATION</title><author>GILMER, TONA, M ; GRESHOCK, JOEL, DAVID ; BACHMAN, KURTIS, EARL ; GREGER, JAMES, G., JR ; LIU, LI ; MORRIS, SHANNON, RENAE ; LAQUERRE, SYLVIE ; AUGER, KURT, R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2011038380A33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2011</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>GILMER, TONA, M</creatorcontrib><creatorcontrib>GRESHOCK, JOEL, DAVID</creatorcontrib><creatorcontrib>BACHMAN, KURTIS, EARL</creatorcontrib><creatorcontrib>GREGER, JAMES, G., JR</creatorcontrib><creatorcontrib>LIU, LI</creatorcontrib><creatorcontrib>MORRIS, SHANNON, RENAE</creatorcontrib><creatorcontrib>LAQUERRE, SYLVIE</creatorcontrib><creatorcontrib>AUGER, KURT, R</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>GILMER, TONA, M</au><au>GRESHOCK, JOEL, DAVID</au><au>BACHMAN, KURTIS, EARL</au><au>GREGER, JAMES, G., JR</au><au>LIU, LI</au><au>MORRIS, SHANNON, RENAE</au><au>LAQUERRE, SYLVIE</au><au>AUGER, KURT, R</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>COMBINATION</title><date>2011-09-15</date><risdate>2011</risdate><abstract>The present invention relates to a method of treating cancer in a mammal and to pharmaceutical combinations useful in such treatment. In particular, the method relates to a novel combination comprising the MEK inhibitor: N -{3-[3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d/]pyrimidin-1 (2H)-yl]phenyl}acetamide, or a pharmaceutically acceptable salt or solvate thereof, and the PI3 kinase inhibitor: 2,4-difluoro-N-{2-(methyloxy)-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl}benzenesulfonamide, or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising the same, andNN
L'invention concerne un procédé pour traiter un cancer chez un mammifère et des associations pharmaceutiques utiles dans un tel traitement. En particulier, ce procédé concerne une nouvelle combinaison contenant l'inhibiteur de MEK:N-{3-[3-cyclopropyl-5-[(2-fluoro-4-iodophényl)amino]-6,8-diméthyl-2,4,7-trioxo-3,4,6,7-tétrahydropyrido[4,3-c/]pyrimidin-1 (2/-/)-yl]phényl}acétamide, ou un sel ou un solvate pharmaceutiquement acceptable de celui-ci, et l'inhibiteur de la PI3 kinase : 2,4-difluoro-N-{2-(méthyloxy)-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl}benzènesulfonamide, ou un sel pharmaceutiquement acceptable de celui-ci, des compositions pharmaceutiquement contenant celui-ci, et</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | COMBINATION |
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