PROCESS FOR PREPARATION OF OLOPATADINE HYDROCHLORIDE

PROCESS FOR PREPARATION OF OLOPATADINE HYDROCHLORIDE

Disclosed here is a process for preparation of compound 11 - (Z) - [3 - (Dimethylamino) propylidene] - 6, 11 - dihydrodibenz [b, e] oxepin -2 - yl - acetic acid (Olopatadine) and its pharmaceutically acceptable salt comprising reacting compound of Formula (XII) where R1 & R2 independently repres...

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Hauptverfasser: DESHMUKH, SANDIP, KACHARU, KHABALE, SOMNATH, PANANDIKAR, ADITI, MILIND, NAIR, RANJEET, RAMESAN, P., V
Format: Patent
Sprache:eng ; fre
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CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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creator DESHMUKH, SANDIP, KACHARU
KHABALE, SOMNATH
PANANDIKAR, ADITI, MILIND
NAIR, RANJEET
RAMESAN, P., V
description Disclosed here is a process for preparation of compound 11 - (Z) - [3 - (Dimethylamino) propylidene] - 6, 11 - dihydrodibenz [b, e] oxepin -2 - yl - acetic acid (Olopatadine) and its pharmaceutically acceptable salt comprising reacting compound of Formula (XII) where R1 & R2 independently represent H, or C1 - C4 alkyl group; with 3-dimethylaminopropyl magnesium halide of Formula (XIII) where X is Chlorine, bromine or iodine. L'invention concerne un procédé de préparation d'un composé d'acide 11-(Z)-[3-diméthylamino)propylidène]-6,11-dihydrodibenz[b,e]oxépin-2-yl-acétique (olopatadine) et de ses sels pharmaceutiquement acceptables. Le procédé consiste à mettre en réaction un composé de formule (XII) dans laquelle R1 et R2 représentent indépendamment H ou groupe alkyle C1-C4 avec un halogénure de 3-diméthylaminopropyl magnésium de formule (XIII) dans laquelle X est chlorure, brome ou iode.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title PROCESS FOR PREPARATION OF OLOPATADINE HYDROCHLORIDE
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