A ONE POT PROCESS FOR PREPARING 2-BUTYL-3-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1,3-DIAZASPIRO [4, 4] NON-1-EN-4-ONE (IRBESARTAN)
A one pot process for the synthesis of Irbesartan comprising reacting 2-n-Butyl-1, 3-Diazaspiro [4, 4] Non -1-en-4-one (Formula III) and Bromomethyl Cyanobiphenyl (Formula IV) in the presence of base and water with the optional use of PTC to give formula II from which Irbesartan is obtained by react...
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| creator | SRIVASTAVA, BIMAL, KUMAR KOLHE, PRAKASH, YASHWANT PATEL, NITIN, JERAMBHAI JOSHI, RAJESH, DILIP GAJJAR, SANKET, SURESHBHAI |
| description | A one pot process for the synthesis of Irbesartan comprising reacting 2-n-Butyl-1, 3-Diazaspiro [4, 4] Non -1-en-4-one (Formula III) and Bromomethyl Cyanobiphenyl (Formula IV) in the presence of base and water with the optional use of PTC to give formula II from which Irbesartan is obtained by reacting with sodium azide and triethylamine hydrochloride in the presence of a non polar solvent.
L'invention porte sur un procédé monotope de synthèse de l'Irbesartan qui comporte la réaction de la 2-n-butyl-1,3-diazaspiro[4,4]non-1-én-4-one (Formule III) et du bromométhyl cyanobiphényle (Formule IV) en présence d'une base et d'eau avec l'utilisation facultative de PTC pour donner la formule II à partir de laquelle l'Irbesartan est obtenu par réaction avec de l'azide de sodium et du chlorhydrate de triéthylamine en présence d'un solvant non polaire. |
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L'invention porte sur un procédé monotope de synthèse de l'Irbesartan qui comporte la réaction de la 2-n-butyl-1,3-diazaspiro[4,4]non-1-én-4-one (Formule III) et du bromométhyl cyanobiphényle (Formule IV) en présence d'une base et d'eau avec l'utilisation facultative de PTC pour donner la formule II à partir de laquelle l'Irbesartan est obtenu par réaction avec de l'azide de sodium et du chlorhydrate de triéthylamine en présence d'un solvant non polaire.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2010</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20101014&DB=EPODOC&CC=WO&NR=2010116380A2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25562,76317</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20101014&DB=EPODOC&CC=WO&NR=2010116380A2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SRIVASTAVA, BIMAL, KUMAR</creatorcontrib><creatorcontrib>KOLHE, PRAKASH, YASHWANT</creatorcontrib><creatorcontrib>PATEL, NITIN, JERAMBHAI</creatorcontrib><creatorcontrib>JOSHI, RAJESH, DILIP</creatorcontrib><creatorcontrib>GAJJAR, SANKET, SURESHBHAI</creatorcontrib><title>A ONE POT PROCESS FOR PREPARING 2-BUTYL-3-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1,3-DIAZASPIRO [4, 4] NON-1-EN-4-ONE (IRBESARTAN)</title><description>A one pot process for the synthesis of Irbesartan comprising reacting 2-n-Butyl-1, 3-Diazaspiro [4, 4] Non -1-en-4-one (Formula III) and Bromomethyl Cyanobiphenyl (Formula IV) in the presence of base and water with the optional use of PTC to give formula II from which Irbesartan is obtained by reacting with sodium azide and triethylamine hydrochloride in the presence of a non polar solvent.
L'invention porte sur un procédé monotope de synthèse de l'Irbesartan qui comporte la réaction de la 2-n-butyl-1,3-diazaspiro[4,4]non-1-én-4-one (Formule III) et du bromométhyl cyanobiphényle (Formule IV) en présence d'une base et d'eau avec l'utilisation facultative de PTC pour donner la formule II à partir de laquelle l'Irbesartan est obtenu par réaction avec de l'azide de sodium et du chlorhydrate de triéthylamine en présence d'un solvant non polaire.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2010</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjUEKwjAURLtxIeodAi6q0A9NWsVtql8TqElII1JDKUXiSlTQe3hlK3gAVzPzeDDD6M2JVkiMdsRYvcaqIltt-46GW6l2hEFxcHUJGXjPYphRAQ6d5SddwgLqcu5pQmMopBGo6rKBvIfNHp34DppksJH8xCsjrSY-T0jeEKUVUEDVu9_zmbQFVtw6rubjaHDprs8w-eUomm7RrQWEx70Nz0d3Drfwao-apTSldJmtUs6y_6wP7zE_Rg</recordid><startdate>20101014</startdate><enddate>20101014</enddate><creator>SRIVASTAVA, BIMAL, KUMAR</creator><creator>KOLHE, PRAKASH, YASHWANT</creator><creator>PATEL, NITIN, JERAMBHAI</creator><creator>JOSHI, RAJESH, DILIP</creator><creator>GAJJAR, SANKET, SURESHBHAI</creator><scope>EVB</scope></search><sort><creationdate>20101014</creationdate><title>A ONE POT PROCESS FOR PREPARING 2-BUTYL-3-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1,3-DIAZASPIRO [4, 4] NON-1-EN-4-ONE (IRBESARTAN)</title><author>SRIVASTAVA, BIMAL, KUMAR ; KOLHE, PRAKASH, YASHWANT ; PATEL, NITIN, JERAMBHAI ; JOSHI, RAJESH, DILIP ; GAJJAR, SANKET, SURESHBHAI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2010116380A23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2010</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>SRIVASTAVA, BIMAL, KUMAR</creatorcontrib><creatorcontrib>KOLHE, PRAKASH, YASHWANT</creatorcontrib><creatorcontrib>PATEL, NITIN, JERAMBHAI</creatorcontrib><creatorcontrib>JOSHI, RAJESH, DILIP</creatorcontrib><creatorcontrib>GAJJAR, SANKET, SURESHBHAI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SRIVASTAVA, BIMAL, KUMAR</au><au>KOLHE, PRAKASH, YASHWANT</au><au>PATEL, NITIN, JERAMBHAI</au><au>JOSHI, RAJESH, DILIP</au><au>GAJJAR, SANKET, SURESHBHAI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>A ONE POT PROCESS FOR PREPARING 2-BUTYL-3-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1,3-DIAZASPIRO [4, 4] NON-1-EN-4-ONE (IRBESARTAN)</title><date>2010-10-14</date><risdate>2010</risdate><abstract>A one pot process for the synthesis of Irbesartan comprising reacting 2-n-Butyl-1, 3-Diazaspiro [4, 4] Non -1-en-4-one (Formula III) and Bromomethyl Cyanobiphenyl (Formula IV) in the presence of base and water with the optional use of PTC to give formula II from which Irbesartan is obtained by reacting with sodium azide and triethylamine hydrochloride in the presence of a non polar solvent.
L'invention porte sur un procédé monotope de synthèse de l'Irbesartan qui comporte la réaction de la 2-n-butyl-1,3-diazaspiro[4,4]non-1-én-4-one (Formule III) et du bromométhyl cyanobiphényle (Formule IV) en présence d'une base et d'eau avec l'utilisation facultative de PTC pour donner la formule II à partir de laquelle l'Irbesartan est obtenu par réaction avec de l'azide de sodium et du chlorhydrate de triéthylamine en présence d'un solvant non polaire.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | A ONE POT PROCESS FOR PREPARING 2-BUTYL-3-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1,3-DIAZASPIRO [4, 4] NON-1-EN-4-ONE (IRBESARTAN) |
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