THIAZOLOPYRIMIDINE MODULATORS AS IMMUNOSUPPRESSIVE AGENTS
The present invention relates to compound of formula I, II, III, or IV, and/or a pharmaceutical acceptable addition salt thereof and/or a stereoisomer thereof and/or a solvate thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R11, and R12 are as defined in the claim 1. The present invention also...
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| creator | LOUAT, THIERRY ANDRE MICHEL HERDEWIJN, PIET WAER, MARK JOZEF ALBERT GAO, LING-JIE HERMAN, JEAN FERDINAND JANG, MI-YEON VANDERHOYDONCK, BART DE JONGHE, STEVEN LIN, YUAN |
| description | The present invention relates to compound of formula I, II, III, or IV, and/or a pharmaceutical acceptable addition salt thereof and/or a stereoisomer thereof and/or a solvate thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R11, and R12 are as defined in the claim 1. The present invention also relates to a method for their preparation, as well as to pharmaceutical compositions thereof. The present invention further relates to the use of said compounds as biologically active ingredients, more specifically as medicaments for the treatment of disorders and pathologic conditions such as, but not limited to, immune and auto-immune disorders, organ and cells transplant rejections.
La présente invention porte sur un composé de formule I, II, III, ou IV, et/ou un sel d'addition pharmaceutique acceptable de celui-ci et/ou un stéréoisomère de celui-ci et/ou un solvate de celui-ci, dans lesquelles formules R1, R2, R3, R4, R5, R6, R7, R8, R9, R11 et R12 sont tels que définis dans la revendication 1. La présente invention porte également sur leur procédé de préparation, ainsi que sur des compositions pharmaceutiques contenant lesdits composés. La présente invention porte en outre sur l'utilisation desdits composés comme principes biologiquement actifs, plus spécifiquement comme médicaments pour le traitement de troubles et d'affections pathologiques tels que, mais sans que la liste soit exhaustive, des troubles immuns et auto-immuns, des rejets de greffe d'organe et de cellules. |
| format | Patent |
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La présente invention porte sur un composé de formule I, II, III, ou IV, et/ou un sel d'addition pharmaceutique acceptable de celui-ci et/ou un stéréoisomère de celui-ci et/ou un solvate de celui-ci, dans lesquelles formules R1, R2, R3, R4, R5, R6, R7, R8, R9, R11 et R12 sont tels que définis dans la revendication 1. La présente invention porte également sur leur procédé de préparation, ainsi que sur des compositions pharmaceutiques contenant lesdits composés. La présente invention porte en outre sur l'utilisation desdits composés comme principes biologiquement actifs, plus spécifiquement comme médicaments pour le traitement de troubles et d'affections pathologiques tels que, mais sans que la liste soit exhaustive, des troubles immuns et auto-immuns, des rejets de greffe d'organe et de cellules.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2010</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20101223&DB=EPODOC&CC=WO&NR=2010103130A3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20101223&DB=EPODOC&CC=WO&NR=2010103130A3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LOUAT, THIERRY ANDRE MICHEL</creatorcontrib><creatorcontrib>HERDEWIJN, PIET</creatorcontrib><creatorcontrib>WAER, MARK JOZEF ALBERT</creatorcontrib><creatorcontrib>GAO, LING-JIE</creatorcontrib><creatorcontrib>HERMAN, JEAN FERDINAND</creatorcontrib><creatorcontrib>JANG, MI-YEON</creatorcontrib><creatorcontrib>VANDERHOYDONCK, BART</creatorcontrib><creatorcontrib>DE JONGHE, STEVEN</creatorcontrib><creatorcontrib>LIN, YUAN</creatorcontrib><title>THIAZOLOPYRIMIDINE MODULATORS AS IMMUNOSUPPRESSIVE AGENTS</title><description>The present invention relates to compound of formula I, II, III, or IV, and/or a pharmaceutical acceptable addition salt thereof and/or a stereoisomer thereof and/or a solvate thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R11, and R12 are as defined in the claim 1. The present invention also relates to a method for their preparation, as well as to pharmaceutical compositions thereof. The present invention further relates to the use of said compounds as biologically active ingredients, more specifically as medicaments for the treatment of disorders and pathologic conditions such as, but not limited to, immune and auto-immune disorders, organ and cells transplant rejections.
La présente invention porte sur un composé de formule I, II, III, ou IV, et/ou un sel d'addition pharmaceutique acceptable de celui-ci et/ou un stéréoisomère de celui-ci et/ou un solvate de celui-ci, dans lesquelles formules R1, R2, R3, R4, R5, R6, R7, R8, R9, R11 et R12 sont tels que définis dans la revendication 1. La présente invention porte également sur leur procédé de préparation, ainsi que sur des compositions pharmaceutiques contenant lesdits composés. La présente invention porte en outre sur l'utilisation desdits composés comme principes biologiquement actifs, plus spécifiquement comme médicaments pour le traitement de troubles et d'affections pathologiques tels que, mais sans que la liste soit exhaustive, des troubles immuns et auto-immuns, des rejets de greffe d'organe et de cellules.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2010</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLAM8fB0jPL38Q-IDPL09XTx9HNV8PV3CfVxDPEPClZwDFbw9PUN9fMPDg0ICHINDvYMc1VwdHf1CwnmYWBNS8wpTuWF0twMym6uIc4euqkF-fGpxQWJyal5qSXx4f5GBoZAaGxobOBobEycKgCbEips</recordid><startdate>20101223</startdate><enddate>20101223</enddate><creator>LOUAT, THIERRY ANDRE MICHEL</creator><creator>HERDEWIJN, PIET</creator><creator>WAER, MARK JOZEF ALBERT</creator><creator>GAO, LING-JIE</creator><creator>HERMAN, JEAN FERDINAND</creator><creator>JANG, MI-YEON</creator><creator>VANDERHOYDONCK, BART</creator><creator>DE JONGHE, STEVEN</creator><creator>LIN, YUAN</creator><scope>EVB</scope></search><sort><creationdate>20101223</creationdate><title>THIAZOLOPYRIMIDINE MODULATORS AS IMMUNOSUPPRESSIVE AGENTS</title><author>LOUAT, THIERRY ANDRE MICHEL ; HERDEWIJN, PIET ; WAER, MARK JOZEF ALBERT ; GAO, LING-JIE ; HERMAN, JEAN FERDINAND ; JANG, MI-YEON ; VANDERHOYDONCK, BART ; DE JONGHE, STEVEN ; LIN, YUAN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2010103130A33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2010</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>LOUAT, THIERRY ANDRE MICHEL</creatorcontrib><creatorcontrib>HERDEWIJN, PIET</creatorcontrib><creatorcontrib>WAER, MARK JOZEF ALBERT</creatorcontrib><creatorcontrib>GAO, LING-JIE</creatorcontrib><creatorcontrib>HERMAN, JEAN FERDINAND</creatorcontrib><creatorcontrib>JANG, MI-YEON</creatorcontrib><creatorcontrib>VANDERHOYDONCK, BART</creatorcontrib><creatorcontrib>DE JONGHE, STEVEN</creatorcontrib><creatorcontrib>LIN, YUAN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LOUAT, THIERRY ANDRE MICHEL</au><au>HERDEWIJN, PIET</au><au>WAER, MARK JOZEF ALBERT</au><au>GAO, LING-JIE</au><au>HERMAN, JEAN FERDINAND</au><au>JANG, MI-YEON</au><au>VANDERHOYDONCK, BART</au><au>DE JONGHE, STEVEN</au><au>LIN, YUAN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>THIAZOLOPYRIMIDINE MODULATORS AS IMMUNOSUPPRESSIVE AGENTS</title><date>2010-12-23</date><risdate>2010</risdate><abstract>The present invention relates to compound of formula I, II, III, or IV, and/or a pharmaceutical acceptable addition salt thereof and/or a stereoisomer thereof and/or a solvate thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R11, and R12 are as defined in the claim 1. The present invention also relates to a method for their preparation, as well as to pharmaceutical compositions thereof. The present invention further relates to the use of said compounds as biologically active ingredients, more specifically as medicaments for the treatment of disorders and pathologic conditions such as, but not limited to, immune and auto-immune disorders, organ and cells transplant rejections.
La présente invention porte sur un composé de formule I, II, III, ou IV, et/ou un sel d'addition pharmaceutique acceptable de celui-ci et/ou un stéréoisomère de celui-ci et/ou un solvate de celui-ci, dans lesquelles formules R1, R2, R3, R4, R5, R6, R7, R8, R9, R11 et R12 sont tels que définis dans la revendication 1. La présente invention porte également sur leur procédé de préparation, ainsi que sur des compositions pharmaceutiques contenant lesdits composés. La présente invention porte en outre sur l'utilisation desdits composés comme principes biologiquement actifs, plus spécifiquement comme médicaments pour le traitement de troubles et d'affections pathologiques tels que, mais sans que la liste soit exhaustive, des troubles immuns et auto-immuns, des rejets de greffe d'organe et de cellules.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | THIAZOLOPYRIMIDINE MODULATORS AS IMMUNOSUPPRESSIVE AGENTS |
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