METHODS AND COMPOSITIONS FOR USE OF A COCCIDIOSIS VACCINE

The present invention relates to a coccidiosis vaccine to protect poultry against Eimeria infection, comprising a recombinant avian adenovirus vector comprising in frame a (heterologous) promoter linked to a hydrophobic signal sequence for membrane anchoring, or linked to an hydrophobic secretion si...

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1. Verfasser: SHEPPARD, MICHAEL G
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description The present invention relates to a coccidiosis vaccine to protect poultry against Eimeria infection, comprising a recombinant avian adenovirus vector comprising in frame a (heterologous) promoter linked to a hydrophobic signal sequence for membrane anchoring, or linked to an hydrophobic secretion signal and a cleavage site to allow secretion; a multiple cloning site for in frame insertion of an Eimeria antigen ORF such as derived from the r56, 82 kDa, and/or TFP250 antigens; a polyadenylation signal; and an avian adenovirus genome. La présente invention concerne un vaccin contre la coccidiose pour protéger les volailles contre une infection par Eimeria, comprenant un vecteur d'adénovirus aviaire recombinant comprenant en phase un promoteur (hétérologue) lié à une séquence signal hydrophobe pour l'ancrage membranaire, ou lié à un signal de sécrétion hydrophobe et un site de clivage pour permettre la sécrétion; un site de clonage multiple pour l'insertion dans le cadre d'un ORF d'antigène d'Eimeria tel que celui dérivé des antigènes r56, 82 kDa, et/ou TFP250; un signal de polyadénylation; et un génome d'adénovirus aviaire.
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subjects BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
VINEGAR
WINE
title METHODS AND COMPOSITIONS FOR USE OF A COCCIDIOSIS VACCINE
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