SUBSTITUTED 2-(5-HYDROXY-2-METHYL-1N-INDOLE-3-IL) ACETIC ACIDS AND ETHERS THEREOF AND THE USE OF SAME TO TREAT VIRAL DISEASES
The invention relates to new substituted 2-(5-hydroxy-2-methyl-1n-indole-3-il) acetic acids, new antiviral active agents, pharmaceutical compositions, antiviral medicinal agents and a method for preventing and treating viral diseases, in particular diseases caused by the influenza virus and the infe...
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| creator | MITKIN, OLEG DMITRIEVICH YAMANUSHKIN, PAVEL MIKHAILOVICH BICHKO, VADIM VASILIEVICH IVACHTCHENKO, ALEXANDRE VASILIEVICH SAVCHUK, NIKOLAY FILIPPOVICH IVASHCHENKO, ANDREY ALEXANDROVICH VVEDENSKY, VLADIMIR YURIEVICH |
| description | The invention relates to new substituted 2-(5-hydroxy-2-methyl-1n-indole-3-il) acetic acids, new antiviral active agents, pharmaceutical compositions, antiviral medicinal agents and a method for preventing and treating viral diseases, in particular diseases caused by the influenza virus and the infectious hepatitis C virus (HCV). New substituted 2-(5-hydroxy-2-methyl-1n-indole-3-il) acetic acids and ethers thereof of the general formula 1 as well as pharmaceutically acceptable salts and/or hydrates thereof are proposed, where R1 is an amino group substituent selected from a hydrogen atom, an optionally substituted C1-C5 alkyl, acyl or sulphonyl; R2 and R4 independently from each other represent an alkyl substituent selected from a hydrogen atom, a halogen atom, an optionally substituted C1-C3 alkyl, optionally substituted hydroxyl, an optionally substituted amino group, optionally substituted amino methyl and a substituted mercapto group; R3 is hydrogen and optionally substituted lower alkyl C1-C5; R5 is a cyclic system substituent selected from a hydrogen atom, fluorine atom, trifluormethyl, carboxyl, alkyloxycarbonyl, possibly substituted aryl, heterocyclyl, optionally substituted amino methyl and a cyano group; R6 represents a hydroxyl substituent selected form a hydrogen atom, optionally substituted lower alkyl C1-C5 and acyl.
L'invention concerne de nouveaux acides 2-(5-hydroxy-2-méthyl-1N-indole-3-Il) acétiques substitués, de nouveaux agents actifs antiviraux, des compositions pharmaceutiques, des médicaments antiviraux, et un procédé pour prévenir et traiter des maladies virales, en particulier des maladies causées par des virus influenza et infectieuses de l'hépatite C (VHC). Les nouveaux acides 2-(5-hydroxy-2-méthyl-1N-indole-3-Il) acétiques substitués et leurs éthers possèdent la formule générale 1, ainsi que leurs sels pharmaceutiquement acceptables et/ou leurs hydrates; dans cette formule, R1 est un substituant de groupe aminé choisi parmi un atome d'hydrogène, un alkyle C1-C5 éventuellement substitué, un acyle ou un sulfonyle; R2 et R4 se présentent indépendamment l'un de l'autre un substituant alkyle choisi parmi un atome d'hydrogène, un atome d'halogène, un alkyle C1-C3 éventuellement substitué, un hydroxyle éventuellement substitué, un groupe aminé éventuellement substitué, un aminométhyle éventuellement substitué ou un groupe mercapto substitué; R3 est l'hydrogène, alkyle inférieur C1-C5 éventuellement substitué; R5 est un substituant de s |
| format | Patent |
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L'invention concerne de nouveaux acides 2-(5-hydroxy-2-méthyl-1N-indole-3-Il) acétiques substitués, de nouveaux agents actifs antiviraux, des compositions pharmaceutiques, des médicaments antiviraux, et un procédé pour prévenir et traiter des maladies virales, en particulier des maladies causées par des virus influenza et infectieuses de l'hépatite C (VHC). Les nouveaux acides 2-(5-hydroxy-2-méthyl-1N-indole-3-Il) acétiques substitués et leurs éthers possèdent la formule générale 1, ainsi que leurs sels pharmaceutiquement acceptables et/ou leurs hydrates; dans cette formule, R1 est un substituant de groupe aminé choisi parmi un atome d'hydrogène, un alkyle C1-C5 éventuellement substitué, un acyle ou un sulfonyle; R2 et R4 se présentent indépendamment l'un de l'autre un substituant alkyle choisi parmi un atome d'hydrogène, un atome d'halogène, un alkyle C1-C3 éventuellement substitué, un hydroxyle éventuellement substitué, un groupe aminé éventuellement substitué, un aminométhyle éventuellement substitué ou un groupe mercapto substitué; R3 est l'hydrogène, alkyle inférieur C1-C5 éventuellement substitué; R5 est un substituant de système cyclique choisi parmi un atome d'hydrogène, un atome de fluor, un trifluorméthyle, un carboxyle, un alkyloxycarbonyle, un aryle éventuellement substitué, un hétérocyclyle, un aminométhyle éventuellement substitué et un groupe cyano; et R6 se présente comme un substituant d'hydroxyle sélectionné parmi un atome d'hydrogène, un alkyle inférieur C1-C5 éventuellement substitué et un acyle.</description><language>eng ; fre ; rus</language><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2010</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20100603&DB=EPODOC&CC=WO&NR=2010062221A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20100603&DB=EPODOC&CC=WO&NR=2010062221A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MITKIN, OLEG DMITRIEVICH</creatorcontrib><creatorcontrib>YAMANUSHKIN, PAVEL MIKHAILOVICH</creatorcontrib><creatorcontrib>BICHKO, VADIM VASILIEVICH</creatorcontrib><creatorcontrib>IVACHTCHENKO, ALEXANDRE VASILIEVICH</creatorcontrib><creatorcontrib>SAVCHUK, NIKOLAY FILIPPOVICH</creatorcontrib><creatorcontrib>IVASHCHENKO, ANDREY ALEXANDROVICH</creatorcontrib><creatorcontrib>VVEDENSKY, VLADIMIR YURIEVICH</creatorcontrib><title>SUBSTITUTED 2-(5-HYDROXY-2-METHYL-1N-INDOLE-3-IL) ACETIC ACIDS AND ETHERS THEREOF AND THE USE OF SAME TO TREAT VIRAL DISEASES</title><description>The invention relates to new substituted 2-(5-hydroxy-2-methyl-1n-indole-3-il) acetic acids, new antiviral active agents, pharmaceutical compositions, antiviral medicinal agents and a method for preventing and treating viral diseases, in particular diseases caused by the influenza virus and the infectious hepatitis C virus (HCV). New substituted 2-(5-hydroxy-2-methyl-1n-indole-3-il) acetic acids and ethers thereof of the general formula 1 as well as pharmaceutically acceptable salts and/or hydrates thereof are proposed, where R1 is an amino group substituent selected from a hydrogen atom, an optionally substituted C1-C5 alkyl, acyl or sulphonyl; R2 and R4 independently from each other represent an alkyl substituent selected from a hydrogen atom, a halogen atom, an optionally substituted C1-C3 alkyl, optionally substituted hydroxyl, an optionally substituted amino group, optionally substituted amino methyl and a substituted mercapto group; R3 is hydrogen and optionally substituted lower alkyl C1-C5; R5 is a cyclic system substituent selected from a hydrogen atom, fluorine atom, trifluormethyl, carboxyl, alkyloxycarbonyl, possibly substituted aryl, heterocyclyl, optionally substituted amino methyl and a cyano group; R6 represents a hydroxyl substituent selected form a hydrogen atom, optionally substituted lower alkyl C1-C5 and acyl.
L'invention concerne de nouveaux acides 2-(5-hydroxy-2-méthyl-1N-indole-3-Il) acétiques substitués, de nouveaux agents actifs antiviraux, des compositions pharmaceutiques, des médicaments antiviraux, et un procédé pour prévenir et traiter des maladies virales, en particulier des maladies causées par des virus influenza et infectieuses de l'hépatite C (VHC). Les nouveaux acides 2-(5-hydroxy-2-méthyl-1N-indole-3-Il) acétiques substitués et leurs éthers possèdent la formule générale 1, ainsi que leurs sels pharmaceutiquement acceptables et/ou leurs hydrates; dans cette formule, R1 est un substituant de groupe aminé choisi parmi un atome d'hydrogène, un alkyle C1-C5 éventuellement substitué, un acyle ou un sulfonyle; R2 et R4 se présentent indépendamment l'un de l'autre un substituant alkyle choisi parmi un atome d'hydrogène, un atome d'halogène, un alkyle C1-C3 éventuellement substitué, un hydroxyle éventuellement substitué, un groupe aminé éventuellement substitué, un aminométhyle éventuellement substitué ou un groupe mercapto substitué; R3 est l'hydrogène, alkyle inférieur C1-C5 éventuellement substitué; R5 est un substituant de système cyclique choisi parmi un atome d'hydrogène, un atome de fluor, un trifluorméthyle, un carboxyle, un alkyloxycarbonyle, un aryle éventuellement substitué, un hétérocyclyle, un aminométhyle éventuellement substitué et un groupe cyano; et R6 se présente comme un substituant d'hydroxyle sélectionné parmi un atome d'hydrogène, un alkyle inférieur C1-C5 éventuellement substitué et un acyle.</description><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2010</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNirEKwkAQRNNYiPoPCzZaLCQXtD9zG3JwyUF2o6YKQc5KNBBb_90ofoDNvJnhzaMXNwcWK42QAYWbHRatqf25RYUlSdE6TCq0lfGOMEXrtqAzEptNsIZBVwYmjWqGT5LPv9fUoWGCabIuCcSD1KQFjrbWDoxl0ky8jGbX_jaG1Y-LaJ2TZAWG4dGFcegv4R6e3cmrOInjvVIq0Un6n_UG3Rk62A</recordid><startdate>20100603</startdate><enddate>20100603</enddate><creator>MITKIN, OLEG DMITRIEVICH</creator><creator>YAMANUSHKIN, PAVEL MIKHAILOVICH</creator><creator>BICHKO, VADIM VASILIEVICH</creator><creator>IVACHTCHENKO, ALEXANDRE VASILIEVICH</creator><creator>SAVCHUK, NIKOLAY FILIPPOVICH</creator><creator>IVASHCHENKO, ANDREY ALEXANDROVICH</creator><creator>VVEDENSKY, VLADIMIR YURIEVICH</creator><scope>EVB</scope></search><sort><creationdate>20100603</creationdate><title>SUBSTITUTED 2-(5-HYDROXY-2-METHYL-1N-INDOLE-3-IL) ACETIC ACIDS AND ETHERS THEREOF AND THE USE OF SAME TO TREAT VIRAL DISEASES</title><author>MITKIN, OLEG DMITRIEVICH ; YAMANUSHKIN, PAVEL MIKHAILOVICH ; BICHKO, VADIM VASILIEVICH ; IVACHTCHENKO, ALEXANDRE VASILIEVICH ; SAVCHUK, NIKOLAY FILIPPOVICH ; IVASHCHENKO, ANDREY ALEXANDROVICH ; VVEDENSKY, VLADIMIR YURIEVICH</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2010062221A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; rus</language><creationdate>2010</creationdate><topic>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>MITKIN, OLEG DMITRIEVICH</creatorcontrib><creatorcontrib>YAMANUSHKIN, PAVEL MIKHAILOVICH</creatorcontrib><creatorcontrib>BICHKO, VADIM VASILIEVICH</creatorcontrib><creatorcontrib>IVACHTCHENKO, ALEXANDRE VASILIEVICH</creatorcontrib><creatorcontrib>SAVCHUK, NIKOLAY FILIPPOVICH</creatorcontrib><creatorcontrib>IVASHCHENKO, ANDREY ALEXANDROVICH</creatorcontrib><creatorcontrib>VVEDENSKY, VLADIMIR YURIEVICH</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>MITKIN, OLEG DMITRIEVICH</au><au>YAMANUSHKIN, PAVEL MIKHAILOVICH</au><au>BICHKO, VADIM VASILIEVICH</au><au>IVACHTCHENKO, ALEXANDRE VASILIEVICH</au><au>SAVCHUK, NIKOLAY FILIPPOVICH</au><au>IVASHCHENKO, ANDREY ALEXANDROVICH</au><au>VVEDENSKY, VLADIMIR YURIEVICH</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>SUBSTITUTED 2-(5-HYDROXY-2-METHYL-1N-INDOLE-3-IL) ACETIC ACIDS AND ETHERS THEREOF AND THE USE OF SAME TO TREAT VIRAL DISEASES</title><date>2010-06-03</date><risdate>2010</risdate><abstract>The invention relates to new substituted 2-(5-hydroxy-2-methyl-1n-indole-3-il) acetic acids, new antiviral active agents, pharmaceutical compositions, antiviral medicinal agents and a method for preventing and treating viral diseases, in particular diseases caused by the influenza virus and the infectious hepatitis C virus (HCV). New substituted 2-(5-hydroxy-2-methyl-1n-indole-3-il) acetic acids and ethers thereof of the general formula 1 as well as pharmaceutically acceptable salts and/or hydrates thereof are proposed, where R1 is an amino group substituent selected from a hydrogen atom, an optionally substituted C1-C5 alkyl, acyl or sulphonyl; R2 and R4 independently from each other represent an alkyl substituent selected from a hydrogen atom, a halogen atom, an optionally substituted C1-C3 alkyl, optionally substituted hydroxyl, an optionally substituted amino group, optionally substituted amino methyl and a substituted mercapto group; R3 is hydrogen and optionally substituted lower alkyl C1-C5; R5 is a cyclic system substituent selected from a hydrogen atom, fluorine atom, trifluormethyl, carboxyl, alkyloxycarbonyl, possibly substituted aryl, heterocyclyl, optionally substituted amino methyl and a cyano group; R6 represents a hydroxyl substituent selected form a hydrogen atom, optionally substituted lower alkyl C1-C5 and acyl.
L'invention concerne de nouveaux acides 2-(5-hydroxy-2-méthyl-1N-indole-3-Il) acétiques substitués, de nouveaux agents actifs antiviraux, des compositions pharmaceutiques, des médicaments antiviraux, et un procédé pour prévenir et traiter des maladies virales, en particulier des maladies causées par des virus influenza et infectieuses de l'hépatite C (VHC). Les nouveaux acides 2-(5-hydroxy-2-méthyl-1N-indole-3-Il) acétiques substitués et leurs éthers possèdent la formule générale 1, ainsi que leurs sels pharmaceutiquement acceptables et/ou leurs hydrates; dans cette formule, R1 est un substituant de groupe aminé choisi parmi un atome d'hydrogène, un alkyle C1-C5 éventuellement substitué, un acyle ou un sulfonyle; R2 et R4 se présentent indépendamment l'un de l'autre un substituant alkyle choisi parmi un atome d'hydrogène, un atome d'halogène, un alkyle C1-C3 éventuellement substitué, un hydroxyle éventuellement substitué, un groupe aminé éventuellement substitué, un aminométhyle éventuellement substitué ou un groupe mercapto substitué; R3 est l'hydrogène, alkyle inférieur C1-C5 éventuellement substitué; R5 est un substituant de système cyclique choisi parmi un atome d'hydrogène, un atome de fluor, un trifluorméthyle, un carboxyle, un alkyloxycarbonyle, un aryle éventuellement substitué, un hétérocyclyle, un aminométhyle éventuellement substitué et un groupe cyano; et R6 se présente comme un substituant d'hydroxyle sélectionné parmi un atome d'hydrogène, un alkyle inférieur C1-C5 éventuellement substitué et un acyle.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | SUBSTITUTED 2-(5-HYDROXY-2-METHYL-1N-INDOLE-3-IL) ACETIC ACIDS AND ETHERS THEREOF AND THE USE OF SAME TO TREAT VIRAL DISEASES |
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