A PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE N-BENZYL-3 HYDROXYPYRROLIDINES
The present invention relates to a facile, highly efficient and economical process for the preparation of optically active N-benzyl-3-hydroxypyrrolidine in high yield from a naturally occurring alkaloid vasicine. The natural alkaloid vasicine is used as a precursor of (S)-N-benzyl-3-hydroxypyrrolidi...
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng ; fre |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | AGA, MUSHTAQ, AHMAD KUMAR, BRIJESH SETHI, VIJAY, KUMAR ANDOTRA, SAMAR, SINGH TANEJA, SUBHASH, CHANDRA QAZI, GULHA, NABI |
| description | The present invention relates to a facile, highly efficient and economical process for the preparation of optically active N-benzyl-3-hydroxypyrrolidine in high yield from a naturally occurring alkaloid vasicine. The natural alkaloid vasicine is used as a precursor of (S)-N-benzyl-3-hydroxypyrrolidine and (R)-N-benzyl-3-hydroxypyrrolidines which can easily be sourced from the medicinal plant Adatoda vasica by the method known in the art and transformed to optical isomers (R) and (S)-N-benzyl-3-hydroxypyrrolidine by the method described in the present invention.
La présente invention concerne un procédé facile, très efficace et économique de préparation de N-benzyl-3-hydroxypyrrolidine optiquement active avec un rendement élevé à partir d'un alcaloïde naturel, la vasicine. Cet alcaloïde naturel, la vasicine, est utilisé comme précurseur de (S)-N-benzyl-3-hydroxypyrrolidine et de (R)-N-benzyl-3-hydroxypyrrolidines, que l'on peut facilement extraire de la plante médicinale Adatoda vasica par le procédé connu dans la technique et transformer en isomères optiques (R) et (S)-N-benzyl-3-hydroxypyrrolidine par le procédé décrit dans la présente invention. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_WO2010058429A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>WO2010058429A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_WO2010058429A13</originalsourceid><addsrcrecordid>eNrjZAhwVAgI8nd2DQ5WcPMPUgjxcAXyXQMcgxxDPP39FPzdFPwDQjydHX18IhUcnUM8w1wV_HSdXP2iIn10jRU8Il2C_CMiAyKDgvx9PF08_VyDeRhY0xJzilN5oTQ3g7Kba4izh25qQX58anFBYnJqXmpJfLi_kYGhgYGphYmRpaOhMXGqAEGFMD4</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>A PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE N-BENZYL-3 HYDROXYPYRROLIDINES</title><source>esp@cenet</source><creator>AGA, MUSHTAQ, AHMAD ; KUMAR, BRIJESH ; SETHI, VIJAY, KUMAR ; ANDOTRA, SAMAR, SINGH ; TANEJA, SUBHASH, CHANDRA ; QAZI, GULHA, NABI</creator><creatorcontrib>AGA, MUSHTAQ, AHMAD ; KUMAR, BRIJESH ; SETHI, VIJAY, KUMAR ; ANDOTRA, SAMAR, SINGH ; TANEJA, SUBHASH, CHANDRA ; QAZI, GULHA, NABI</creatorcontrib><description>The present invention relates to a facile, highly efficient and economical process for the preparation of optically active N-benzyl-3-hydroxypyrrolidine in high yield from a naturally occurring alkaloid vasicine. The natural alkaloid vasicine is used as a precursor of (S)-N-benzyl-3-hydroxypyrrolidine and (R)-N-benzyl-3-hydroxypyrrolidines which can easily be sourced from the medicinal plant Adatoda vasica by the method known in the art and transformed to optical isomers (R) and (S)-N-benzyl-3-hydroxypyrrolidine by the method described in the present invention.
La présente invention concerne un procédé facile, très efficace et économique de préparation de N-benzyl-3-hydroxypyrrolidine optiquement active avec un rendement élevé à partir d'un alcaloïde naturel, la vasicine. Cet alcaloïde naturel, la vasicine, est utilisé comme précurseur de (S)-N-benzyl-3-hydroxypyrrolidine et de (R)-N-benzyl-3-hydroxypyrrolidines, que l'on peut facilement extraire de la plante médicinale Adatoda vasica par le procédé connu dans la technique et transformer en isomères optiques (R) et (S)-N-benzyl-3-hydroxypyrrolidine par le procédé décrit dans la présente invention.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2010</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20100527&DB=EPODOC&CC=WO&NR=2010058429A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20100527&DB=EPODOC&CC=WO&NR=2010058429A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>AGA, MUSHTAQ, AHMAD</creatorcontrib><creatorcontrib>KUMAR, BRIJESH</creatorcontrib><creatorcontrib>SETHI, VIJAY, KUMAR</creatorcontrib><creatorcontrib>ANDOTRA, SAMAR, SINGH</creatorcontrib><creatorcontrib>TANEJA, SUBHASH, CHANDRA</creatorcontrib><creatorcontrib>QAZI, GULHA, NABI</creatorcontrib><title>A PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE N-BENZYL-3 HYDROXYPYRROLIDINES</title><description>The present invention relates to a facile, highly efficient and economical process for the preparation of optically active N-benzyl-3-hydroxypyrrolidine in high yield from a naturally occurring alkaloid vasicine. The natural alkaloid vasicine is used as a precursor of (S)-N-benzyl-3-hydroxypyrrolidine and (R)-N-benzyl-3-hydroxypyrrolidines which can easily be sourced from the medicinal plant Adatoda vasica by the method known in the art and transformed to optical isomers (R) and (S)-N-benzyl-3-hydroxypyrrolidine by the method described in the present invention.
La présente invention concerne un procédé facile, très efficace et économique de préparation de N-benzyl-3-hydroxypyrrolidine optiquement active avec un rendement élevé à partir d'un alcaloïde naturel, la vasicine. Cet alcaloïde naturel, la vasicine, est utilisé comme précurseur de (S)-N-benzyl-3-hydroxypyrrolidine et de (R)-N-benzyl-3-hydroxypyrrolidines, que l'on peut facilement extraire de la plante médicinale Adatoda vasica par le procédé connu dans la technique et transformer en isomères optiques (R) et (S)-N-benzyl-3-hydroxypyrrolidine par le procédé décrit dans la présente invention.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2010</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZAhwVAgI8nd2DQ5WcPMPUgjxcAXyXQMcgxxDPP39FPzdFPwDQjydHX18IhUcnUM8w1wV_HSdXP2iIn10jRU8Il2C_CMiAyKDgvx9PF08_VyDeRhY0xJzilN5oTQ3g7Kba4izh25qQX58anFBYnJqXmpJfLi_kYGhgYGphYmRpaOhMXGqAEGFMD4</recordid><startdate>20100527</startdate><enddate>20100527</enddate><creator>AGA, MUSHTAQ, AHMAD</creator><creator>KUMAR, BRIJESH</creator><creator>SETHI, VIJAY, KUMAR</creator><creator>ANDOTRA, SAMAR, SINGH</creator><creator>TANEJA, SUBHASH, CHANDRA</creator><creator>QAZI, GULHA, NABI</creator><scope>EVB</scope></search><sort><creationdate>20100527</creationdate><title>A PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE N-BENZYL-3 HYDROXYPYRROLIDINES</title><author>AGA, MUSHTAQ, AHMAD ; KUMAR, BRIJESH ; SETHI, VIJAY, KUMAR ; ANDOTRA, SAMAR, SINGH ; TANEJA, SUBHASH, CHANDRA ; QAZI, GULHA, NABI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2010058429A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2010</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>AGA, MUSHTAQ, AHMAD</creatorcontrib><creatorcontrib>KUMAR, BRIJESH</creatorcontrib><creatorcontrib>SETHI, VIJAY, KUMAR</creatorcontrib><creatorcontrib>ANDOTRA, SAMAR, SINGH</creatorcontrib><creatorcontrib>TANEJA, SUBHASH, CHANDRA</creatorcontrib><creatorcontrib>QAZI, GULHA, NABI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>AGA, MUSHTAQ, AHMAD</au><au>KUMAR, BRIJESH</au><au>SETHI, VIJAY, KUMAR</au><au>ANDOTRA, SAMAR, SINGH</au><au>TANEJA, SUBHASH, CHANDRA</au><au>QAZI, GULHA, NABI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>A PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE N-BENZYL-3 HYDROXYPYRROLIDINES</title><date>2010-05-27</date><risdate>2010</risdate><abstract>The present invention relates to a facile, highly efficient and economical process for the preparation of optically active N-benzyl-3-hydroxypyrrolidine in high yield from a naturally occurring alkaloid vasicine. The natural alkaloid vasicine is used as a precursor of (S)-N-benzyl-3-hydroxypyrrolidine and (R)-N-benzyl-3-hydroxypyrrolidines which can easily be sourced from the medicinal plant Adatoda vasica by the method known in the art and transformed to optical isomers (R) and (S)-N-benzyl-3-hydroxypyrrolidine by the method described in the present invention.
La présente invention concerne un procédé facile, très efficace et économique de préparation de N-benzyl-3-hydroxypyrrolidine optiquement active avec un rendement élevé à partir d'un alcaloïde naturel, la vasicine. Cet alcaloïde naturel, la vasicine, est utilisé comme précurseur de (S)-N-benzyl-3-hydroxypyrrolidine et de (R)-N-benzyl-3-hydroxypyrrolidines, que l'on peut facilement extraire de la plante médicinale Adatoda vasica par le procédé connu dans la technique et transformer en isomères optiques (R) et (S)-N-benzyl-3-hydroxypyrrolidine par le procédé décrit dans la présente invention.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng ; fre |
| recordid | cdi_epo_espacenet_WO2010058429A1 |
| source | esp@cenet |
| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY |
| title | A PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE N-BENZYL-3 HYDROXYPYRROLIDINES |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T09%3A04%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=AGA,%20MUSHTAQ,%20AHMAD&rft.date=2010-05-27&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EWO2010058429A1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |