ISOLATION OF MICROBUBBLES OF SELECTED SIZE RANGE FROM POLYDISPERSE MICROBUBBLES
In one aspect of the disclosed subject matter, a method for isolating target microbubbles having a predetermined size range from polydisperse microbubbles is disclosed. The method includes applying a first centrifugal field having a first field strength to a suspension comprising the polydisperse mi...
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| creator | KWAN, JAMES, JING SIRSI, SHASHANK, RAMESH CHEN, CHERRY FESHITAN, JAMEEL, ADEBAYO BORDEN, MARK, A |
| description | In one aspect of the disclosed subject matter, a method for isolating target microbubbles having a predetermined size range from polydisperse microbubbles is disclosed. The method includes applying a first centrifugal field having a first field strength to a suspension comprising the polydisperse microbubbles for a first duration of time, thereby forming a first infranatant comprising at least a portion of target microbubbles and a first supernatant cake comprising microbubbles having a greater size than the target microbubbles; removing the first supernatant cake; applying a second centrifugal field having a second field strength to the first infranatant for a second duration of time, the second field strength being greater than the first field strength, thereby forming a second supernatant cake comprising at least a portion of the target microbubbles and second infranatant comprising microbubbles having a smaller size than the target microbubbles; and isolating the second supernatant cake. In another aspect of the disclosed subject matter, a method for performing high frequency ultrasonic imaging using isolated microbubbles is provided.
La présente invention concerne, dans un aspect, un procédé destiné à isoler des microbulles cibles ayant une plage de dimension prédéterminée à partir de microbulles polydispersées. Le procédé consiste à appliquer un premier champ centrifuge, ayant une première intensité de champ, à une suspension comprenant les microbulles polydispersées pendant un premier laps de temps, formant ainsi un premier infranageant comprenant au moins une partie de microbulles cibles et un premier gâteau surnageant comprenant des microbulles dont la dimension est supérieure aux microbulles cibles ; éliminer le premier gâteau surnageant ; appliquer un second champ centrifuge, ayant une seconde intensité de champ, au premier infranageant pendant un second laps de temps, la seconde intensité de champ étant supérieure à la première intensité de champ, formant ainsi un second gâteau supernageant comprenant au moins une partie des microbulles cibles et un second infranageant comprenant les microbulles cibles dont la dimension est inférieure aux microbulles cibles ; et isoler le second gâteau supernageant. L'invention concerne, dans un autre aspect, un procédé de réalisation d'une imagerie ultrasonore haute fréquence à l'aide de microbulles isolées. |
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La présente invention concerne, dans un aspect, un procédé destiné à isoler des microbulles cibles ayant une plage de dimension prédéterminée à partir de microbulles polydispersées. Le procédé consiste à appliquer un premier champ centrifuge, ayant une première intensité de champ, à une suspension comprenant les microbulles polydispersées pendant un premier laps de temps, formant ainsi un premier infranageant comprenant au moins une partie de microbulles cibles et un premier gâteau surnageant comprenant des microbulles dont la dimension est supérieure aux microbulles cibles ; éliminer le premier gâteau surnageant ; appliquer un second champ centrifuge, ayant une seconde intensité de champ, au premier infranageant pendant un second laps de temps, la seconde intensité de champ étant supérieure à la première intensité de champ, formant ainsi un second gâteau supernageant comprenant au moins une partie des microbulles cibles et un second infranageant comprenant les microbulles cibles dont la dimension est inférieure aux microbulles cibles ; et isoler le second gâteau supernageant. L'invention concerne, dans un autre aspect, un procédé de réalisation d'une imagerie ultrasonore haute fréquence à l'aide de microbulles isolées.</description><language>eng ; fre</language><subject>DIAGNOSIS ; HUMAN NECESSITIES ; HYGIENE ; IDENTIFICATION ; MEDICAL OR VETERINARY SCIENCE ; SURGERY</subject><creationdate>2010</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20100318&DB=EPODOC&CC=WO&NR=2010030779A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20100318&DB=EPODOC&CC=WO&NR=2010030779A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KWAN, JAMES, JING</creatorcontrib><creatorcontrib>SIRSI, SHASHANK, RAMESH</creatorcontrib><creatorcontrib>CHEN, CHERRY</creatorcontrib><creatorcontrib>FESHITAN, JAMEEL, ADEBAYO</creatorcontrib><creatorcontrib>BORDEN, MARK, A</creatorcontrib><title>ISOLATION OF MICROBUBBLES OF SELECTED SIZE RANGE FROM POLYDISPERSE MICROBUBBLES</title><description>In one aspect of the disclosed subject matter, a method for isolating target microbubbles having a predetermined size range from polydisperse microbubbles is disclosed. The method includes applying a first centrifugal field having a first field strength to a suspension comprising the polydisperse microbubbles for a first duration of time, thereby forming a first infranatant comprising at least a portion of target microbubbles and a first supernatant cake comprising microbubbles having a greater size than the target microbubbles; removing the first supernatant cake; applying a second centrifugal field having a second field strength to the first infranatant for a second duration of time, the second field strength being greater than the first field strength, thereby forming a second supernatant cake comprising at least a portion of the target microbubbles and second infranatant comprising microbubbles having a smaller size than the target microbubbles; and isolating the second supernatant cake. In another aspect of the disclosed subject matter, a method for performing high frequency ultrasonic imaging using isolated microbubbles is provided.
La présente invention concerne, dans un aspect, un procédé destiné à isoler des microbulles cibles ayant une plage de dimension prédéterminée à partir de microbulles polydispersées. Le procédé consiste à appliquer un premier champ centrifuge, ayant une première intensité de champ, à une suspension comprenant les microbulles polydispersées pendant un premier laps de temps, formant ainsi un premier infranageant comprenant au moins une partie de microbulles cibles et un premier gâteau surnageant comprenant des microbulles dont la dimension est supérieure aux microbulles cibles ; éliminer le premier gâteau surnageant ; appliquer un second champ centrifuge, ayant une seconde intensité de champ, au premier infranageant pendant un second laps de temps, la seconde intensité de champ étant supérieure à la première intensité de champ, formant ainsi un second gâteau supernageant comprenant au moins une partie des microbulles cibles et un second infranageant comprenant les microbulles cibles dont la dimension est inférieure aux microbulles cibles ; et isoler le second gâteau supernageant. L'invention concerne, dans un autre aspect, un procédé de réalisation d'une imagerie ultrasonore haute fréquence à l'aide de microbulles isolées.</description><subject>DIAGNOSIS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>IDENTIFICATION</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>SURGERY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2010</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZPD3DPb3cQzx9PdT8HdT8PV0DvJ3CnVy8nENBvGDXX1cnUNcXRSCPaNcFYIc_dxdFdyC_H0VAvx9Il08gwNcg4JdUXTxMLCmJeYUp_JCaW4GZTfXEGcP3dSC_PjU4oLE5NS81JL4cH8jA0MDA2MDc3NLR0Nj4lQBAA-ZL9Y</recordid><startdate>20100318</startdate><enddate>20100318</enddate><creator>KWAN, JAMES, JING</creator><creator>SIRSI, SHASHANK, RAMESH</creator><creator>CHEN, CHERRY</creator><creator>FESHITAN, JAMEEL, ADEBAYO</creator><creator>BORDEN, MARK, A</creator><scope>EVB</scope></search><sort><creationdate>20100318</creationdate><title>ISOLATION OF MICROBUBBLES OF SELECTED SIZE RANGE FROM POLYDISPERSE MICROBUBBLES</title><author>KWAN, JAMES, JING ; SIRSI, SHASHANK, RAMESH ; CHEN, CHERRY ; FESHITAN, JAMEEL, ADEBAYO ; BORDEN, MARK, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2010030779A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2010</creationdate><topic>DIAGNOSIS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>IDENTIFICATION</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>SURGERY</topic><toplevel>online_resources</toplevel><creatorcontrib>KWAN, JAMES, JING</creatorcontrib><creatorcontrib>SIRSI, SHASHANK, RAMESH</creatorcontrib><creatorcontrib>CHEN, CHERRY</creatorcontrib><creatorcontrib>FESHITAN, JAMEEL, ADEBAYO</creatorcontrib><creatorcontrib>BORDEN, MARK, A</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>KWAN, JAMES, JING</au><au>SIRSI, SHASHANK, RAMESH</au><au>CHEN, CHERRY</au><au>FESHITAN, JAMEEL, ADEBAYO</au><au>BORDEN, MARK, A</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>ISOLATION OF MICROBUBBLES OF SELECTED SIZE RANGE FROM POLYDISPERSE MICROBUBBLES</title><date>2010-03-18</date><risdate>2010</risdate><abstract>In one aspect of the disclosed subject matter, a method for isolating target microbubbles having a predetermined size range from polydisperse microbubbles is disclosed. The method includes applying a first centrifugal field having a first field strength to a suspension comprising the polydisperse microbubbles for a first duration of time, thereby forming a first infranatant comprising at least a portion of target microbubbles and a first supernatant cake comprising microbubbles having a greater size than the target microbubbles; removing the first supernatant cake; applying a second centrifugal field having a second field strength to the first infranatant for a second duration of time, the second field strength being greater than the first field strength, thereby forming a second supernatant cake comprising at least a portion of the target microbubbles and second infranatant comprising microbubbles having a smaller size than the target microbubbles; and isolating the second supernatant cake. In another aspect of the disclosed subject matter, a method for performing high frequency ultrasonic imaging using isolated microbubbles is provided.
La présente invention concerne, dans un aspect, un procédé destiné à isoler des microbulles cibles ayant une plage de dimension prédéterminée à partir de microbulles polydispersées. Le procédé consiste à appliquer un premier champ centrifuge, ayant une première intensité de champ, à une suspension comprenant les microbulles polydispersées pendant un premier laps de temps, formant ainsi un premier infranageant comprenant au moins une partie de microbulles cibles et un premier gâteau surnageant comprenant des microbulles dont la dimension est supérieure aux microbulles cibles ; éliminer le premier gâteau surnageant ; appliquer un second champ centrifuge, ayant une seconde intensité de champ, au premier infranageant pendant un second laps de temps, la seconde intensité de champ étant supérieure à la première intensité de champ, formant ainsi un second gâteau supernageant comprenant au moins une partie des microbulles cibles et un second infranageant comprenant les microbulles cibles dont la dimension est inférieure aux microbulles cibles ; et isoler le second gâteau supernageant. L'invention concerne, dans un autre aspect, un procédé de réalisation d'une imagerie ultrasonore haute fréquence à l'aide de microbulles isolées.</abstract><oa>free_for_read</oa></addata></record> |
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| title | ISOLATION OF MICROBUBBLES OF SELECTED SIZE RANGE FROM POLYDISPERSE MICROBUBBLES |
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