2-ALKYL-6-CYCLOAMINO-3-(PYRIDIN-4-YL)IMIDAZO[1,2-IB]-PYRIDAZINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC APPLICATION THEREOF
The invention relates to 2-alkyl-6-cycloamino-3-(pyridin-4-yl)imidazo[1,2- b]pyridazine derivatives of the general formula (I) where: R2 is a C1-6-alkyl, C3.7-cycloalkyl, C3-7-cycloalkyl-C1-4-alkyl, C1-4-alkyloxy- C-M-alkyl, C3-7-cycloalkyloxy-C1-4-alkyl> C3.7-cycloalkyl-C1-4-alkyloxy-C1-4-alkyl,...
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| creator | COTE-DES COMBES, SYLVAIN ZHAO, QIUXIA GAO, ZHONGLI ALMARIO GARCIA, ANTONIO GILBERT, JEAN-FRANCOIS PACAUD, CHRISTOPHE DAVIS, LARRY PUECH, FREDERIC BURNIER, PHILIPPE CHIANG, YULIN |
| description | The invention relates to 2-alkyl-6-cycloamino-3-(pyridin-4-yl)imidazo[1,2- b]pyridazine derivatives of the general formula (I) where: R2 is a C1-6-alkyl, C3.7-cycloalkyl, C3-7-cycloalkyl-C1-4-alkyl, C1-4-alkyloxy- C-M-alkyl, C3-7-cycloalkyloxy-C1-4-alkyl> C3.7-cycloalkyl-C1-4-alkyloxy-C1-4-alkyl, hydroxy-C1-6-alkyl, C1-4-fluoroalkyl group; R3 is a hydrogen atom or a substituent selected from halogen atoms and the C1-3 alkyl, -NR4R5, hydroxyl or C1-4 alkyloxy groups ; A is a C-1-7-alkylene group optionally substituted by one or two Ra groups; B is a C-1-7-alkylene group optionally substituted by one or two Rb groups; L is either a nitrogen atom optionally substituted by an Rc or Rd group or a carbon atom substituted by an Re1 group and an Rd group or by two Re2 groups; Rd is a group selected from a hydrogen atom or a C1-6-alkyl, C3-7-cycloalkyl, C3-7- cycloalkyl-C1-6-alkyl, C1-6-alkylthio-C-1-6-alkyl, C1-6-alkyloxy-C1-6-alkyl, C1- 6-fluoroalkyl, hydroxy-C1-6-alkyl group; Rf is a C1-6-alkyl, C3-7-cycloalkyl, C3-7-cycloalkyl-C1-6-alkyl, C1-6-alkyloxy-C1-6-alkyl, C3-7-cycloalkyloxy-C1-4-alkyl, C3-7- cycloalkyl-C1-4-alkyloxy-C1-4-alkyl, hydroxy-C1-6-alkyl, C1-6-fluoroalkyl or benzyl group. The invention also relates to a method for preparing same and to the therapeutic application thereof.
L'invention concerne des dérivés de 2-alkyl-6-cycloamino-3-(pyridin-4-yl)imidazo[1,2- b]pyridazine, répondant à la formule générale (I) dans laquelle R2 représente un groupe C1-6-alkyle, C3.7-cycloalkyle, C3-7-cycloalkyl-C1-4-alkyle, C1-4-alkyloxy- C-M-alkyle, C3-7-cycloalkyloxy-C1-4-alkyle> C3.7-cycloalkyl-C1-4-alkyloxy-C1-4-alkyle, hydroxy-C1-6-alkyle, C1-4-fluoroalkyle; R3 représente un atome d'hydrogène ou un substituant choisi parmi les atomes d'halogène et les groupes C1-3 alkyle, -NR4R5, hydroxyle ou C1-4 alkyloxy; A représente un groupe C-1-7-alkylène éventuellement substitué par un ou deux groupes Ra; B représente un groupe C1-7-alkylène éventuellement substitué par un groupe Rb; L représente soit un atome d'azote éventuellement substitué par un groupe Rc ou Rd, soit un atome de carbone substitué par un groupe Re1 et un groupe Rd ou deux groupes Re2; Rd représente un groupe choisi parmi l'atome d'hydrogène et les groupes C1-6-alkyle, C3-7-cycloalkyle, C3-7- cycloalkyl-C1-6-alkyle, C1-6-alkylthio-C-1-6-alkyle, C1-6-alkyloxy-C1-6-alkyle, C1- 6-fluoroalkyle, hydroxy-C1-6-alkyle; Rf représente un groupe C1-6-alkyle, C3-7-cycloalkyle, C3-7-cycloalkyle-C1-6-alkyle, C1-6-al |
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| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_WO2010018327A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>WO2010018327A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_WO2010018327A13</originalsourceid><addsrcrecordid>eNqNirsKwjAUQLs4iPoPAReFXuhD1PWapvRiTEKslVakFImTaKH-gv-tFBc3p8PhnKH3igDltpSwBF5yqXFHSkMMM1NaSkjBAko5px0lWOlT6EdAmzP0EStSgiXCUoE5FWLvM2OFQfsxrVieCSt06jNUSS9oxCEnztAYSfxnGnuDa3Pr3OTLkTdNRc4zcO2jdl3bXNzdPeujjoIwCMJ1HK0wjP-73lGWPjA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>2-ALKYL-6-CYCLOAMINO-3-(PYRIDIN-4-YL)IMIDAZO[1,2-IB]-PYRIDAZINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC APPLICATION THEREOF</title><source>esp@cenet</source><creator>COTE-DES COMBES, SYLVAIN ; ZHAO, QIUXIA ; GAO, ZHONGLI ; ALMARIO GARCIA, ANTONIO ; GILBERT, JEAN-FRANCOIS ; PACAUD, CHRISTOPHE ; DAVIS, LARRY ; PUECH, FREDERIC ; BURNIER, PHILIPPE ; CHIANG, YULIN</creator><creatorcontrib>COTE-DES COMBES, SYLVAIN ; ZHAO, QIUXIA ; GAO, ZHONGLI ; ALMARIO GARCIA, ANTONIO ; GILBERT, JEAN-FRANCOIS ; PACAUD, CHRISTOPHE ; DAVIS, LARRY ; PUECH, FREDERIC ; BURNIER, PHILIPPE ; CHIANG, YULIN</creatorcontrib><description>The invention relates to 2-alkyl-6-cycloamino-3-(pyridin-4-yl)imidazo[1,2- b]pyridazine derivatives of the general formula (I) where: R2 is a C1-6-alkyl, C3.7-cycloalkyl, C3-7-cycloalkyl-C1-4-alkyl, C1-4-alkyloxy- C-M-alkyl, C3-7-cycloalkyloxy-C1-4-alkyl> C3.7-cycloalkyl-C1-4-alkyloxy-C1-4-alkyl, hydroxy-C1-6-alkyl, C1-4-fluoroalkyl group; R3 is a hydrogen atom or a substituent selected from halogen atoms and the C1-3 alkyl, -NR4R5, hydroxyl or C1-4 alkyloxy groups ; A is a C-1-7-alkylene group optionally substituted by one or two Ra groups; B is a C-1-7-alkylene group optionally substituted by one or two Rb groups; L is either a nitrogen atom optionally substituted by an Rc or Rd group or a carbon atom substituted by an Re1 group and an Rd group or by two Re2 groups; Rd is a group selected from a hydrogen atom or a C1-6-alkyl, C3-7-cycloalkyl, C3-7- cycloalkyl-C1-6-alkyl, C1-6-alkylthio-C-1-6-alkyl, C1-6-alkyloxy-C1-6-alkyl, C1- 6-fluoroalkyl, hydroxy-C1-6-alkyl group; Rf is a C1-6-alkyl, C3-7-cycloalkyl, C3-7-cycloalkyl-C1-6-alkyl, C1-6-alkyloxy-C1-6-alkyl, C3-7-cycloalkyloxy-C1-4-alkyl, C3-7- cycloalkyl-C1-4-alkyloxy-C1-4-alkyl, hydroxy-C1-6-alkyl, C1-6-fluoroalkyl or benzyl group. The invention also relates to a method for preparing same and to the therapeutic application thereof.
L'invention concerne des dérivés de 2-alkyl-6-cycloamino-3-(pyridin-4-yl)imidazo[1,2- b]pyridazine, répondant à la formule générale (I) dans laquelle R2 représente un groupe C1-6-alkyle, C3.7-cycloalkyle, C3-7-cycloalkyl-C1-4-alkyle, C1-4-alkyloxy- C-M-alkyle, C3-7-cycloalkyloxy-C1-4-alkyle> C3.7-cycloalkyl-C1-4-alkyloxy-C1-4-alkyle, hydroxy-C1-6-alkyle, C1-4-fluoroalkyle; R3 représente un atome d'hydrogène ou un substituant choisi parmi les atomes d'halogène et les groupes C1-3 alkyle, -NR4R5, hydroxyle ou C1-4 alkyloxy; A représente un groupe C-1-7-alkylène éventuellement substitué par un ou deux groupes Ra; B représente un groupe C1-7-alkylène éventuellement substitué par un groupe Rb; L représente soit un atome d'azote éventuellement substitué par un groupe Rc ou Rd, soit un atome de carbone substitué par un groupe Re1 et un groupe Rd ou deux groupes Re2; Rd représente un groupe choisi parmi l'atome d'hydrogène et les groupes C1-6-alkyle, C3-7-cycloalkyle, C3-7- cycloalkyl-C1-6-alkyle, C1-6-alkylthio-C-1-6-alkyle, C1-6-alkyloxy-C1-6-alkyle, C1- 6-fluoroalkyle, hydroxy-C1-6-alkyle; Rf représente un groupe C1-6-alkyle, C3-7-cycloalkyle, C3-7-cycloalkyle-C1-6-alkyle, C1-6-alkyloxy-C1-6-alkyle, C3-7-cycloalkyloxy-C1-4-alkyle, C3-7- cycloalkyl-C1-4-alkyloxy-C1-4-alkyle, hydroxy-C1-6-alkyle, C1-6-fluoroalkyle ou benzyle. Procédé de préparation et application en thérapeutique.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2010</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20100218&DB=EPODOC&CC=WO&NR=2010018327A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20100218&DB=EPODOC&CC=WO&NR=2010018327A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>COTE-DES COMBES, SYLVAIN</creatorcontrib><creatorcontrib>ZHAO, QIUXIA</creatorcontrib><creatorcontrib>GAO, ZHONGLI</creatorcontrib><creatorcontrib>ALMARIO GARCIA, ANTONIO</creatorcontrib><creatorcontrib>GILBERT, JEAN-FRANCOIS</creatorcontrib><creatorcontrib>PACAUD, CHRISTOPHE</creatorcontrib><creatorcontrib>DAVIS, LARRY</creatorcontrib><creatorcontrib>PUECH, FREDERIC</creatorcontrib><creatorcontrib>BURNIER, PHILIPPE</creatorcontrib><creatorcontrib>CHIANG, YULIN</creatorcontrib><title>2-ALKYL-6-CYCLOAMINO-3-(PYRIDIN-4-YL)IMIDAZO[1,2-IB]-PYRIDAZINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC APPLICATION THEREOF</title><description>The invention relates to 2-alkyl-6-cycloamino-3-(pyridin-4-yl)imidazo[1,2- b]pyridazine derivatives of the general formula (I) where: R2 is a C1-6-alkyl, C3.7-cycloalkyl, C3-7-cycloalkyl-C1-4-alkyl, C1-4-alkyloxy- C-M-alkyl, C3-7-cycloalkyloxy-C1-4-alkyl> C3.7-cycloalkyl-C1-4-alkyloxy-C1-4-alkyl, hydroxy-C1-6-alkyl, C1-4-fluoroalkyl group; R3 is a hydrogen atom or a substituent selected from halogen atoms and the C1-3 alkyl, -NR4R5, hydroxyl or C1-4 alkyloxy groups ; A is a C-1-7-alkylene group optionally substituted by one or two Ra groups; B is a C-1-7-alkylene group optionally substituted by one or two Rb groups; L is either a nitrogen atom optionally substituted by an Rc or Rd group or a carbon atom substituted by an Re1 group and an Rd group or by two Re2 groups; Rd is a group selected from a hydrogen atom or a C1-6-alkyl, C3-7-cycloalkyl, C3-7- cycloalkyl-C1-6-alkyl, C1-6-alkylthio-C-1-6-alkyl, C1-6-alkyloxy-C1-6-alkyl, C1- 6-fluoroalkyl, hydroxy-C1-6-alkyl group; Rf is a C1-6-alkyl, C3-7-cycloalkyl, C3-7-cycloalkyl-C1-6-alkyl, C1-6-alkyloxy-C1-6-alkyl, C3-7-cycloalkyloxy-C1-4-alkyl, C3-7- cycloalkyl-C1-4-alkyloxy-C1-4-alkyl, hydroxy-C1-6-alkyl, C1-6-fluoroalkyl or benzyl group. The invention also relates to a method for preparing same and to the therapeutic application thereof.
L'invention concerne des dérivés de 2-alkyl-6-cycloamino-3-(pyridin-4-yl)imidazo[1,2- b]pyridazine, répondant à la formule générale (I) dans laquelle R2 représente un groupe C1-6-alkyle, C3.7-cycloalkyle, C3-7-cycloalkyl-C1-4-alkyle, C1-4-alkyloxy- C-M-alkyle, C3-7-cycloalkyloxy-C1-4-alkyle> C3.7-cycloalkyl-C1-4-alkyloxy-C1-4-alkyle, hydroxy-C1-6-alkyle, C1-4-fluoroalkyle; R3 représente un atome d'hydrogène ou un substituant choisi parmi les atomes d'halogène et les groupes C1-3 alkyle, -NR4R5, hydroxyle ou C1-4 alkyloxy; A représente un groupe C-1-7-alkylène éventuellement substitué par un ou deux groupes Ra; B représente un groupe C1-7-alkylène éventuellement substitué par un groupe Rb; L représente soit un atome d'azote éventuellement substitué par un groupe Rc ou Rd, soit un atome de carbone substitué par un groupe Re1 et un groupe Rd ou deux groupes Re2; Rd représente un groupe choisi parmi l'atome d'hydrogène et les groupes C1-6-alkyle, C3-7-cycloalkyle, C3-7- cycloalkyl-C1-6-alkyle, C1-6-alkylthio-C-1-6-alkyle, C1-6-alkyloxy-C1-6-alkyle, C1- 6-fluoroalkyle, hydroxy-C1-6-alkyle; Rf représente un groupe C1-6-alkyle, C3-7-cycloalkyle, C3-7-cycloalkyle-C1-6-alkyle, C1-6-alkyloxy-C1-6-alkyle, C3-7-cycloalkyloxy-C1-4-alkyle, C3-7- cycloalkyl-C1-4-alkyloxy-C1-4-alkyle, hydroxy-C1-6-alkyle, C1-6-fluoroalkyle ou benzyle. Procédé de préparation et application en thérapeutique.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2010</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNirsKwjAUQLs4iPoPAReFXuhD1PWapvRiTEKslVakFImTaKH-gv-tFBc3p8PhnKH3igDltpSwBF5yqXFHSkMMM1NaSkjBAko5px0lWOlT6EdAmzP0EStSgiXCUoE5FWLvM2OFQfsxrVieCSt06jNUSS9oxCEnztAYSfxnGnuDa3Pr3OTLkTdNRc4zcO2jdl3bXNzdPeujjoIwCMJ1HK0wjP-73lGWPjA</recordid><startdate>20100218</startdate><enddate>20100218</enddate><creator>COTE-DES COMBES, SYLVAIN</creator><creator>ZHAO, QIUXIA</creator><creator>GAO, ZHONGLI</creator><creator>ALMARIO GARCIA, ANTONIO</creator><creator>GILBERT, JEAN-FRANCOIS</creator><creator>PACAUD, CHRISTOPHE</creator><creator>DAVIS, LARRY</creator><creator>PUECH, FREDERIC</creator><creator>BURNIER, PHILIPPE</creator><creator>CHIANG, YULIN</creator><scope>EVB</scope></search><sort><creationdate>20100218</creationdate><title>2-ALKYL-6-CYCLOAMINO-3-(PYRIDIN-4-YL)IMIDAZO[1,2-IB]-PYRIDAZINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC APPLICATION THEREOF</title><author>COTE-DES COMBES, SYLVAIN ; ZHAO, QIUXIA ; GAO, ZHONGLI ; ALMARIO GARCIA, ANTONIO ; GILBERT, JEAN-FRANCOIS ; PACAUD, CHRISTOPHE ; DAVIS, LARRY ; PUECH, FREDERIC ; BURNIER, PHILIPPE ; CHIANG, YULIN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2010018327A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2010</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>COTE-DES COMBES, SYLVAIN</creatorcontrib><creatorcontrib>ZHAO, QIUXIA</creatorcontrib><creatorcontrib>GAO, ZHONGLI</creatorcontrib><creatorcontrib>ALMARIO GARCIA, ANTONIO</creatorcontrib><creatorcontrib>GILBERT, JEAN-FRANCOIS</creatorcontrib><creatorcontrib>PACAUD, CHRISTOPHE</creatorcontrib><creatorcontrib>DAVIS, LARRY</creatorcontrib><creatorcontrib>PUECH, FREDERIC</creatorcontrib><creatorcontrib>BURNIER, PHILIPPE</creatorcontrib><creatorcontrib>CHIANG, YULIN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>COTE-DES COMBES, SYLVAIN</au><au>ZHAO, QIUXIA</au><au>GAO, ZHONGLI</au><au>ALMARIO GARCIA, ANTONIO</au><au>GILBERT, JEAN-FRANCOIS</au><au>PACAUD, CHRISTOPHE</au><au>DAVIS, LARRY</au><au>PUECH, FREDERIC</au><au>BURNIER, PHILIPPE</au><au>CHIANG, YULIN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>2-ALKYL-6-CYCLOAMINO-3-(PYRIDIN-4-YL)IMIDAZO[1,2-IB]-PYRIDAZINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC APPLICATION THEREOF</title><date>2010-02-18</date><risdate>2010</risdate><abstract>The invention relates to 2-alkyl-6-cycloamino-3-(pyridin-4-yl)imidazo[1,2- b]pyridazine derivatives of the general formula (I) where: R2 is a C1-6-alkyl, C3.7-cycloalkyl, C3-7-cycloalkyl-C1-4-alkyl, C1-4-alkyloxy- C-M-alkyl, C3-7-cycloalkyloxy-C1-4-alkyl> C3.7-cycloalkyl-C1-4-alkyloxy-C1-4-alkyl, hydroxy-C1-6-alkyl, C1-4-fluoroalkyl group; R3 is a hydrogen atom or a substituent selected from halogen atoms and the C1-3 alkyl, -NR4R5, hydroxyl or C1-4 alkyloxy groups ; A is a C-1-7-alkylene group optionally substituted by one or two Ra groups; B is a C-1-7-alkylene group optionally substituted by one or two Rb groups; L is either a nitrogen atom optionally substituted by an Rc or Rd group or a carbon atom substituted by an Re1 group and an Rd group or by two Re2 groups; Rd is a group selected from a hydrogen atom or a C1-6-alkyl, C3-7-cycloalkyl, C3-7- cycloalkyl-C1-6-alkyl, C1-6-alkylthio-C-1-6-alkyl, C1-6-alkyloxy-C1-6-alkyl, C1- 6-fluoroalkyl, hydroxy-C1-6-alkyl group; Rf is a C1-6-alkyl, C3-7-cycloalkyl, C3-7-cycloalkyl-C1-6-alkyl, C1-6-alkyloxy-C1-6-alkyl, C3-7-cycloalkyloxy-C1-4-alkyl, C3-7- cycloalkyl-C1-4-alkyloxy-C1-4-alkyl, hydroxy-C1-6-alkyl, C1-6-fluoroalkyl or benzyl group. The invention also relates to a method for preparing same and to the therapeutic application thereof.
L'invention concerne des dérivés de 2-alkyl-6-cycloamino-3-(pyridin-4-yl)imidazo[1,2- b]pyridazine, répondant à la formule générale (I) dans laquelle R2 représente un groupe C1-6-alkyle, C3.7-cycloalkyle, C3-7-cycloalkyl-C1-4-alkyle, C1-4-alkyloxy- C-M-alkyle, C3-7-cycloalkyloxy-C1-4-alkyle> C3.7-cycloalkyl-C1-4-alkyloxy-C1-4-alkyle, hydroxy-C1-6-alkyle, C1-4-fluoroalkyle; R3 représente un atome d'hydrogène ou un substituant choisi parmi les atomes d'halogène et les groupes C1-3 alkyle, -NR4R5, hydroxyle ou C1-4 alkyloxy; A représente un groupe C-1-7-alkylène éventuellement substitué par un ou deux groupes Ra; B représente un groupe C1-7-alkylène éventuellement substitué par un groupe Rb; L représente soit un atome d'azote éventuellement substitué par un groupe Rc ou Rd, soit un atome de carbone substitué par un groupe Re1 et un groupe Rd ou deux groupes Re2; Rd représente un groupe choisi parmi l'atome d'hydrogène et les groupes C1-6-alkyle, C3-7-cycloalkyle, C3-7- cycloalkyl-C1-6-alkyle, C1-6-alkylthio-C-1-6-alkyle, C1-6-alkyloxy-C1-6-alkyle, C1- 6-fluoroalkyle, hydroxy-C1-6-alkyle; Rf représente un groupe C1-6-alkyle, C3-7-cycloalkyle, C3-7-cycloalkyle-C1-6-alkyle, C1-6-alkyloxy-C1-6-alkyle, C3-7-cycloalkyloxy-C1-4-alkyle, C3-7- cycloalkyl-C1-4-alkyloxy-C1-4-alkyle, hydroxy-C1-6-alkyle, C1-6-fluoroalkyle ou benzyle. Procédé de préparation et application en thérapeutique.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | 2-ALKYL-6-CYCLOAMINO-3-(PYRIDIN-4-YL)IMIDAZO[1,2-IB]-PYRIDAZINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC APPLICATION THEREOF |
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