MUTATED SEQUENCES OF HEPATITIS VIRUS B RELATED TO DRUG RESISTANCE, METHOD FOR THEIR EVALUATION AND USE THEREOF IN THE MEDICAL FIELD
The invention relates to the identification of new mutations or combinations thereof (mutation profiles) in the inverse transcriptase gene and/or in the surface antigen of hepatitis B virus (HBV) potentially related with the genotypic resistance in vitro and in vivo to the therapy with antiviral dru...
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| creator | VINCENTI, DONATELLA CAPOBIANCHI, MARIA ROSARIA PROSPERI, MATTIA ROZERA, GABRIELLA ABBATE, ISABELLA SOLMONE, MARIACARMELA |
| description | The invention relates to the identification of new mutations or combinations thereof (mutation profiles) in the inverse transcriptase gene and/or in the surface antigen of hepatitis B virus (HBV) potentially related with the genotypic resistance in vitro and in vivo to the therapy with antiviral drugs. In particular, the invention relates to methods for the genotypization of a viral population and for the subsequent correlation of such a genotypization to the fenotype features by an automated method, with the aim to bring to evidence the relationship between said mutations and the resistance to one or more antiviral agents. The invention also relates to methods for the use of the mutation profiles for diagnostic purposes and for the development of new drugs (drug design and modification of existing drugs), for the clinical treatment and for the definition of therapies to be administered.
L'invention porte sur l'identification de nouvelles mutations ou combinaisons de celles-ci (profils de mutation) dans le gène de la transcriptase inverse et/ou dans l'antigène de surface du virus de l'hépatite B (VHB) potentiellement lié à la résistance génotypique in vitro et in vivo à la thérapie par des médicaments antiviraux. En particulier, l'invention porte sur des méthodes pour le génotypage d'une population virale ou pour la corrélation ultérieure d'un tel génotypage aux caractéristiques de phénotype par un procédé automatisé, dans le but d'amener la preuve de la relation entre lesdites mutations et la résistance à un ou plusieurs agents antiviraux. L'invention porte également sur des méthodes d'utilisation des profils de mutation aux fins de diagnostic et pour l'élaboration de nouveaux médicaments (conception de médicament et modification de médicaments existants), pour le traitement clinique ou pour la définition de thérapies devant être administrées. |
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L'invention porte sur l'identification de nouvelles mutations ou combinaisons de celles-ci (profils de mutation) dans le gène de la transcriptase inverse et/ou dans l'antigène de surface du virus de l'hépatite B (VHB) potentiellement lié à la résistance génotypique in vitro et in vivo à la thérapie par des médicaments antiviraux. En particulier, l'invention porte sur des méthodes pour le génotypage d'une population virale ou pour la corrélation ultérieure d'un tel génotypage aux caractéristiques de phénotype par un procédé automatisé, dans le but d'amener la preuve de la relation entre lesdites mutations et la résistance à un ou plusieurs agents antiviraux. L'invention porte également sur des méthodes d'utilisation des profils de mutation aux fins de diagnostic et pour l'élaboration de nouveaux médicaments (conception de médicament et modification de médicaments existants), pour le traitement clinique ou pour la définition de thérapies devant être administrées.</description><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS OR TEST PAPERS THEREFOR ; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ; ENZYMOLOGY ; INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS ; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS ; METALLURGY ; MICROBIOLOGY ; MUTATION OR GENETIC ENGINEERING ; PHYSICS ; PROCESSES OF PREPARING SUCH COMPOSITIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2010</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20100211&DB=EPODOC&CC=WO&NR=2010016087A2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25546,76297</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20100211&DB=EPODOC&CC=WO&NR=2010016087A2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>VINCENTI, DONATELLA</creatorcontrib><creatorcontrib>CAPOBIANCHI, MARIA ROSARIA</creatorcontrib><creatorcontrib>PROSPERI, MATTIA</creatorcontrib><creatorcontrib>ROZERA, GABRIELLA</creatorcontrib><creatorcontrib>ABBATE, ISABELLA</creatorcontrib><creatorcontrib>SOLMONE, MARIACARMELA</creatorcontrib><title>MUTATED SEQUENCES OF HEPATITIS VIRUS B RELATED TO DRUG RESISTANCE, METHOD FOR THEIR EVALUATION AND USE THEREOF IN THE MEDICAL FIELD</title><description>The invention relates to the identification of new mutations or combinations thereof (mutation profiles) in the inverse transcriptase gene and/or in the surface antigen of hepatitis B virus (HBV) potentially related with the genotypic resistance in vitro and in vivo to the therapy with antiviral drugs. In particular, the invention relates to methods for the genotypization of a viral population and for the subsequent correlation of such a genotypization to the fenotype features by an automated method, with the aim to bring to evidence the relationship between said mutations and the resistance to one or more antiviral agents. The invention also relates to methods for the use of the mutation profiles for diagnostic purposes and for the development of new drugs (drug design and modification of existing drugs), for the clinical treatment and for the definition of therapies to be administered.
L'invention porte sur l'identification de nouvelles mutations ou combinaisons de celles-ci (profils de mutation) dans le gène de la transcriptase inverse et/ou dans l'antigène de surface du virus de l'hépatite B (VHB) potentiellement lié à la résistance génotypique in vitro et in vivo à la thérapie par des médicaments antiviraux. En particulier, l'invention porte sur des méthodes pour le génotypage d'une population virale ou pour la corrélation ultérieure d'un tel génotypage aux caractéristiques de phénotype par un procédé automatisé, dans le but d'amener la preuve de la relation entre lesdites mutations et la résistance à un ou plusieurs agents antiviraux. L'invention porte également sur des méthodes d'utilisation des profils de mutation aux fins de diagnostic et pour l'élaboration de nouveaux médicaments (conception de médicament et modification de médicaments existants), pour le traitement clinique ou pour la définition de thérapies devant être administrées.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS OR TEST PAPERS THEREFOR</subject><subject>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</subject><subject>ENZYMOLOGY</subject><subject>INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS</subject><subject>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PHYSICS</subject><subject>PROCESSES OF PREPARING SUCH COMPOSITIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2010</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjEEKwjAURLtxIeodPrhVSCuo29j82ECaaPJTl6VIXIkW6g28uKl4AFczw8ybafauA3FCAR7PAU2JHqyECk-cFCkPjXLBwwEc6u-MLAgXjil75YknYAU1UmUFSOuAKlQOsOE6pANrgBsBweNYOEzPyow2IUKVXINUqMU8m9y6-xAXP51lS4lUVuvYP9s49N01PuKrvdiC5YzlW7bf8WLz3-oD2Ys9UA</recordid><startdate>20100211</startdate><enddate>20100211</enddate><creator>VINCENTI, DONATELLA</creator><creator>CAPOBIANCHI, MARIA ROSARIA</creator><creator>PROSPERI, MATTIA</creator><creator>ROZERA, GABRIELLA</creator><creator>ABBATE, ISABELLA</creator><creator>SOLMONE, MARIACARMELA</creator><scope>EVB</scope></search><sort><creationdate>20100211</creationdate><title>MUTATED SEQUENCES OF HEPATITIS VIRUS B RELATED TO DRUG RESISTANCE, METHOD FOR THEIR EVALUATION AND USE THEREOF IN THE MEDICAL FIELD</title><author>VINCENTI, DONATELLA ; CAPOBIANCHI, MARIA ROSARIA ; PROSPERI, MATTIA ; ROZERA, GABRIELLA ; ABBATE, ISABELLA ; SOLMONE, MARIACARMELA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2010016087A23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2010</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS OR TEST PAPERS THEREFOR</topic><topic>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</topic><topic>ENZYMOLOGY</topic><topic>INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS</topic><topic>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PHYSICS</topic><topic>PROCESSES OF PREPARING SUCH COMPOSITIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>VINCENTI, DONATELLA</creatorcontrib><creatorcontrib>CAPOBIANCHI, MARIA ROSARIA</creatorcontrib><creatorcontrib>PROSPERI, MATTIA</creatorcontrib><creatorcontrib>ROZERA, GABRIELLA</creatorcontrib><creatorcontrib>ABBATE, ISABELLA</creatorcontrib><creatorcontrib>SOLMONE, MARIACARMELA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>VINCENTI, DONATELLA</au><au>CAPOBIANCHI, MARIA ROSARIA</au><au>PROSPERI, MATTIA</au><au>ROZERA, GABRIELLA</au><au>ABBATE, ISABELLA</au><au>SOLMONE, MARIACARMELA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>MUTATED SEQUENCES OF HEPATITIS VIRUS B RELATED TO DRUG RESISTANCE, METHOD FOR THEIR EVALUATION AND USE THEREOF IN THE MEDICAL FIELD</title><date>2010-02-11</date><risdate>2010</risdate><abstract>The invention relates to the identification of new mutations or combinations thereof (mutation profiles) in the inverse transcriptase gene and/or in the surface antigen of hepatitis B virus (HBV) potentially related with the genotypic resistance in vitro and in vivo to the therapy with antiviral drugs. In particular, the invention relates to methods for the genotypization of a viral population and for the subsequent correlation of such a genotypization to the fenotype features by an automated method, with the aim to bring to evidence the relationship between said mutations and the resistance to one or more antiviral agents. The invention also relates to methods for the use of the mutation profiles for diagnostic purposes and for the development of new drugs (drug design and modification of existing drugs), for the clinical treatment and for the definition of therapies to be administered.
L'invention porte sur l'identification de nouvelles mutations ou combinaisons de celles-ci (profils de mutation) dans le gène de la transcriptase inverse et/ou dans l'antigène de surface du virus de l'hépatite B (VHB) potentiellement lié à la résistance génotypique in vitro et in vivo à la thérapie par des médicaments antiviraux. En particulier, l'invention porte sur des méthodes pour le génotypage d'une population virale ou pour la corrélation ultérieure d'un tel génotypage aux caractéristiques de phénotype par un procédé automatisé, dans le but d'amener la preuve de la relation entre lesdites mutations et la résistance à un ou plusieurs agents antiviraux. L'invention porte également sur des méthodes d'utilisation des profils de mutation aux fins de diagnostic et pour l'élaboration de nouveaux médicaments (conception de médicament et modification de médicaments existants), pour le traitement clinique ou pour la définition de thérapies devant être administrées.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS VINEGAR WINE |
| title | MUTATED SEQUENCES OF HEPATITIS VIRUS B RELATED TO DRUG RESISTANCE, METHOD FOR THEIR EVALUATION AND USE THEREOF IN THE MEDICAL FIELD |
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