DISUBSTITUTED PHTHALAZINE HEDGEHOG PATHWAY ANTAGONISTS
The present invention provides novel 1,4-disubstituted phthalazine hedgehog pathway antagonists useful in the treatment of cancer. (I) wherein: R1 is hydrogen, fluoro, cyano, trifluoromethyl, methoxy, or trifluoromethoxy; R2 is hydrogen or methyl; and R3, R4, R5, R6 and R7 are independently hydrogen...
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| creator | HIPSKIND, PHILIP, ARTHUR WILSON, TAKAKO |
| description | The present invention provides novel 1,4-disubstituted phthalazine hedgehog pathway antagonists useful in the treatment of cancer. (I) wherein: R1 is hydrogen, fluoro, cyano, trifluoromethyl, methoxy, or trifluoromethoxy; R2 is hydrogen or methyl; and R3, R4, R5, R6 and R7 are independently hydrogen, chloro, fluoro, cyano, trifluoromethyl or trifluoromethoxy, provided that at least two of R3, R4, R5, R6 and R7 are hydrogen; or a pharmaceutically acceptable salt thereof.
La présente invention concerne de nouveaux antagonistes de la voie de la protéine Hedgehog de phtalazine 1,4-disubstituée utiles dans le traitement du cancer. |
| format | Patent |
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La présente invention concerne de nouveaux antagonistes de la voie de la protéine Hedgehog de phtalazine 1,4-disubstituée utiles dans le traitement du cancer.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2014</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDBz8QwOdQoO8QwJDXF1UQjwCPFw9HGM8vRzVfBwdXF39fB3VwhwDPEId4xUcPQLcXT39_MMDgnmYWBNS8wpTuWF0twMym6uIc4euqkF-fGpxQWJyal5qSXx4f5GBgaWhsYmpuYmjsbGxKkCAPFCKWA</recordid><startdate>20140904</startdate><enddate>20140904</enddate><creator>HIPSKIND, PHILIP, ARTHUR</creator><creator>WILSON, TAKAKO</creator><scope>EVB</scope></search><sort><creationdate>20140904</creationdate><title>DISUBSTITUTED PHTHALAZINE HEDGEHOG PATHWAY ANTAGONISTS</title><author>HIPSKIND, PHILIP, ARTHUR ; WILSON, TAKAKO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2009134574A33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2014</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>HIPSKIND, PHILIP, ARTHUR</creatorcontrib><creatorcontrib>WILSON, TAKAKO</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>HIPSKIND, PHILIP, ARTHUR</au><au>WILSON, TAKAKO</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>DISUBSTITUTED PHTHALAZINE HEDGEHOG PATHWAY ANTAGONISTS</title><date>2014-09-04</date><risdate>2014</risdate><abstract>The present invention provides novel 1,4-disubstituted phthalazine hedgehog pathway antagonists useful in the treatment of cancer. (I) wherein: R1 is hydrogen, fluoro, cyano, trifluoromethyl, methoxy, or trifluoromethoxy; R2 is hydrogen or methyl; and R3, R4, R5, R6 and R7 are independently hydrogen, chloro, fluoro, cyano, trifluoromethyl or trifluoromethoxy, provided that at least two of R3, R4, R5, R6 and R7 are hydrogen; or a pharmaceutically acceptable salt thereof.
La présente invention concerne de nouveaux antagonistes de la voie de la protéine Hedgehog de phtalazine 1,4-disubstituée utiles dans le traitement du cancer.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | DISUBSTITUTED PHTHALAZINE HEDGEHOG PATHWAY ANTAGONISTS |
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