AGENTS BINDING TO MEGALIN OR SEX HORMONE BINDING GLOBULIN AND COMPOSITIONS THEROF FOR TREATMENT OF STEROID DEPENDENT CANCERS

The present invention provides agents and compositions targeting megalin and/or sex hormone binding globulin (SHBG) for blocking steroid hormone transport into cells, and thereby provide a new method for treatment of steroid dependent cancers, including prostate cancer and breast cancer, such as est...

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Hauptverfasser: PEDERSEN, ANDERS HJELHOLT, HEJNAES, KIM
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creator PEDERSEN, ANDERS HJELHOLT
HEJNAES, KIM
description The present invention provides agents and compositions targeting megalin and/or sex hormone binding globulin (SHBG) for blocking steroid hormone transport into cells, and thereby provide a new method for treatment of steroid dependent cancers, including prostate cancer and breast cancer, such as estrogen receptor positive (ER+) breast cancer. La présente invention porte sur des agents et sur des compositions ciblant la mégaline et/ou la globuline de liaison à une hormone sexuelle (SHBG) pour bloquer un transport d'hormone stéroïde dans des cellules, et fournir ainsi un nouveau procédé pour le traitement de cancers dépendants des hormones stéroïdes, comprenant le cancer de la prostate et le cancer du sein, et tel qu'un cancer du sein positif au récepteur de l'oetrogène (ER+).
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title AGENTS BINDING TO MEGALIN OR SEX HORMONE BINDING GLOBULIN AND COMPOSITIONS THEROF FOR TREATMENT OF STEROID DEPENDENT CANCERS
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