APOPTOSIS SIGNAL-REGULATING KINASE 1 INHIBITORS

The present invention relates to apoptosis signal-regulating kinase 1 ("ASK1") inhibiting compounds of the formula (I); wherein the variables are as defined herein. The invention also relates to pharmaceutical compositions, kits and articles of manufacture comprising such compounds; method...

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Bibliographische Detailangaben
Hauptverfasser:	VASSAR, ANGIE, CHANG, EDCON, MCNEILL, MATTHEW, H, HIRANO, TAKEHIRO, DUONG, TRACY, TERAO, YOSHITO
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to apoptosis signal-regulating kinase 1 ("ASK1") inhibiting compounds of the formula (I); wherein the variables are as defined herein. The invention also relates to pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds. La présente invention concerne la kinase 1 de régulation de signal d'apoptose ("ASK1") inhibant des composés de la formule (I); dans laquelle les variables sont telles que définies par les présentes. L'invention concerne également des compositions pharmaceutiques, des kits et des articles de fabrication comportant de tels composés; des procédés et des intermédiaires utiles pour fabriquer les composés, et des procédés d'utilisation des composés.