ANTIBODIES, METHODS AND KITS FOR DIAGNOSING AND TREATING MELANOMA
A method of diagnosing melanoma and antibodies capable of same are disclosed. The method comprises contacting a cell of the subject with an antibody comprising an antigen recognition domain capable of binding to an MHC-I molecule being complexed with a tyrosinase peptide, wherein the antibody does n...
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| creator | HAUS-COHEN, MAYA REITER, YORAM COHEN, CYRIL KLECHEVSKY, EYNAV MICHAELI, YAEL |
| description | A method of diagnosing melanoma and antibodies capable of same are disclosed. The method comprises contacting a cell of the subject with an antibody comprising an antigen recognition domain capable of binding to an MHC-I molecule being complexed with a tyrosinase peptide, wherein the antibody does not bind the MHC-I in the absence of the complexed peptide, and wherein the antibody does not bind the peptide in an absence of the MHC, under conditions which allow immunocomplex formation, wherein a presence of the immunocomplex or level thereof is indicative of the melanoma. Methods for treating melanoma and antibodies capable of same are also disclosed. Pharmaceutical compositions comprising antibodies are also disclosed.
L'invention concerne un procédé de diagnostic de mélanomes et des anticorps pouvant agir de même. Le procédé comprend la mise en contact d'une cellule du sujet avec un anticorps comprenant un domaine de reconnaissance d'un antigène capable de se lier à une molécule MHC-I qui est complexée à un peptide de tyrosinase, l'anticorps ne se liant pas à MHC-I en l'absence du peptide complexé, et l'anticorps ne se liant pas au peptide en l'absence de MHC, dans des conditions qui permettent la formation d'un immuno-complexe, la présence de l'immuno-complexe ou le niveau de celui-ci étant indicatif d'un mélanome. L'invention concerne également des procédés de traitement de mélanomes et des anticorps pouvant agir de même. L'invention concerne également des compositions pharmaceutiques comprenant les anticorps. |
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L'invention concerne un procédé de diagnostic de mélanomes et des anticorps pouvant agir de même. Le procédé comprend la mise en contact d'une cellule du sujet avec un anticorps comprenant un domaine de reconnaissance d'un antigène capable de se lier à une molécule MHC-I qui est complexée à un peptide de tyrosinase, l'anticorps ne se liant pas à MHC-I en l'absence du peptide complexé, et l'anticorps ne se liant pas au peptide en l'absence de MHC, dans des conditions qui permettent la formation d'un immuno-complexe, la présence de l'immuno-complexe ou le niveau de celui-ci étant indicatif d'un mélanome. L'invention concerne également des procédés de traitement de mélanomes et des anticorps pouvant agir de même. L'invention concerne également des compositions pharmaceutiques comprenant les anticorps.</description><language>eng ; fre</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PHYSICS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; TESTING</subject><creationdate>2009</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20090108&DB=EPODOC&CC=WO&NR=2008120202A3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25562,76317</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20090108&DB=EPODOC&CC=WO&NR=2008120202A3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HAUS-COHEN, MAYA</creatorcontrib><creatorcontrib>REITER, YORAM</creatorcontrib><creatorcontrib>COHEN, CYRIL</creatorcontrib><creatorcontrib>KLECHEVSKY, EYNAV</creatorcontrib><creatorcontrib>MICHAELI, YAEL</creatorcontrib><title>ANTIBODIES, METHODS AND KITS FOR DIAGNOSING AND TREATING MELANOMA</title><description>A method of diagnosing melanoma and antibodies capable of same are disclosed. The method comprises contacting a cell of the subject with an antibody comprising an antigen recognition domain capable of binding to an MHC-I molecule being complexed with a tyrosinase peptide, wherein the antibody does not bind the MHC-I in the absence of the complexed peptide, and wherein the antibody does not bind the peptide in an absence of the MHC, under conditions which allow immunocomplex formation, wherein a presence of the immunocomplex or level thereof is indicative of the melanoma. Methods for treating melanoma and antibodies capable of same are also disclosed. Pharmaceutical compositions comprising antibodies are also disclosed.
L'invention concerne un procédé de diagnostic de mélanomes et des anticorps pouvant agir de même. Le procédé comprend la mise en contact d'une cellule du sujet avec un anticorps comprenant un domaine de reconnaissance d'un antigène capable de se lier à une molécule MHC-I qui est complexée à un peptide de tyrosinase, l'anticorps ne se liant pas à MHC-I en l'absence du peptide complexé, et l'anticorps ne se liant pas au peptide en l'absence de MHC, dans des conditions qui permettent la formation d'un immuno-complexe, la présence de l'immuno-complexe ou le niveau de celui-ci étant indicatif d'un mélanome. L'invention concerne également des procédés de traitement de mélanomes et des anticorps pouvant agir de même. L'invention concerne également des compositions pharmaceutiques comprenant les anticorps.</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>MEASURING</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PHYSICS</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>TESTING</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2009</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHB09AvxdPJ38XQN1lHwdQ3x8HcJVnD0c1Hw9gwJVnDzD1Jw8XR09_MP9vRzB4uHBLk6hoA4vq4-jn7-vo48DKxpiTnFqbxQmptB2c01xNlDN7UgPz61uCAxOTUvtSQ-3N_IwMDC0MgACB2NjYlTBQBYaCtz</recordid><startdate>20090108</startdate><enddate>20090108</enddate><creator>HAUS-COHEN, MAYA</creator><creator>REITER, YORAM</creator><creator>COHEN, CYRIL</creator><creator>KLECHEVSKY, EYNAV</creator><creator>MICHAELI, YAEL</creator><scope>EVB</scope></search><sort><creationdate>20090108</creationdate><title>ANTIBODIES, METHODS AND KITS FOR DIAGNOSING AND TREATING MELANOMA</title><author>HAUS-COHEN, MAYA ; REITER, YORAM ; COHEN, CYRIL ; KLECHEVSKY, EYNAV ; MICHAELI, YAEL</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2008120202A33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2009</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>MEASURING</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PHYSICS</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>TESTING</topic><toplevel>online_resources</toplevel><creatorcontrib>HAUS-COHEN, MAYA</creatorcontrib><creatorcontrib>REITER, YORAM</creatorcontrib><creatorcontrib>COHEN, CYRIL</creatorcontrib><creatorcontrib>KLECHEVSKY, EYNAV</creatorcontrib><creatorcontrib>MICHAELI, YAEL</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>HAUS-COHEN, MAYA</au><au>REITER, YORAM</au><au>COHEN, CYRIL</au><au>KLECHEVSKY, EYNAV</au><au>MICHAELI, YAEL</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>ANTIBODIES, METHODS AND KITS FOR DIAGNOSING AND TREATING MELANOMA</title><date>2009-01-08</date><risdate>2009</risdate><abstract>A method of diagnosing melanoma and antibodies capable of same are disclosed. The method comprises contacting a cell of the subject with an antibody comprising an antigen recognition domain capable of binding to an MHC-I molecule being complexed with a tyrosinase peptide, wherein the antibody does not bind the MHC-I in the absence of the complexed peptide, and wherein the antibody does not bind the peptide in an absence of the MHC, under conditions which allow immunocomplex formation, wherein a presence of the immunocomplex or level thereof is indicative of the melanoma. Methods for treating melanoma and antibodies capable of same are also disclosed. Pharmaceutical compositions comprising antibodies are also disclosed.
L'invention concerne un procédé de diagnostic de mélanomes et des anticorps pouvant agir de même. Le procédé comprend la mise en contact d'une cellule du sujet avec un anticorps comprenant un domaine de reconnaissance d'un antigène capable de se lier à une molécule MHC-I qui est complexée à un peptide de tyrosinase, l'anticorps ne se liant pas à MHC-I en l'absence du peptide complexé, et l'anticorps ne se liant pas au peptide en l'absence de MHC, dans des conditions qui permettent la formation d'un immuno-complexe, la présence de l'immuno-complexe ou le niveau de celui-ci étant indicatif d'un mélanome. L'invention concerne également des procédés de traitement de mélanomes et des anticorps pouvant agir de même. L'invention concerne également des compositions pharmaceutiques comprenant les anticorps.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TESTING |
| title | ANTIBODIES, METHODS AND KITS FOR DIAGNOSING AND TREATING MELANOMA |
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