A FUMARATE SALT OF 3-BROMO-N-{ (2S) -2- (4 -FLUOROPHENYL) -4- [3- (4-ACETYLPIPERAZIN-L-YL) AZETIDIN-1-YL] BUTYL} -N-METHYL-5- (TRIFLUOROMETHYL)BENZAMIDE FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS
The present invention relates to 3-bromo-N-{(2S)-2-(4-fluorophenyl)-4-[3-(4- acetylpiperazin-1-yl)azetidin-1-yl]butyl}-N-methyl-5-(trifluoromethyl)benzamide fumarate and crystalline forms thereof. The present invention also relates to the use of said salt and crystalline forms thereof for the treatm...
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| creator | FREDENWALL, MARLENE SIGFRIDSSON, CARL-GUSTAV |
| description | The present invention relates to 3-bromo-N-{(2S)-2-(4-fluorophenyl)-4-[3-(4- acetylpiperazin-1-yl)azetidin-1-yl]butyl}-N-methyl-5-(trifluoromethyl)benzamide fumarate and crystalline forms thereof. The present invention also relates to the use of said salt and crystalline forms thereof for the treatment of gastrointestinal disorders, pharmaceutical compositions containing it as well as processes for the preparation of the salt and novel crystalline forms thereof.
L'invention concerne du fumarate de 3-bromo-N-{(2S)-2-(4-fluorophényl)-4-[3-(4-acétylpipérazin-1-yl)azétidin-1-yl]butyl}-N-méthyl-5-(trifluorométhyl)benzamide et des formes cristallines de celui-ci. La présente invention concerne également l'utilisation du sel et de 5 formes cristallines de celui-ci pour le traitement de troubles gastro-intestinaux, des compositions pharmaceutiques le contenant de même que des procédés pour la préparation du sel, et de nouvelles formes cristallines de celui-ci. |
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L'invention concerne du fumarate de 3-bromo-N-{(2S)-2-(4-fluorophényl)-4-[3-(4-acétylpipérazin-1-yl)azétidin-1-yl]butyl}-N-méthyl-5-(trifluorométhyl)benzamide et des formes cristallines de celui-ci. La présente invention concerne également l'utilisation du sel et de 5 formes cristallines de celui-ci pour le traitement de troubles gastro-intestinaux, des compositions pharmaceutiques le contenant de même que des procédés pour la préparation du sel, et de nouvelles formes cristallines de celui-ci.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2008</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20081002&DB=EPODOC&CC=WO&NR=2008118091A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25544,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20081002&DB=EPODOC&CC=WO&NR=2008118091A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>FREDENWALL, MARLENE</creatorcontrib><creatorcontrib>SIGFRIDSSON, CARL-GUSTAV</creatorcontrib><title>A FUMARATE SALT OF 3-BROMO-N-{ (2S) -2- (4 -FLUOROPHENYL) -4- [3- (4-ACETYLPIPERAZIN-L-YL) AZETIDIN-1-YL] BUTYL} -N-METHYL-5- (TRIFLUOROMETHYL)BENZAMIDE FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS</title><description>The present invention relates to 3-bromo-N-{(2S)-2-(4-fluorophenyl)-4-[3-(4- acetylpiperazin-1-yl)azetidin-1-yl]butyl}-N-methyl-5-(trifluoromethyl)benzamide fumarate and crystalline forms thereof. The present invention also relates to the use of said salt and crystalline forms thereof for the treatment of gastrointestinal disorders, pharmaceutical compositions containing it as well as processes for the preparation of the salt and novel crystalline forms thereof.
L'invention concerne du fumarate de 3-bromo-N-{(2S)-2-(4-fluorophényl)-4-[3-(4-acétylpipérazin-1-yl)azétidin-1-yl]butyl}-N-méthyl-5-(trifluorométhyl)benzamide et des formes cristallines de celui-ci. La présente invention concerne également l'utilisation du sel et de 5 formes cristallines de celui-ci pour le traitement de troubles gastro-intestinaux, des compositions pharmaceutiques le contenant de même que des procédés pour la préparation du sel, et de nouvelles formes cristallines de celui-ci.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2008</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjs1KA0EQhPfiQdR3aPCSHBr2J4F47M32uAPzs8z0IrsiIch4Eg3Em_h-PpYT4wN4Kqr6q6Ivi28CNVoKJAyRjIBX0GAbvPXo8BMWdVwC1giLFaAyow9-6NlNJqcrhMfmdEHaskxm0AMHmrVDgyeAZhbdZVtl-wTtmJkvyLOWpZ8MrnNXgj6vnrNly24mqzsG5QNIzyCBSSy739fuKUrw2glH0Y4MdDr60HGI18XFy_71mG7-9Kq4VSzbHtPhfZeOh_1zeksfuwdfl-WmqjblXUVV8z_qB2NLTxE</recordid><startdate>20081002</startdate><enddate>20081002</enddate><creator>FREDENWALL, MARLENE</creator><creator>SIGFRIDSSON, CARL-GUSTAV</creator><scope>EVB</scope></search><sort><creationdate>20081002</creationdate><title>A FUMARATE SALT OF 3-BROMO-N-{ (2S) -2- (4 -FLUOROPHENYL) -4- [3- (4-ACETYLPIPERAZIN-L-YL) AZETIDIN-1-YL] BUTYL} -N-METHYL-5- (TRIFLUOROMETHYL)BENZAMIDE FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS</title><author>FREDENWALL, MARLENE ; SIGFRIDSSON, CARL-GUSTAV</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2008118091A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2008</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>FREDENWALL, MARLENE</creatorcontrib><creatorcontrib>SIGFRIDSSON, CARL-GUSTAV</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>FREDENWALL, MARLENE</au><au>SIGFRIDSSON, CARL-GUSTAV</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>A FUMARATE SALT OF 3-BROMO-N-{ (2S) -2- (4 -FLUOROPHENYL) -4- [3- (4-ACETYLPIPERAZIN-L-YL) AZETIDIN-1-YL] BUTYL} -N-METHYL-5- (TRIFLUOROMETHYL)BENZAMIDE FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS</title><date>2008-10-02</date><risdate>2008</risdate><abstract>The present invention relates to 3-bromo-N-{(2S)-2-(4-fluorophenyl)-4-[3-(4- acetylpiperazin-1-yl)azetidin-1-yl]butyl}-N-methyl-5-(trifluoromethyl)benzamide fumarate and crystalline forms thereof. The present invention also relates to the use of said salt and crystalline forms thereof for the treatment of gastrointestinal disorders, pharmaceutical compositions containing it as well as processes for the preparation of the salt and novel crystalline forms thereof.
L'invention concerne du fumarate de 3-bromo-N-{(2S)-2-(4-fluorophényl)-4-[3-(4-acétylpipérazin-1-yl)azétidin-1-yl]butyl}-N-méthyl-5-(trifluorométhyl)benzamide et des formes cristallines de celui-ci. La présente invention concerne également l'utilisation du sel et de 5 formes cristallines de celui-ci pour le traitement de troubles gastro-intestinaux, des compositions pharmaceutiques le contenant de même que des procédés pour la préparation du sel, et de nouvelles formes cristallines de celui-ci.</abstract><oa>free_for_read</oa></addata></record> |
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| language | eng ; fre |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | A FUMARATE SALT OF 3-BROMO-N-{ (2S) -2- (4 -FLUOROPHENYL) -4- [3- (4-ACETYLPIPERAZIN-L-YL) AZETIDIN-1-YL] BUTYL} -N-METHYL-5- (TRIFLUOROMETHYL)BENZAMIDE FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS |
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