MULTI-MODAL ABSORPTION, MEDICINE-DELIVERY LOZENGE, AND USE THEREOF
A multi-modal absorption, medicine-delivery lozenge is provided. The lozenge includes a lozenge base, a medicinal active ingredient including an antihistamine convertible between ionized and non-ionized states, and a buffer present in an effective amount for establishing an adjusted pH in a solvent...
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| creator | CHAU, TOMMY L BUCHHALTER, AUGUST R CONE, EDWARD J PINNEY, JOHN M |
| description | A multi-modal absorption, medicine-delivery lozenge is provided. The lozenge includes a lozenge base, a medicinal active ingredient including an antihistamine convertible between ionized and non-ionized states, and a buffer present in an effective amount for establishing an adjusted pH in a solvent having a pH comparable to that of saliva which is characterized by a simultaneous presence of a first pharmacologically effective dose of the non-ionized form of the medicinal active ingredient, and a second pharmacologically effective dose of the ionized form of the medicinal active ingredient.
L'invention concerne une pastille d'administration de médicament à absorption multimodale. La pastille comprend une base de pastille, un ingrédient médicamenteux actif comprenant un antihistaminique convertible entre des états ionisé et non ionisé, et un tampon présent en une quantité efficace pour établir un pH ajusté dans un solvant ayant un pH comparable à celui de la salive, qui est caractérisée par la présence simultanée d'une première dose pharmacologiquement efficace de la forme non ionisée de l'ingrédient médicamenteux actif, et une seconde dose pharmacologiquement efficace de la forme ionisée de l'ingrédient médicamenteux actif. |
| format | Patent |
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L'invention concerne une pastille d'administration de médicament à absorption multimodale. La pastille comprend une base de pastille, un ingrédient médicamenteux actif comprenant un antihistaminique convertible entre des états ionisé et non ionisé, et un tampon présent en une quantité efficace pour établir un pH ajusté dans un solvant ayant un pH comparable à celui de la salive, qui est caractérisée par la présence simultanée d'une première dose pharmacologiquement efficace de la forme non ionisée de l'ingrédient médicamenteux actif, et une seconde dose pharmacologiquement efficace de la forme ionisée de l'ingrédient médicamenteux actif.</description><language>eng ; fre</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2008</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20081002&DB=EPODOC&CC=WO&NR=2008097539A3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76292</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20081002&DB=EPODOC&CC=WO&NR=2008097539A3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CHAU, TOMMY L</creatorcontrib><creatorcontrib>BUCHHALTER, AUGUST R</creatorcontrib><creatorcontrib>CONE, EDWARD J</creatorcontrib><creatorcontrib>PINNEY, JOHN M</creatorcontrib><title>MULTI-MODAL ABSORPTION, MEDICINE-DELIVERY LOZENGE, AND USE THEREOF</title><description>A multi-modal absorption, medicine-delivery lozenge is provided. The lozenge includes a lozenge base, a medicinal active ingredient including an antihistamine convertible between ionized and non-ionized states, and a buffer present in an effective amount for establishing an adjusted pH in a solvent having a pH comparable to that of saliva which is characterized by a simultaneous presence of a first pharmacologically effective dose of the non-ionized form of the medicinal active ingredient, and a second pharmacologically effective dose of the ionized form of the medicinal active ingredient.
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L'invention concerne une pastille d'administration de médicament à absorption multimodale. La pastille comprend une base de pastille, un ingrédient médicamenteux actif comprenant un antihistaminique convertible entre des états ionisé et non ionisé, et un tampon présent en une quantité efficace pour établir un pH ajusté dans un solvant ayant un pH comparable à celui de la salive, qui est caractérisée par la présence simultanée d'une première dose pharmacologiquement efficace de la forme non ionisée de l'ingrédient médicamenteux actif, et une seconde dose pharmacologiquement efficace de la forme ionisée de l'ingrédient médicamenteux actif.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | MULTI-MODAL ABSORPTION, MEDICINE-DELIVERY LOZENGE, AND USE THEREOF |
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