N-CYCLOHEXYL BENZAMIDES AND BENZENEACETAMIDES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASES
The present invention provides N-cyclohexyl benzamide and benzeneacetamide compounds according to formula (I): where R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, m, n, p, and q are as defined in the description; as well as pharmaceutical compositions comprising the same, methods of use of...
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| creator | POWERS, JAY HAN, NIANHE LIU, QINGYIAN YUAN, CHESTER, C MCMINN, DUSTIN |
| description | The present invention provides N-cyclohexyl benzamide and benzeneacetamide compounds according to formula (I): where R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, m, n, p, and q are as defined in the description; as well as pharmaceutical compositions comprising the same, methods of use of the compounds and compositions of the invention for the treatment of conditions associated with hydroxysteroid dehydrogenases (e.g., 11ß-HSD1), and the use of the compounds of the invention in the preparation of medicaments for the treatment of hydroxysteroid dehydrogenase-associated conditions.
L'invention concerne des composés de N-cyclohexyl benzamide et de benzène acétamide selon la formule (I) où R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, m, n, p et q sont tels que définis dans la description; ainsi que des compositions pharmaceutiques les renfermant, des procédés d'utilisation des composés et des compositions de l'invention pour traiter des pathologies associées à des hydroxysteroïde déshydrogénases (p. ex. 11ß-HSD1), et l'utilisation de ces composés pour préparer des médicaments destinés au traitement de pathologies associées à des hydroxysteroïde déshydrogénases. |
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L'invention concerne des composés de N-cyclohexyl benzamide et de benzène acétamide selon la formule (I) où R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, m, n, p et q sont tels que définis dans la description; ainsi que des compositions pharmaceutiques les renfermant, des procédés d'utilisation des composés et des compositions de l'invention pour traiter des pathologies associées à des hydroxysteroïde déshydrogénases (p. ex. 11ß-HSD1), et l'utilisation de ces composés pour préparer des médicaments destinés au traitement de pathologies associées à des hydroxysteroïde déshydrogénases.</description><language>eng ; fre</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2008</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20080724&DB=EPODOC&CC=WO&NR=2008088540A2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20080724&DB=EPODOC&CC=WO&NR=2008088540A2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>POWERS, JAY</creatorcontrib><creatorcontrib>HAN, NIANHE</creatorcontrib><creatorcontrib>LIU, QINGYIAN</creatorcontrib><creatorcontrib>YUAN, CHESTER, C</creatorcontrib><creatorcontrib>MCMINN, DUSTIN</creatorcontrib><title>N-CYCLOHEXYL BENZAMIDES AND BENZENEACETAMIDES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASES</title><description>The present invention provides N-cyclohexyl benzamide and benzeneacetamide compounds according to formula (I): where R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, m, n, p, and q are as defined in the description; as well as pharmaceutical compositions comprising the same, methods of use of the compounds and compositions of the invention for the treatment of conditions associated with hydroxysteroid dehydrogenases (e.g., 11ß-HSD1), and the use of the compounds of the invention in the preparation of medicaments for the treatment of hydroxysteroid dehydrogenase-associated conditions.
L'invention concerne des composés de N-cyclohexyl benzamide et de benzène acétamide selon la formule (I) où R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, m, n, p et q sont tels que définis dans la description; ainsi que des compositions pharmaceutiques les renfermant, des procédés d'utilisation des composés et des compositions de l'invention pour traiter des pathologies associées à des hydroxysteroïde déshydrogénases (p. ex. 11ß-HSD1), et l'utilisation de ces composés pour préparer des médicaments destinés au traitement de pathologies associées à des hydroxysteroïde déshydrogénases.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2008</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNir0KwjAURrM4iPoOF5wDaVXImp9bE6gJNIE2LqVonEQL9f1Riu5Oh-98Z0mujqqkam-wSzVIdGdxshoDCKfniQ6FwvizAawzVtromwC-gqKg8vNSk3TjuxQiNt5q0DiLIzoRMKzJ4jbcp7z5ckW2FUZlaB6ffZ7G4ZIf-dW3vmSMM84PeybK3X_VGzZvNbA</recordid><startdate>20080724</startdate><enddate>20080724</enddate><creator>POWERS, JAY</creator><creator>HAN, NIANHE</creator><creator>LIU, QINGYIAN</creator><creator>YUAN, CHESTER, C</creator><creator>MCMINN, DUSTIN</creator><scope>EVB</scope></search><sort><creationdate>20080724</creationdate><title>N-CYCLOHEXYL BENZAMIDES AND BENZENEACETAMIDES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASES</title><author>POWERS, JAY ; HAN, NIANHE ; LIU, QINGYIAN ; YUAN, CHESTER, C ; MCMINN, DUSTIN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2008088540A23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2008</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>POWERS, JAY</creatorcontrib><creatorcontrib>HAN, NIANHE</creatorcontrib><creatorcontrib>LIU, QINGYIAN</creatorcontrib><creatorcontrib>YUAN, CHESTER, C</creatorcontrib><creatorcontrib>MCMINN, DUSTIN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>POWERS, JAY</au><au>HAN, NIANHE</au><au>LIU, QINGYIAN</au><au>YUAN, CHESTER, C</au><au>MCMINN, DUSTIN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>N-CYCLOHEXYL BENZAMIDES AND BENZENEACETAMIDES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASES</title><date>2008-07-24</date><risdate>2008</risdate><abstract>The present invention provides N-cyclohexyl benzamide and benzeneacetamide compounds according to formula (I): where R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, m, n, p, and q are as defined in the description; as well as pharmaceutical compositions comprising the same, methods of use of the compounds and compositions of the invention for the treatment of conditions associated with hydroxysteroid dehydrogenases (e.g., 11ß-HSD1), and the use of the compounds of the invention in the preparation of medicaments for the treatment of hydroxysteroid dehydrogenase-associated conditions.
L'invention concerne des composés de N-cyclohexyl benzamide et de benzène acétamide selon la formule (I) où R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, m, n, p et q sont tels que définis dans la description; ainsi que des compositions pharmaceutiques les renfermant, des procédés d'utilisation des composés et des compositions de l'invention pour traiter des pathologies associées à des hydroxysteroïde déshydrogénases (p. ex. 11ß-HSD1), et l'utilisation de ces composés pour préparer des médicaments destinés au traitement de pathologies associées à des hydroxysteroïde déshydrogénases.</abstract><oa>free_for_read</oa></addata></record> |
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| title | N-CYCLOHEXYL BENZAMIDES AND BENZENEACETAMIDES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASES |
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