METHODS FOR DETECTION AND MEASUREMENT OF SECRETORY PHOSPHOLIPASE A2 LEVELS (sPLA2) IN BIOLOGICAL FLUIDS
Elevated levels of secretory phospholipase A2 (sPLA2) are associated with a variety of inflammatory conditions, e.g., multiple sclerosis, arteriosclerosis, rheumatoid arthritis, osteoarthritis and sickle cell. ELISA-based assays have been developed for detecting and measuring sPLA2 levels in biologi...
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| description | Elevated levels of secretory phospholipase A2 (sPLA2) are associated with a variety of inflammatory conditions, e.g., multiple sclerosis, arteriosclerosis, rheumatoid arthritis, osteoarthritis and sickle cell. ELISA-based assays have been developed for detecting and measuring sPLA2 levels in biological fluids, but these methods are too time-consuming for practical clinical diagnostic use. Disclosed herein in certain embodiments are methods for rapid detection and measurement of sPLA2 levels (e.g., sPLA2 type IIA) in a biological fluid generally, and methods for detection and measurement of sPLA2 levels in urine.
Les taux élevés de phospholipase A2 sécrétoire (sPLA2) sont associés à une variété d'états inflammatoires, par ex., la sclérose en plaques, l'artériosclérose, l'arthrite rhumatoïde, l'ostéoarthrite et la drépanocytose. Des dosages basés sur la méthode ELISA ont été développés pour détecter et mesurer les taux de sPLA2 dans les liquides biologiques, mais ces méthodes demandent trop de temps en vue d'une utilisation pratique en diagnostic clinique. Des méthodes sont décrites dans le présent document dans certains modes de réalisation en vue de la détection et de la mesure rapides des taux de sPLA2 (par ex., sPLA2 de type IIA) dans un liquide biologique d'un point de vue général, et des méthodes de détection et de mesure des taux de sPLA2 dans l'urine. |
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Les taux élevés de phospholipase A2 sécrétoire (sPLA2) sont associés à une variété d'états inflammatoires, par ex., la sclérose en plaques, l'artériosclérose, l'arthrite rhumatoïde, l'ostéoarthrite et la drépanocytose. Des dosages basés sur la méthode ELISA ont été développés pour détecter et mesurer les taux de sPLA2 dans les liquides biologiques, mais ces méthodes demandent trop de temps en vue d'une utilisation pratique en diagnostic clinique. Des méthodes sont décrites dans le présent document dans certains modes de réalisation en vue de la détection et de la mesure rapides des taux de sPLA2 (par ex., sPLA2 de type IIA) dans un liquide biologique d'un point de vue général, et des méthodes de détection et de mesure des taux de sPLA2 dans l'urine.</description><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS OR TEST PAPERS THEREFOR ; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ; ENZYMOLOGY ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS ; METALLURGY ; MICROBIOLOGY ; MUTATION OR GENETIC ENGINEERING ; PHYSICS ; PROCESSES OF PREPARING SUCH COMPOSITIONS ; SPIRITS ; TESTING ; VINEGAR ; WINE</subject><creationdate>2008</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20080814&DB=EPODOC&CC=WO&NR=2008076994A3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20080814&DB=EPODOC&CC=WO&NR=2008076994A3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>TRUEX, PAUL</creatorcontrib><creatorcontrib>TRIAS, JOAQUIM</creatorcontrib><title>METHODS FOR DETECTION AND MEASUREMENT OF SECRETORY PHOSPHOLIPASE A2 LEVELS (sPLA2) IN BIOLOGICAL FLUIDS</title><description>Elevated levels of secretory phospholipase A2 (sPLA2) are associated with a variety of inflammatory conditions, e.g., multiple sclerosis, arteriosclerosis, rheumatoid arthritis, osteoarthritis and sickle cell. ELISA-based assays have been developed for detecting and measuring sPLA2 levels in biological fluids, but these methods are too time-consuming for practical clinical diagnostic use. Disclosed herein in certain embodiments are methods for rapid detection and measurement of sPLA2 levels (e.g., sPLA2 type IIA) in a biological fluid generally, and methods for detection and measurement of sPLA2 levels in urine.
Les taux élevés de phospholipase A2 sécrétoire (sPLA2) sont associés à une variété d'états inflammatoires, par ex., la sclérose en plaques, l'artériosclérose, l'arthrite rhumatoïde, l'ostéoarthrite et la drépanocytose. Des dosages basés sur la méthode ELISA ont été développés pour détecter et mesurer les taux de sPLA2 dans les liquides biologiques, mais ces méthodes demandent trop de temps en vue d'une utilisation pratique en diagnostic clinique. Des méthodes sont décrites dans le présent document dans certains modes de réalisation en vue de la détection et de la mesure rapides des taux de sPLA2 (par ex., sPLA2 de type IIA) dans un liquide biologique d'un point de vue général, et des méthodes de détection et de mesure des taux de sPLA2 dans l'urine.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS OR TEST PAPERS THEREFOR</subject><subject>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</subject><subject>ENZYMOLOGY</subject><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>MEASURING</subject><subject>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PHYSICS</subject><subject>PROCESSES OF PREPARING SUCH COMPOSITIONS</subject><subject>SPIRITS</subject><subject>TESTING</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2008</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNyrEKwjAQgOEuDqK-w4GLDkJppdrxTC42kOZKkipOpUh0ES3U90cHH8Dh51v-aXKvKVQsPSh2ICmQCJotoJVQE_rWUU02ACvwJBwFdhdoKvbfjG7QE2AGhk5kPKzGxmC2Bm3hoNnwUQs0oEyrpZ8nk1v_GOPi5yxZKgqi2sTh1cVx6K_xGd_dmbM03ae7oiy3mOf_XR-vADYn</recordid><startdate>20080814</startdate><enddate>20080814</enddate><creator>TRUEX, PAUL</creator><creator>TRIAS, JOAQUIM</creator><scope>EVB</scope></search><sort><creationdate>20080814</creationdate><title>METHODS FOR DETECTION AND MEASUREMENT OF SECRETORY PHOSPHOLIPASE A2 LEVELS (sPLA2) IN BIOLOGICAL FLUIDS</title><author>TRUEX, PAUL ; TRIAS, JOAQUIM</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2008076994A33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2008</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS OR TEST PAPERS THEREFOR</topic><topic>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</topic><topic>ENZYMOLOGY</topic><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>MEASURING</topic><topic>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PHYSICS</topic><topic>PROCESSES OF PREPARING SUCH COMPOSITIONS</topic><topic>SPIRITS</topic><topic>TESTING</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>TRUEX, PAUL</creatorcontrib><creatorcontrib>TRIAS, JOAQUIM</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>TRUEX, PAUL</au><au>TRIAS, JOAQUIM</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>METHODS FOR DETECTION AND MEASUREMENT OF SECRETORY PHOSPHOLIPASE A2 LEVELS (sPLA2) IN BIOLOGICAL FLUIDS</title><date>2008-08-14</date><risdate>2008</risdate><abstract>Elevated levels of secretory phospholipase A2 (sPLA2) are associated with a variety of inflammatory conditions, e.g., multiple sclerosis, arteriosclerosis, rheumatoid arthritis, osteoarthritis and sickle cell. ELISA-based assays have been developed for detecting and measuring sPLA2 levels in biological fluids, but these methods are too time-consuming for practical clinical diagnostic use. Disclosed herein in certain embodiments are methods for rapid detection and measurement of sPLA2 levels (e.g., sPLA2 type IIA) in a biological fluid generally, and methods for detection and measurement of sPLA2 levels in urine.
Les taux élevés de phospholipase A2 sécrétoire (sPLA2) sont associés à une variété d'états inflammatoires, par ex., la sclérose en plaques, l'artériosclérose, l'arthrite rhumatoïde, l'ostéoarthrite et la drépanocytose. Des dosages basés sur la méthode ELISA ont été développés pour détecter et mesurer les taux de sPLA2 dans les liquides biologiques, mais ces méthodes demandent trop de temps en vue d'une utilisation pratique en diagnostic clinique. Des méthodes sont décrites dans le présent document dans certains modes de réalisation en vue de la détection et de la mesure rapides des taux de sPLA2 (par ex., sPLA2 de type IIA) dans un liquide biologique d'un point de vue général, et des méthodes de détection et de mesure des taux de sPLA2 dans l'urine.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS TESTING VINEGAR WINE |
| title | METHODS FOR DETECTION AND MEASUREMENT OF SECRETORY PHOSPHOLIPASE A2 LEVELS (sPLA2) IN BIOLOGICAL FLUIDS |
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