CRYSTALLINE FORM OF MOXIFLOXACIN HYDROCHLORIDE
The present invention refers to a new stable crystalline form of moxifloxacin hydrochloride, to a process of its preparation and to its use in the preparation of pharmaceutical compositions. It is provided a process comprising to dissolve crude moxifloxacin hydrochloride in a mixture of methanol/wat...
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| creator | PALOMO NICOLAU, FRANCISCO VILLASANTE PRIETO, JAVIER |
| description | The present invention refers to a new stable crystalline form of moxifloxacin hydrochloride, to a process of its preparation and to its use in the preparation of pharmaceutical compositions. It is provided a process comprising to dissolve crude moxifloxacin hydrochloride in a mixture of methanol/water by heating at the reflux temperature; to add acetone and to heat the dissolution at a temperature comprised between 40 and 45°C; to cool until a temperature comprised between 15 and 25°C; to separate the crystals formed by filtration; to wash and dry the obtained product until a constant weight is obtained.
La présente invention concerne une nouvelle forme cristalline stable d'hydrochlorure de moxifloxacine, un procédé permettant de la préparer et son utilisation dans la préparation de compositions pharmaceutiques. Est proposé un procédé comprenant les opérations consistant à : dissoudre de l'hydrochlorure de moxifloxacine brut dans un mélange de méthanol/eau par chauffage à la température de reflux; ajouter de l'acétone et chauffer le produit de dissolution à une température comprise entre 40 et 45 °C; refroidir jusqu'à une température comprise entre 15 et 25 °C; séparer les cristaux formés par filtration; et laver et sécher le produit obtenu jusqu'à ce qu'un poids constant soit obtenu. |
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La présente invention concerne une nouvelle forme cristalline stable d'hydrochlorure de moxifloxacine, un procédé permettant de la préparer et son utilisation dans la préparation de compositions pharmaceutiques. Est proposé un procédé comprenant les opérations consistant à : dissoudre de l'hydrochlorure de moxifloxacine brut dans un mélange de méthanol/eau par chauffage à la température de reflux; ajouter de l'acétone et chauffer le produit de dissolution à une température comprise entre 40 et 45 °C; refroidir jusqu'à une température comprise entre 15 et 25 °C; séparer les cristaux formés par filtration; et laver et sécher le produit obtenu jusqu'à ce qu'un poids constant soit obtenu.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2008</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20080313&DB=EPODOC&CC=WO&NR=2008028959A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76419</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20080313&DB=EPODOC&CC=WO&NR=2008028959A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>PALOMO NICOLAU, FRANCISCO</creatorcontrib><creatorcontrib>VILLASANTE PRIETO, JAVIER</creatorcontrib><title>CRYSTALLINE FORM OF MOXIFLOXACIN HYDROCHLORIDE</title><description>The present invention refers to a new stable crystalline form of moxifloxacin hydrochloride, to a process of its preparation and to its use in the preparation of pharmaceutical compositions. It is provided a process comprising to dissolve crude moxifloxacin hydrochloride in a mixture of methanol/water by heating at the reflux temperature; to add acetone and to heat the dissolution at a temperature comprised between 40 and 45°C; to cool until a temperature comprised between 15 and 25°C; to separate the crystals formed by filtration; to wash and dry the obtained product until a constant weight is obtained.
La présente invention concerne une nouvelle forme cristalline stable d'hydrochlorure de moxifloxacine, un procédé permettant de la préparer et son utilisation dans la préparation de compositions pharmaceutiques. Est proposé un procédé comprenant les opérations consistant à : dissoudre de l'hydrochlorure de moxifloxacine brut dans un mélange de méthanol/eau par chauffage à la température de reflux; ajouter de l'acétone et chauffer le produit de dissolution à une température comprise entre 40 et 45 °C; refroidir jusqu'à une température comprise entre 15 et 25 °C; séparer les cristaux formés par filtration; et laver et sécher le produit obtenu jusqu'à ce qu'un poids constant soit obtenu.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2008</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNBzDooMDnH08fH0c1Vw8w_yVfB3U_D1j_B08_GPcHT29FPwiHQJ8nf28PEP8nRx5WFgTUvMKU7lhdLcDMpuriHOHrqpBfnxqcUFicmpeakl8eH-RgYGFgZGFpamlo6GxsSpAgCgjicP</recordid><startdate>20080313</startdate><enddate>20080313</enddate><creator>PALOMO NICOLAU, FRANCISCO</creator><creator>VILLASANTE PRIETO, JAVIER</creator><scope>EVB</scope></search><sort><creationdate>20080313</creationdate><title>CRYSTALLINE FORM OF MOXIFLOXACIN HYDROCHLORIDE</title><author>PALOMO NICOLAU, FRANCISCO ; VILLASANTE PRIETO, JAVIER</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2008028959A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2008</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>PALOMO NICOLAU, FRANCISCO</creatorcontrib><creatorcontrib>VILLASANTE PRIETO, JAVIER</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>PALOMO NICOLAU, FRANCISCO</au><au>VILLASANTE PRIETO, JAVIER</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>CRYSTALLINE FORM OF MOXIFLOXACIN HYDROCHLORIDE</title><date>2008-03-13</date><risdate>2008</risdate><abstract>The present invention refers to a new stable crystalline form of moxifloxacin hydrochloride, to a process of its preparation and to its use in the preparation of pharmaceutical compositions. It is provided a process comprising to dissolve crude moxifloxacin hydrochloride in a mixture of methanol/water by heating at the reflux temperature; to add acetone and to heat the dissolution at a temperature comprised between 40 and 45°C; to cool until a temperature comprised between 15 and 25°C; to separate the crystals formed by filtration; to wash and dry the obtained product until a constant weight is obtained.
La présente invention concerne une nouvelle forme cristalline stable d'hydrochlorure de moxifloxacine, un procédé permettant de la préparer et son utilisation dans la préparation de compositions pharmaceutiques. Est proposé un procédé comprenant les opérations consistant à : dissoudre de l'hydrochlorure de moxifloxacine brut dans un mélange de méthanol/eau par chauffage à la température de reflux; ajouter de l'acétone et chauffer le produit de dissolution à une température comprise entre 40 et 45 °C; refroidir jusqu'à une température comprise entre 15 et 25 °C; séparer les cristaux formés par filtration; et laver et sécher le produit obtenu jusqu'à ce qu'un poids constant soit obtenu.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | CRYSTALLINE FORM OF MOXIFLOXACIN HYDROCHLORIDE |
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