NAPHTHOFURANONE DERIVATIVES AS SPECIFIC INHIBITORS OF THYMIDYLATE SYNTHASES

Synthetic compounds of 1, 2 -naphthalein molecules (I) having specific inhibitory properties of the enzymatic activity of thymidylate synthases of bacterial species, their preparation, their pharmaceutical composition and use in the treatment and prophylaxis of infectious pathologies are disclosed....

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Bibliographische Detailangaben
Hauptverfasser:	TONDI, DONATELLA, ROSSI, TIZIANA, COSTI, MARIA, PAOLA, BARLOCCO, DANIELA, VENTURELLI, ALBERTO, PECORARI, PIERGIORGIO, CASOLARI, CHIARA
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Synthetic compounds of 1, 2 -naphthalein molecules (I) having specific inhibitory properties of the enzymatic activity of thymidylate synthases of bacterial species, their preparation, their pharmaceutical composition and use in the treatment and prophylaxis of infectious pathologies are disclosed. L'invention concerne des composés synthétiques de molécules de 1,2 -naphtaléine (I) ayant des propriétés inhibitrices spécifiques de l'activité enzymatique des synthases de thymidylate d'espèces bactériennes, leur préparation, leur composition pharmaceutique et leur utilisation dans le traitement et la prophylaxie de pathologies infectieuses.