SUBSTITUTED ARYLPYRAZOLOPYRIDINES AND SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, METHODS OF PREPARING SAME AND USES OF SAME
The invention relates to substituted arylpyrazolopyridines according to the general formula (I) : in which A, B, D, E, Ra, R1, R2, R3, R4, R5 and q are as defined in the claims, and salts thereof, to pharmaceutical compositions comprising said substituted arylpyrazolopyridines, to methods of prepari...
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| creator | LIENAU, PHILIP THIERAUCH, KARL-HEINZ INCE, STUART HARTUNG, INGO KETTSCHAU, GEORG BRIEM, HANS TER LAAK, ANTONIUS, M |
| description | The invention relates to substituted arylpyrazolopyridines according to the general formula (I) : in which A, B, D, E, Ra, R1, R2, R3, R4, R5 and q are as defined in the claims, and salts thereof, to pharmaceutical compositions comprising said substituted arylpyrazolopyridines, to methods of preparing said substituted arylpyrazolopyridines as well as the use thereof for manufacturing a pharmaceutical composition for the treatment of diseases of dysregulated vascular growth or of diseases which are accompanied with dysregulated vascular growth, wherein the compounds effectively interfere with Tie2 signalling.
La présente invention concerne des arylpyrazolopyridines substituées de formule générale (I) : où A, B, D, E, Ra, R1, R2, R3, R4, R5 et q sont tels que définis dans les revendications, ainsi que leurs sels, les compositions pharmaceutiques comprenant lesdites arylpyrazolopyridines substituées, les méthodes de synthèses desdites arylpyrazolopyridines substituées et leur emploi dans la fabrication d'une composition pharmaceutique destinée au traitement de maladies impliquant un dérèglement de la croissance vasculaire ou de maladies accompagnées d'un dérèglement de la croissance vasculaire, les composés interférant de façon active avec la signalisation par Tie2. |
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La présente invention concerne des arylpyrazolopyridines substituées de formule générale (I) : où A, B, D, E, Ra, R1, R2, R3, R4, R5 et q sont tels que définis dans les revendications, ainsi que leurs sels, les compositions pharmaceutiques comprenant lesdites arylpyrazolopyridines substituées, les méthodes de synthèses desdites arylpyrazolopyridines substituées et leur emploi dans la fabrication d'une composition pharmaceutique destinée au traitement de maladies impliquant un dérèglement de la croissance vasculaire ou de maladies accompagnées d'un dérèglement de la croissance vasculaire, les composés interférant de façon active avec la signalisation par Tie2.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2007</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20071221&DB=EPODOC&CC=WO&NR=2007144203A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20071221&DB=EPODOC&CC=WO&NR=2007144203A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LIENAU, PHILIP</creatorcontrib><creatorcontrib>THIERAUCH, KARL-HEINZ</creatorcontrib><creatorcontrib>INCE, STUART</creatorcontrib><creatorcontrib>HARTUNG, INGO</creatorcontrib><creatorcontrib>KETTSCHAU, GEORG</creatorcontrib><creatorcontrib>BRIEM, HANS</creatorcontrib><creatorcontrib>TER LAAK, ANTONIUS, M</creatorcontrib><title>SUBSTITUTED ARYLPYRAZOLOPYRIDINES AND SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, METHODS OF PREPARING SAME AND USES OF SAME</title><description>The invention relates to substituted arylpyrazolopyridines according to the general formula (I) : in which A, B, D, E, Ra, R1, R2, R3, R4, R5 and q are as defined in the claims, and salts thereof, to pharmaceutical compositions comprising said substituted arylpyrazolopyridines, to methods of preparing said substituted arylpyrazolopyridines as well as the use thereof for manufacturing a pharmaceutical composition for the treatment of diseases of dysregulated vascular growth or of diseases which are accompanied with dysregulated vascular growth, wherein the compounds effectively interfere with Tie2 signalling.
La présente invention concerne des arylpyrazolopyridines substituées de formule générale (I) : où A, B, D, E, Ra, R1, R2, R3, R4, R5 et q sont tels que définis dans les revendications, ainsi que leurs sels, les compositions pharmaceutiques comprenant lesdites arylpyrazolopyridines substituées, les méthodes de synthèses desdites arylpyrazolopyridines substituées et leur emploi dans la fabrication d'une composition pharmaceutique destinée au traitement de maladies impliquant un dérèglement de la croissance vasculaire ou de maladies accompagnées d'un dérèglement de la croissance vasculaire, les composés interférant de façon active avec la signalisation par Tie2.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2007</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjEELglAQhL10iOo_LHQ1sBQ6b7rmA3Ufb1fCLhLxOkUF9jP60ZnUvdMw883MNHhJsxM12ihlgK4tbevwyCUPajJTkwDWGQiWKqAFOeI8BFugqzClRk2KJaRcWRajhmsZjTNi6v2wqiiEirTgTIBzsI4suh8anxuhEX2CeTC5nK69X3x1Fixz0rRY-ce98_3jdPY3_-wOvImi7TpJNlGM6_i_1hvz3UDv</recordid><startdate>20071221</startdate><enddate>20071221</enddate><creator>LIENAU, PHILIP</creator><creator>THIERAUCH, KARL-HEINZ</creator><creator>INCE, STUART</creator><creator>HARTUNG, INGO</creator><creator>KETTSCHAU, GEORG</creator><creator>BRIEM, HANS</creator><creator>TER LAAK, ANTONIUS, M</creator><scope>EVB</scope></search><sort><creationdate>20071221</creationdate><title>SUBSTITUTED ARYLPYRAZOLOPYRIDINES AND SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, METHODS OF PREPARING SAME AND USES OF SAME</title><author>LIENAU, PHILIP ; THIERAUCH, KARL-HEINZ ; INCE, STUART ; HARTUNG, INGO ; KETTSCHAU, GEORG ; BRIEM, HANS ; TER LAAK, ANTONIUS, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2007144203A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2007</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>LIENAU, PHILIP</creatorcontrib><creatorcontrib>THIERAUCH, KARL-HEINZ</creatorcontrib><creatorcontrib>INCE, STUART</creatorcontrib><creatorcontrib>HARTUNG, INGO</creatorcontrib><creatorcontrib>KETTSCHAU, GEORG</creatorcontrib><creatorcontrib>BRIEM, HANS</creatorcontrib><creatorcontrib>TER LAAK, ANTONIUS, M</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LIENAU, PHILIP</au><au>THIERAUCH, KARL-HEINZ</au><au>INCE, STUART</au><au>HARTUNG, INGO</au><au>KETTSCHAU, GEORG</au><au>BRIEM, HANS</au><au>TER LAAK, ANTONIUS, M</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>SUBSTITUTED ARYLPYRAZOLOPYRIDINES AND SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, METHODS OF PREPARING SAME AND USES OF SAME</title><date>2007-12-21</date><risdate>2007</risdate><abstract>The invention relates to substituted arylpyrazolopyridines according to the general formula (I) : in which A, B, D, E, Ra, R1, R2, R3, R4, R5 and q are as defined in the claims, and salts thereof, to pharmaceutical compositions comprising said substituted arylpyrazolopyridines, to methods of preparing said substituted arylpyrazolopyridines as well as the use thereof for manufacturing a pharmaceutical composition for the treatment of diseases of dysregulated vascular growth or of diseases which are accompanied with dysregulated vascular growth, wherein the compounds effectively interfere with Tie2 signalling.
La présente invention concerne des arylpyrazolopyridines substituées de formule générale (I) : où A, B, D, E, Ra, R1, R2, R3, R4, R5 et q sont tels que définis dans les revendications, ainsi que leurs sels, les compositions pharmaceutiques comprenant lesdites arylpyrazolopyridines substituées, les méthodes de synthèses desdites arylpyrazolopyridines substituées et leur emploi dans la fabrication d'une composition pharmaceutique destinée au traitement de maladies impliquant un dérèglement de la croissance vasculaire ou de maladies accompagnées d'un dérèglement de la croissance vasculaire, les composés interférant de façon active avec la signalisation par Tie2.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | SUBSTITUTED ARYLPYRAZOLOPYRIDINES AND SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, METHODS OF PREPARING SAME AND USES OF SAME |
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