GPCR LIGANDS IDENTIFIED BY COMPUTATIONAL MODELING

Disclosed are pharmacophores for developing and screening compounds having G-protein-coupled receptor antagonist activity, including LPA1, LPA2, LPA3 and S1P antagonists. These compositions have therapeutic benefit in the fields of cancer chemotherapy, cardiovascular disease prevention, and protecti...

Ausführliche Beschreibung

Bibliographische Detailangaben

Hauptverfasser:	TIGYI, GABOR, PARRILL, ABBY, FELLS, JAMES, PERYGIN, DONNA
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CALCULATING CHEMISTRY COMPUTING COUNTING ELECTRIC DIGITAL DATA PROCESSING HETEROCYCLIC COMPOUNDS INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING METALLURGY ORGANIC CHEMISTRY PHYSICS TESTING
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