PROCESS FOR THE PREPARATION OF 6-(4-CHLOROPHENYL)-2,2-DIMETHYL-7-PHENYL-2, 3-DIHYDRO-1H-PYRROLIZIN-5-YL ACETIC ACID AND ITS INTERMEDIATES
The present invention relates to a process for the preparation of 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2, 3-dihydro-1H-pyrrolizin-5-yl acetic acid, in which the key intermediate, 5-Benzyl-3,3-dimethyl-3,4-dihydro-2H-pyrrole is obtained by the hydrogenation of 2,2-dimethyl-4-oxo-5-phenyl-nitropen...
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| creator | BHIMA, KALE, Y AMIT, C., KHANDEKAR RAMAKRISHNAN, ARUL |
| description | The present invention relates to a process for the preparation of 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2, 3-dihydro-1H-pyrrolizin-5-yl acetic acid, in which the key intermediate, 5-Benzyl-3,3-dimethyl-3,4-dihydro-2H-pyrrole is obtained by the hydrogenation of 2,2-dimethyl-4-oxo-5-phenyl-nitropentane. The invention also relates to the preparation of the intermediates occurring in the above process.
La présente invention concerne un procédé de synthèse de l'acide 6-(4-chlorophényl)-2,2-diméthyl-7-phényl-2,3-dihydro-1H-pyrrolizin-5-ylacétique dans lequel l'intermédiaire clé, le 5-benzyl-3,3-diméthyl-3,4-dihydro-2H-pyrrole, est obtenu par hydrogénation du 2,2-diméthyl-4-oxo-5-phényl-nitropentane. La présente invention concerne également la synthèse des intermédiaires apparaissant dans le procédé ci-dessus. |
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La présente invention concerne un procédé de synthèse de l'acide 6-(4-chlorophényl)-2,2-diméthyl-7-phényl-2,3-dihydro-1H-pyrrolizin-5-ylacétique dans lequel l'intermédiaire clé, le 5-benzyl-3,3-diméthyl-3,4-dihydro-2H-pyrrole, est obtenu par hydrogénation du 2,2-diméthyl-4-oxo-5-phényl-nitropentane. La présente invention concerne également la synthèse des intermédiaires apparaissant dans le procédé ci-dessus.</description><language>eng ; fre</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2007</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20070927&DB=EPODOC&CC=WO&NR=2007108006A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20070927&DB=EPODOC&CC=WO&NR=2007108006A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>BHIMA, KALE, Y</creatorcontrib><creatorcontrib>AMIT, C., KHANDEKAR</creatorcontrib><creatorcontrib>RAMAKRISHNAN, ARUL</creatorcontrib><title>PROCESS FOR THE PREPARATION OF 6-(4-CHLOROPHENYL)-2,2-DIMETHYL-7-PHENYL-2, 3-DIHYDRO-1H-PYRROLIZIN-5-YL ACETIC ACID AND ITS INTERMEDIATES</title><description>The present invention relates to a process for the preparation of 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2, 3-dihydro-1H-pyrrolizin-5-yl acetic acid, in which the key intermediate, 5-Benzyl-3,3-dimethyl-3,4-dihydro-2H-pyrrole is obtained by the hydrogenation of 2,2-dimethyl-4-oxo-5-phenyl-nitropentane. The invention also relates to the preparation of the intermediates occurring in the above process.
La présente invention concerne un procédé de synthèse de l'acide 6-(4-chlorophényl)-2,2-diméthyl-7-phényl-2,3-dihydro-1H-pyrrolizin-5-ylacétique dans lequel l'intermédiaire clé, le 5-benzyl-3,3-diméthyl-3,4-dihydro-2H-pyrrole, est obtenu par hydrogénation du 2,2-diméthyl-4-oxo-5-phényl-nitropentane. La présente invention concerne également la synthèse des intermédiaires apparaissant dans le procédé ci-dessus.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2007</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNys9KAzEQgPG9eJDqOwx4qeBAdvv3GpJZMpBmwmxA0kspJZ5EC_UlfGsX9AE8ffDju---s4qjaYJRFEogyErZqi0sCWSELS7X6EIUlRwo1fiMw8uAng9UQo24w1-eFVYzh-pVsA-Yq6pEPnLCDdYI1lFhN4c92OSBywScCumBPNtC00N393Z-v7XHvy66p5GKC9iun6d2u54v7aN9nV5lMGbXm70xW9uv_nf9ALwvPjo</recordid><startdate>20070927</startdate><enddate>20070927</enddate><creator>BHIMA, KALE, Y</creator><creator>AMIT, C., KHANDEKAR</creator><creator>RAMAKRISHNAN, ARUL</creator><scope>EVB</scope></search><sort><creationdate>20070927</creationdate><title>PROCESS FOR THE PREPARATION OF 6-(4-CHLOROPHENYL)-2,2-DIMETHYL-7-PHENYL-2, 3-DIHYDRO-1H-PYRROLIZIN-5-YL ACETIC ACID AND ITS INTERMEDIATES</title><author>BHIMA, KALE, Y ; AMIT, C., KHANDEKAR ; RAMAKRISHNAN, ARUL</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2007108006A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2007</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>BHIMA, KALE, Y</creatorcontrib><creatorcontrib>AMIT, C., KHANDEKAR</creatorcontrib><creatorcontrib>RAMAKRISHNAN, ARUL</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>BHIMA, KALE, Y</au><au>AMIT, C., KHANDEKAR</au><au>RAMAKRISHNAN, ARUL</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PROCESS FOR THE PREPARATION OF 6-(4-CHLOROPHENYL)-2,2-DIMETHYL-7-PHENYL-2, 3-DIHYDRO-1H-PYRROLIZIN-5-YL ACETIC ACID AND ITS INTERMEDIATES</title><date>2007-09-27</date><risdate>2007</risdate><abstract>The present invention relates to a process for the preparation of 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2, 3-dihydro-1H-pyrrolizin-5-yl acetic acid, in which the key intermediate, 5-Benzyl-3,3-dimethyl-3,4-dihydro-2H-pyrrole is obtained by the hydrogenation of 2,2-dimethyl-4-oxo-5-phenyl-nitropentane. The invention also relates to the preparation of the intermediates occurring in the above process.
La présente invention concerne un procédé de synthèse de l'acide 6-(4-chlorophényl)-2,2-diméthyl-7-phényl-2,3-dihydro-1H-pyrrolizin-5-ylacétique dans lequel l'intermédiaire clé, le 5-benzyl-3,3-diméthyl-3,4-dihydro-2H-pyrrole, est obtenu par hydrogénation du 2,2-diméthyl-4-oxo-5-phényl-nitropentane. La présente invention concerne également la synthèse des intermédiaires apparaissant dans le procédé ci-dessus.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY |
| title | PROCESS FOR THE PREPARATION OF 6-(4-CHLOROPHENYL)-2,2-DIMETHYL-7-PHENYL-2, 3-DIHYDRO-1H-PYRROLIZIN-5-YL ACETIC ACID AND ITS INTERMEDIATES |
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