CATHEPSIN PROPEPTIDE AND USES THEREOF

A method of inhibiting activity of a cathepsin L-like protease in cells or tissue and the use of the method in the treatment of disease such as cancer and inflammatory diseases is described. The method comprises administration of a cathepsin propeptide or a nucleic acid encoding a cathepsin propepti...

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Hauptverfasser: SNODDY, PHILIP, SCOTT, CHRISTOPHER, BUICK, RICHARD, MCCURLEY, MARK, JOHNSTON, JIM, BURDEN, ROBERTA
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creator SNODDY, PHILIP
SCOTT, CHRISTOPHER
BUICK, RICHARD
MCCURLEY, MARK
JOHNSTON, JIM
BURDEN, ROBERTA
description A method of inhibiting activity of a cathepsin L-like protease in cells or tissue and the use of the method in the treatment of disease such as cancer and inflammatory diseases is described. The method comprises administration of a cathepsin propeptide or a nucleic acid encoding a cathepsin propeptide. In particular embodiments, the propeptide is a Cathepsin S propeptide. Further, the use of propeptides having an Fc portion is described. La présente invention concerne un procédé permettant d'inhiber l'activité d'une protéase semblable à la cathepsine L dans des cellules ou un tissu, ainsi que l'utilisation du procédé dans le cadre du traitement de maladies telles que le cancer et les maladies inflammatoires. Le procédé ci-décrit consiste à administrer un propeptide de cathepsine ou un acide nucléique codant pour un propeptide de cathepsine. Dans des modes de réalisation particuliers, le propeptide est un propeptide de la cathepsine S. La présente invention concerne en outre l'utilisation de propeptides comprenant une partie Fc.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title CATHEPSIN PROPEPTIDE AND USES THEREOF
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