METHOD OF DETECTING AZT RESISTANCE IN HIV
Described herein is a method of determining the presence of a nucleoside reverse transcriptase inhibitor-resistant Human Immunodeficiency Virus- 1 (HIV-I) virus particle in a biological sample, comprising identifying the presence in the sample of a point mutation at codon Q509 of an HIV-I reverse tr...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Format: | Patent |
| Sprache: | eng ; fre |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | MELLORS, JOHN, W KOONTZ, DIANNA BREHM, JESSICA, H |
| description | Described herein is a method of determining the presence of a nucleoside reverse transcriptase inhibitor-resistant Human Immunodeficiency Virus- 1 (HIV-I) virus particle in a biological sample, comprising identifying the presence in the sample of a point mutation at codon Q509 of an HIV-I reverse transcriptase, for example and without limitation Q509L. That point mutation increases resistance to AZT about 3- to 10-fold by itself and about 50-fold in combination with the connection domain mutation A371 V.
L'invention concerne une méthode permettant de détecter la présence dans un échantillon biologique d'une particule du virus de l'immunodéficience humaine -1 (VIH-1) résistant à un inhibiteur de transcriptase inverse nucléosidique. Cette méthode consiste à identifier la présence dans l'échantillon d'un point de mutation au niveau du codon Q509 d'une transcriptase inverse du VIH-1, par exemple et sans limitation, au niveau du codon Q509L. Ce point de mutation accroît à lui seul la résistance à l'AZT de 3 à 10 fois environ et que quelque 50 fois en combinaison avec la mutation du domaine de connexion A371V. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_WO2007089692A2</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>WO2007089692A2</sourcerecordid><originalsourceid>FETCH-epo_espacenet_WO2007089692A23</originalsourceid><addsrcrecordid>eNrjZND0dQ3x8HdR8HdTcHENcXUO8fRzV3CMClEIcg32DA5x9HN2VfD0U_DwDONhYE1LzClO5YXS3AzKbq4hzh66qQX58anFBYnJqXmpJfHh_kYGBuYGFpZmlkaORsbEqQIApSUlIw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>METHOD OF DETECTING AZT RESISTANCE IN HIV</title><source>esp@cenet</source><creator>MELLORS, JOHN, W ; KOONTZ, DIANNA ; BREHM, JESSICA, H</creator><creatorcontrib>MELLORS, JOHN, W ; KOONTZ, DIANNA ; BREHM, JESSICA, H</creatorcontrib><description>Described herein is a method of determining the presence of a nucleoside reverse transcriptase inhibitor-resistant Human Immunodeficiency Virus- 1 (HIV-I) virus particle in a biological sample, comprising identifying the presence in the sample of a point mutation at codon Q509 of an HIV-I reverse transcriptase, for example and without limitation Q509L. That point mutation increases resistance to AZT about 3- to 10-fold by itself and about 50-fold in combination with the connection domain mutation A371 V.
L'invention concerne une méthode permettant de détecter la présence dans un échantillon biologique d'une particule du virus de l'immunodéficience humaine -1 (VIH-1) résistant à un inhibiteur de transcriptase inverse nucléosidique. Cette méthode consiste à identifier la présence dans l'échantillon d'un point de mutation au niveau du codon Q509 d'une transcriptase inverse du VIH-1, par exemple et sans limitation, au niveau du codon Q509L. Ce point de mutation accroît à lui seul la résistance à l'AZT de 3 à 10 fois environ et que quelque 50 fois en combinaison avec la mutation du domaine de connexion A371V.</description><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS OR TEST PAPERS THEREFOR ; COMPOSITIONS THEREOF ; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ; CULTURE MEDIA ; ENZYMOLOGY ; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE ; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PROCESSES OF PREPARING SUCH COMPOSITIONS ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2007</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20070809&DB=EPODOC&CC=WO&NR=2007089692A2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20070809&DB=EPODOC&CC=WO&NR=2007089692A2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MELLORS, JOHN, W</creatorcontrib><creatorcontrib>KOONTZ, DIANNA</creatorcontrib><creatorcontrib>BREHM, JESSICA, H</creatorcontrib><title>METHOD OF DETECTING AZT RESISTANCE IN HIV</title><description>Described herein is a method of determining the presence of a nucleoside reverse transcriptase inhibitor-resistant Human Immunodeficiency Virus- 1 (HIV-I) virus particle in a biological sample, comprising identifying the presence in the sample of a point mutation at codon Q509 of an HIV-I reverse transcriptase, for example and without limitation Q509L. That point mutation increases resistance to AZT about 3- to 10-fold by itself and about 50-fold in combination with the connection domain mutation A371 V.
L'invention concerne une méthode permettant de détecter la présence dans un échantillon biologique d'une particule du virus de l'immunodéficience humaine -1 (VIH-1) résistant à un inhibiteur de transcriptase inverse nucléosidique. Cette méthode consiste à identifier la présence dans l'échantillon d'un point de mutation au niveau du codon Q509 d'une transcriptase inverse du VIH-1, par exemple et sans limitation, au niveau du codon Q509L. Ce point de mutation accroît à lui seul la résistance à l'AZT de 3 à 10 fois environ et que quelque 50 fois en combinaison avec la mutation du domaine de connexion A371V.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS OR TEST PAPERS THEREFOR</subject><subject>COMPOSITIONS THEREOF</subject><subject>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</subject><subject>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PROCESSES OF PREPARING SUCH COMPOSITIONS</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2007</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZND0dQ3x8HdR8HdTcHENcXUO8fRzV3CMClEIcg32DA5x9HN2VfD0U_DwDONhYE1LzClO5YXS3AzKbq4hzh66qQX58anFBYnJqXmpJfHh_kYGBuYGFpZmlkaORsbEqQIApSUlIw</recordid><startdate>20070809</startdate><enddate>20070809</enddate><creator>MELLORS, JOHN, W</creator><creator>KOONTZ, DIANNA</creator><creator>BREHM, JESSICA, H</creator><scope>EVB</scope></search><sort><creationdate>20070809</creationdate><title>METHOD OF DETECTING AZT RESISTANCE IN HIV</title><author>MELLORS, JOHN, W ; KOONTZ, DIANNA ; BREHM, JESSICA, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2007089692A23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2007</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS OR TEST PAPERS THEREFOR</topic><topic>COMPOSITIONS THEREOF</topic><topic>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</topic><topic>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PROCESSES OF PREPARING SUCH COMPOSITIONS</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>MELLORS, JOHN, W</creatorcontrib><creatorcontrib>KOONTZ, DIANNA</creatorcontrib><creatorcontrib>BREHM, JESSICA, H</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>MELLORS, JOHN, W</au><au>KOONTZ, DIANNA</au><au>BREHM, JESSICA, H</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>METHOD OF DETECTING AZT RESISTANCE IN HIV</title><date>2007-08-09</date><risdate>2007</risdate><abstract>Described herein is a method of determining the presence of a nucleoside reverse transcriptase inhibitor-resistant Human Immunodeficiency Virus- 1 (HIV-I) virus particle in a biological sample, comprising identifying the presence in the sample of a point mutation at codon Q509 of an HIV-I reverse transcriptase, for example and without limitation Q509L. That point mutation increases resistance to AZT about 3- to 10-fold by itself and about 50-fold in combination with the connection domain mutation A371 V.
L'invention concerne une méthode permettant de détecter la présence dans un échantillon biologique d'une particule du virus de l'immunodéficience humaine -1 (VIH-1) résistant à un inhibiteur de transcriptase inverse nucléosidique. Cette méthode consiste à identifier la présence dans l'échantillon d'un point de mutation au niveau du codon Q509 d'une transcriptase inverse du VIH-1, par exemple et sans limitation, au niveau du codon Q509L. Ce point de mutation accroît à lui seul la résistance à l'AZT de 3 à 10 fois environ et que quelque 50 fois en combinaison avec la mutation du domaine de connexion A371V.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng ; fre |
| recordid | cdi_epo_espacenet_WO2007089692A2 |
| source | esp@cenet |
| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| title | METHOD OF DETECTING AZT RESISTANCE IN HIV |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T06%3A33%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=MELLORS,%20JOHN,%20W&rft.date=2007-08-09&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EWO2007089692A2%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |