METHOD OF DRUG DESIGN
The invention provides a method of identifying biologically active compounds comprising: (a) designing a first library of compounds of formula (1) to scan molecular diversity wherein each compound of the library has at least two pharmacophoric groups R1 to R5 as defined below and wherein compound of...
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| creator | MEUTERMANS, WIM ZUEGG, JOHANNES TOMETZKI, GERALD, B |
| description | The invention provides a method of identifying biologically active compounds comprising: (a) designing a first library of compounds of formula (1) to scan molecular diversity wherein each compound of the library has at least two pharmacophoric groups R1 to R5 as defined below and wherein compound of the library has same number of pharmacophoric groups; (b) assaying the first library of compounds in one or more biological assay(s); and (c) designing a second library wherein each compound of the second library contains one or more additional pharmacophoric group with respect to the first library; such that the/each component of the first and second library is a compound of formula (1).
La présente invention concerne une méthode d'identification de composés biologiquement actifs qui comprend : (a) la conception d'une première bibliothèque de composés de formule (1) pour balayer la diversité moléculaire, chaque composé de la bibliothèque portant au moins deux groupements pharmacophores R1 à R5 comme défini ci-dessous, et chaque composé de la bibliothèque ayant le même nombre de groupements pharmacophores ; (b) l'évaluation de la première bibliothèque de composés dans un ou plusieurs tests biologiques ; et (c) la conception d'une seconde bibliothèque, chaque composé de la seconde bibliothèque contenant un ou plusieurs groupements pharmacophores supplémentaires par rapport à la première bibliothèque ; de sorte que le/chaque composant de la première et de la seconde bibliothèque soit un composé de formule (1). |
| format | Patent |
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La présente invention concerne une méthode d'identification de composés biologiquement actifs qui comprend : (a) la conception d'une première bibliothèque de composés de formule (1) pour balayer la diversité moléculaire, chaque composé de la bibliothèque portant au moins deux groupements pharmacophores R1 à R5 comme défini ci-dessous, et chaque composé de la bibliothèque ayant le même nombre de groupements pharmacophores ; (b) l'évaluation de la première bibliothèque de composés dans un ou plusieurs tests biologiques ; et (c) la conception d'une seconde bibliothèque, chaque composé de la seconde bibliothèque contenant un ou plusieurs groupements pharmacophores supplémentaires par rapport à la première bibliothèque ; de sorte que le/chaque composant de la première et de la seconde bibliothèque soit un composé de formule (1).</description><language>eng ; fre</language><subject>APPARATUS THEREFOR ; CHEMISTRY ; COMBINATORIAL CHEMISTRY ; DERIVATIVES THEREOF ; GENERAL METHODS OF ORGANIC CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES ; MEASURING ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; NUCLEIC ACIDS ; NUCLEOSIDES ; NUCLEOTIDES ; ORGANIC CHEMISTRY ; PEPTIDES ; PHYSICS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SUGARS ; TESTING</subject><creationdate>2008</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20080327&DB=EPODOC&CC=WO&NR=2007038829A8$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20080327&DB=EPODOC&CC=WO&NR=2007038829A8$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MEUTERMANS, WIM</creatorcontrib><creatorcontrib>ZUEGG, JOHANNES</creatorcontrib><creatorcontrib>TOMETZKI, GERALD, B</creatorcontrib><title>METHOD OF DRUG DESIGN</title><description>The invention provides a method of identifying biologically active compounds comprising: (a) designing a first library of compounds of formula (1) to scan molecular diversity wherein each compound of the library has at least two pharmacophoric groups R1 to R5 as defined below and wherein compound of the library has same number of pharmacophoric groups; (b) assaying the first library of compounds in one or more biological assay(s); and (c) designing a second library wherein each compound of the second library contains one or more additional pharmacophoric group with respect to the first library; such that the/each component of the first and second library is a compound of formula (1).
La présente invention concerne une méthode d'identification de composés biologiquement actifs qui comprend : (a) la conception d'une première bibliothèque de composés de formule (1) pour balayer la diversité moléculaire, chaque composé de la bibliothèque portant au moins deux groupements pharmacophores R1 à R5 comme défini ci-dessous, et chaque composé de la bibliothèque ayant le même nombre de groupements pharmacophores ; (b) l'évaluation de la première bibliothèque de composés dans un ou plusieurs tests biologiques ; et (c) la conception d'une seconde bibliothèque, chaque composé de la seconde bibliothèque contenant un ou plusieurs groupements pharmacophores supplémentaires par rapport à la première bibliothèque ; de sorte que le/chaque composant de la première et de la seconde bibliothèque soit un composé de formule (1).</description><subject>APPARATUS THEREFOR</subject><subject>CHEMISTRY</subject><subject>COMBINATORIAL CHEMISTRY</subject><subject>DERIVATIVES THEREOF</subject><subject>GENERAL METHODS OF ORGANIC CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES</subject><subject>MEASURING</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>NUCLEIC ACIDS</subject><subject>NUCLEOSIDES</subject><subject>NUCLEOTIDES</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PHYSICS</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SUGARS</subject><subject>TESTING</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2008</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZBD1dQ3x8HdR8HdTcAkKdVdwcQ32dPfjYWBNS8wpTuWF0twMym6uIc4euqkF-fGpxQWJyal5qSXx4f5GBgbmBsYWFkaWjhbGxKkCAPv5H6o</recordid><startdate>20080327</startdate><enddate>20080327</enddate><creator>MEUTERMANS, WIM</creator><creator>ZUEGG, JOHANNES</creator><creator>TOMETZKI, GERALD, B</creator><scope>EVB</scope></search><sort><creationdate>20080327</creationdate><title>METHOD OF DRUG DESIGN</title><author>MEUTERMANS, WIM ; ZUEGG, JOHANNES ; TOMETZKI, GERALD, B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2007038829A83</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2008</creationdate><topic>APPARATUS THEREFOR</topic><topic>CHEMISTRY</topic><topic>COMBINATORIAL CHEMISTRY</topic><topic>DERIVATIVES THEREOF</topic><topic>GENERAL METHODS OF ORGANIC CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES</topic><topic>MEASURING</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>NUCLEIC ACIDS</topic><topic>NUCLEOSIDES</topic><topic>NUCLEOTIDES</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PHYSICS</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SUGARS</topic><topic>TESTING</topic><toplevel>online_resources</toplevel><creatorcontrib>MEUTERMANS, WIM</creatorcontrib><creatorcontrib>ZUEGG, JOHANNES</creatorcontrib><creatorcontrib>TOMETZKI, GERALD, B</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>MEUTERMANS, WIM</au><au>ZUEGG, JOHANNES</au><au>TOMETZKI, GERALD, B</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>METHOD OF DRUG DESIGN</title><date>2008-03-27</date><risdate>2008</risdate><abstract>The invention provides a method of identifying biologically active compounds comprising: (a) designing a first library of compounds of formula (1) to scan molecular diversity wherein each compound of the library has at least two pharmacophoric groups R1 to R5 as defined below and wherein compound of the library has same number of pharmacophoric groups; (b) assaying the first library of compounds in one or more biological assay(s); and (c) designing a second library wherein each compound of the second library contains one or more additional pharmacophoric group with respect to the first library; such that the/each component of the first and second library is a compound of formula (1).
La présente invention concerne une méthode d'identification de composés biologiquement actifs qui comprend : (a) la conception d'une première bibliothèque de composés de formule (1) pour balayer la diversité moléculaire, chaque composé de la bibliothèque portant au moins deux groupements pharmacophores R1 à R5 comme défini ci-dessous, et chaque composé de la bibliothèque ayant le même nombre de groupements pharmacophores ; (b) l'évaluation de la première bibliothèque de composés dans un ou plusieurs tests biologiques ; et (c) la conception d'une seconde bibliothèque, chaque composé de la seconde bibliothèque contenant un ou plusieurs groupements pharmacophores supplémentaires par rapport à la première bibliothèque ; de sorte que le/chaque composant de la première et de la seconde bibliothèque soit un composé de formule (1).</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | APPARATUS THEREFOR CHEMISTRY COMBINATORIAL CHEMISTRY DERIVATIVES THEREOF GENERAL METHODS OF ORGANIC CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS TESTING |
| title | METHOD OF DRUG DESIGN |
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