A PROCESS FOR PREPARING (2R,3S)-1,2-EPOXY-3-(PROTECTED)AMINO-4-SUBSTITUTED BUTANE AND INTERMEDIATES THEREOF
The present invention relates to a process for preparing (2R,3S)-1-halo-2-hydroxy-3-(protected)amino-4-substituted butane comprising contacting a mutagenized Rhodococcus erythropolis having ATCC deposit no. PTA-6648 with (3S)-1-halo-2-oxo-3-(protected)amino-4-substituted butane substrate. The presen...
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| creator | CHIANG, SHU-JEN STEIN, GREGORY, L YOU, LI ANDERSON, WENDY, L XING, ZIZHUO BOWERS, NIGEL, IAN FRANCESCHINI, THOMAS SKONEZNY, PAUL, M |
| description | The present invention relates to a process for preparing (2R,3S)-1-halo-2-hydroxy-3-(protected)amino-4-substituted butane comprising contacting a mutagenized Rhodococcus erythropolis having ATCC deposit no. PTA-6648 with (3S)-1-halo-2-oxo-3-(protected)amino-4-substituted butane substrate. The present invention also relates to a process comprising mixing (2R,3S)-1-halo-2-hydroxy-3-(protected)amino-4-substituted butane with at least one base in the presence of at least one solvent to produce a reaction mixture containing (2R,3S)-1,2-epoxy-3-(protected)amino-4-substituted butane. The present invention further relates to a process comprising crystallizing the (2R,3S)-1,2-epoxy-3-(protected)amino-4-substituted butane out of the reaction mixture by concurrently adding water and the reaction mixture together. The present invention is also directed to a mutagenized Rhodococcus erythropolis having ATCC deposit no. PTA-6648.
La présente invention concerne un procédé pour préparer du butane (2R,3S)-1-halo-2-hydroxy-3-(protégé)amino-4-substitué, comprenant la mise en contact d'un Rhodococcus erythropolis mutagénisé ayant un dépôt ATCC no. PTA-6648 avec un substrat de butane (3S)-1-halo-2-oxo-3-(protégé)amino-4-substituté. L'invention a également pour objet un procédé comprenant le mélange de butane (2R,3S)-1-halo-2-hydroxy-3-(protégé)amino-4-substituté avec au moins une base, en la présence d'au moins un solvant, pour produire un mélange réactionnel contenant du butane (2R,3S)-1,2-époxy-3-(protégé)amino-4-substituté. L'invention concerne aussi un procédé comprenant la cristallisation du butane (2R,3S)-1,2-époxy-3-(protégé)amino-4-substituté, hors du mélange réactionnel, par adjonction simultanée d'eau et du mélange réactionnel. L'invention se rapporte également à un Rhodococcus erythropolis mutagénisé ayant un dépôt ATCC no. PTA-6648. |
| format | Patent |
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La présente invention concerne un procédé pour préparer du butane (2R,3S)-1-halo-2-hydroxy-3-(protégé)amino-4-substitué, comprenant la mise en contact d'un Rhodococcus erythropolis mutagénisé ayant un dépôt ATCC no. PTA-6648 avec un substrat de butane (3S)-1-halo-2-oxo-3-(protégé)amino-4-substituté. L'invention a également pour objet un procédé comprenant le mélange de butane (2R,3S)-1-halo-2-hydroxy-3-(protégé)amino-4-substituté avec au moins une base, en la présence d'au moins un solvant, pour produire un mélange réactionnel contenant du butane (2R,3S)-1,2-époxy-3-(protégé)amino-4-substituté. L'invention concerne aussi un procédé comprenant la cristallisation du butane (2R,3S)-1,2-époxy-3-(protégé)amino-4-substituté, hors du mélange réactionnel, par adjonction simultanée d'eau et du mélange réactionnel. L'invention se rapporte également à un Rhodococcus erythropolis mutagénisé ayant un dépôt ATCC no. PTA-6648.</description><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; ENZYMOLOGY ; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE ; METALLURGY ; MICROBIOLOGY ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2006</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20061130&DB=EPODOC&CC=WO&NR=2006127180A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25555,76308</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20061130&DB=EPODOC&CC=WO&NR=2006127180A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CHIANG, SHU-JEN</creatorcontrib><creatorcontrib>STEIN, GREGORY, L</creatorcontrib><creatorcontrib>YOU, LI</creatorcontrib><creatorcontrib>ANDERSON, WENDY, L</creatorcontrib><creatorcontrib>XING, ZIZHUO</creatorcontrib><creatorcontrib>BOWERS, NIGEL, IAN</creatorcontrib><creatorcontrib>FRANCESCHINI, THOMAS</creatorcontrib><creatorcontrib>SKONEZNY, PAUL, M</creatorcontrib><title>A PROCESS FOR PREPARING (2R,3S)-1,2-EPOXY-3-(PROTECTED)AMINO-4-SUBSTITUTED BUTANE AND INTERMEDIATES THEREOF</title><description>The present invention relates to a process for preparing (2R,3S)-1-halo-2-hydroxy-3-(protected)amino-4-substituted butane comprising contacting a mutagenized Rhodococcus erythropolis having ATCC deposit no. PTA-6648 with (3S)-1-halo-2-oxo-3-(protected)amino-4-substituted butane substrate. The present invention also relates to a process comprising mixing (2R,3S)-1-halo-2-hydroxy-3-(protected)amino-4-substituted butane with at least one base in the presence of at least one solvent to produce a reaction mixture containing (2R,3S)-1,2-epoxy-3-(protected)amino-4-substituted butane. The present invention further relates to a process comprising crystallizing the (2R,3S)-1,2-epoxy-3-(protected)amino-4-substituted butane out of the reaction mixture by concurrently adding water and the reaction mixture together. The present invention is also directed to a mutagenized Rhodococcus erythropolis having ATCC deposit no. PTA-6648.
La présente invention concerne un procédé pour préparer du butane (2R,3S)-1-halo-2-hydroxy-3-(protégé)amino-4-substitué, comprenant la mise en contact d'un Rhodococcus erythropolis mutagénisé ayant un dépôt ATCC no. PTA-6648 avec un substrat de butane (3S)-1-halo-2-oxo-3-(protégé)amino-4-substituté. L'invention a également pour objet un procédé comprenant le mélange de butane (2R,3S)-1-halo-2-hydroxy-3-(protégé)amino-4-substituté avec au moins une base, en la présence d'au moins un solvant, pour produire un mélange réactionnel contenant du butane (2R,3S)-1,2-époxy-3-(protégé)amino-4-substituté. L'invention concerne aussi un procédé comprenant la cristallisation du butane (2R,3S)-1,2-époxy-3-(protégé)amino-4-substituté, hors du mélange réactionnel, par adjonction simultanée d'eau et du mélange réactionnel. L'invention se rapporte également à un Rhodococcus erythropolis mutagénisé ayant un dépôt ATCC no. PTA-6648.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>ENZYMOLOGY</subject><subject>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2006</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNirEKwjAUALs4iPoPD1xaaKBJRV3T9tVmaBKSV9SpFImLooX6_9jBD3C647hl9JBgnSnRe6iNmx2tdEqfIBYuzX3CeCoYWnO5spzF80pYElaJbJU2bMd8V3hS1M0Nio6kRpC6AqUJXYuVkoQeqEGHpl5Hi_vwnMLmx1W0rZHKhoXx3YdpHG7hFT792Ygs23Nx4MdM8vy_6wsJjTaD</recordid><startdate>20061130</startdate><enddate>20061130</enddate><creator>CHIANG, SHU-JEN</creator><creator>STEIN, GREGORY, L</creator><creator>YOU, LI</creator><creator>ANDERSON, WENDY, L</creator><creator>XING, ZIZHUO</creator><creator>BOWERS, NIGEL, IAN</creator><creator>FRANCESCHINI, THOMAS</creator><creator>SKONEZNY, PAUL, M</creator><scope>EVB</scope></search><sort><creationdate>20061130</creationdate><title>A PROCESS FOR PREPARING (2R,3S)-1,2-EPOXY-3-(PROTECTED)AMINO-4-SUBSTITUTED BUTANE AND INTERMEDIATES THEREOF</title><author>CHIANG, SHU-JEN ; STEIN, GREGORY, L ; YOU, LI ; ANDERSON, WENDY, L ; XING, ZIZHUO ; BOWERS, NIGEL, IAN ; FRANCESCHINI, THOMAS ; SKONEZNY, PAUL, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2006127180A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2006</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>ENZYMOLOGY</topic><topic>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>CHIANG, SHU-JEN</creatorcontrib><creatorcontrib>STEIN, GREGORY, L</creatorcontrib><creatorcontrib>YOU, LI</creatorcontrib><creatorcontrib>ANDERSON, WENDY, L</creatorcontrib><creatorcontrib>XING, ZIZHUO</creatorcontrib><creatorcontrib>BOWERS, NIGEL, IAN</creatorcontrib><creatorcontrib>FRANCESCHINI, THOMAS</creatorcontrib><creatorcontrib>SKONEZNY, PAUL, M</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>CHIANG, SHU-JEN</au><au>STEIN, GREGORY, L</au><au>YOU, LI</au><au>ANDERSON, WENDY, L</au><au>XING, ZIZHUO</au><au>BOWERS, NIGEL, IAN</au><au>FRANCESCHINI, THOMAS</au><au>SKONEZNY, PAUL, M</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>A PROCESS FOR PREPARING (2R,3S)-1,2-EPOXY-3-(PROTECTED)AMINO-4-SUBSTITUTED BUTANE AND INTERMEDIATES THEREOF</title><date>2006-11-30</date><risdate>2006</risdate><abstract>The present invention relates to a process for preparing (2R,3S)-1-halo-2-hydroxy-3-(protected)amino-4-substituted butane comprising contacting a mutagenized Rhodococcus erythropolis having ATCC deposit no. PTA-6648 with (3S)-1-halo-2-oxo-3-(protected)amino-4-substituted butane substrate. The present invention also relates to a process comprising mixing (2R,3S)-1-halo-2-hydroxy-3-(protected)amino-4-substituted butane with at least one base in the presence of at least one solvent to produce a reaction mixture containing (2R,3S)-1,2-epoxy-3-(protected)amino-4-substituted butane. The present invention further relates to a process comprising crystallizing the (2R,3S)-1,2-epoxy-3-(protected)amino-4-substituted butane out of the reaction mixture by concurrently adding water and the reaction mixture together. The present invention is also directed to a mutagenized Rhodococcus erythropolis having ATCC deposit no. PTA-6648.
La présente invention concerne un procédé pour préparer du butane (2R,3S)-1-halo-2-hydroxy-3-(protégé)amino-4-substitué, comprenant la mise en contact d'un Rhodococcus erythropolis mutagénisé ayant un dépôt ATCC no. PTA-6648 avec un substrat de butane (3S)-1-halo-2-oxo-3-(protégé)amino-4-substituté. L'invention a également pour objet un procédé comprenant le mélange de butane (2R,3S)-1-halo-2-hydroxy-3-(protégé)amino-4-substituté avec au moins une base, en la présence d'au moins un solvant, pour produire un mélange réactionnel contenant du butane (2R,3S)-1,2-époxy-3-(protégé)amino-4-substituté. L'invention concerne aussi un procédé comprenant la cristallisation du butane (2R,3S)-1,2-époxy-3-(protégé)amino-4-substituté, hors du mélange réactionnel, par adjonction simultanée d'eau et du mélange réactionnel. L'invention se rapporte également à un Rhodococcus erythropolis mutagénisé ayant un dépôt ATCC no. PTA-6648.</abstract><oa>free_for_read</oa></addata></record> |
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| title | A PROCESS FOR PREPARING (2R,3S)-1,2-EPOXY-3-(PROTECTED)AMINO-4-SUBSTITUTED BUTANE AND INTERMEDIATES THEREOF |
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