STABILIZED ANTI-HEPATITIS B (HBV) ANTIBODY FORMULATIONS
The present invention provides liquid formulations of antibodies or fragments thereof that specifically bind to a hepatitis B virus (HBV) antigen, which formulations exhibit stability, low to undetectable levels of aggregations, and very little to no loss of the biological activities of the antibodi...
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| creator | O'CONNOR, SANDRA DAGAN, SHLOMO EREN, RACHEL GOWAN, WALTER, G., JR MISRA, HEMANT, KUMAR |
| description | The present invention provides liquid formulations of antibodies or fragments thereof that specifically bind to a hepatitis B virus (HBV) antigen, which formulations exhibit stability, low to undetectable levels of aggregations, and very little to no loss of the biological activities of the antibodies or antibody fragments, even during long periods of storage. Furthermore, the invention provides methods of preventing, treating or ameliorating one or more symptoms associated with HBV infection utilizing the liquid formulations of the present invention.
L'invention concerne des préparations liquides d'anticorps ou de fragments d'anticorps qui se lient spécifiquement avec l'antigène du virus de l'hépatite B (VHB). Cette préparation est stable, présente des niveaux faibles à indétectables d'agrégation, et une perte très faible voire inexistante de l'activité biologique des anticorps ou des fragments d'anticorps, même en cas de stockage prolongé. L'invention concerne en outre des méthodes de prévention, de traitement ou d'amélioration d'un ou de plusieurs symptômes associés à une infection VHB, comprenant l'administration des préparations liquides décrites. |
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L'invention concerne des préparations liquides d'anticorps ou de fragments d'anticorps qui se lient spécifiquement avec l'antigène du virus de l'hépatite B (VHB). Cette préparation est stable, présente des niveaux faibles à indétectables d'agrégation, et une perte très faible voire inexistante de l'activité biologique des anticorps ou des fragments d'anticorps, même en cas de stockage prolongé. L'invention concerne en outre des méthodes de prévention, de traitement ou d'amélioration d'un ou de plusieurs symptômes associés à une infection VHB, comprenant l'administration des préparations liquides décrites.</description><language>eng ; fre</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2006</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20061026&DB=EPODOC&CC=WO&NR=2006112838A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76318</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20061026&DB=EPODOC&CC=WO&NR=2006112838A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>O'CONNOR, SANDRA</creatorcontrib><creatorcontrib>DAGAN, SHLOMO</creatorcontrib><creatorcontrib>EREN, RACHEL</creatorcontrib><creatorcontrib>GOWAN, WALTER, G., JR</creatorcontrib><creatorcontrib>MISRA, HEMANT, KUMAR</creatorcontrib><title>STABILIZED ANTI-HEPATITIS B (HBV) ANTIBODY FORMULATIONS</title><description>The present invention provides liquid formulations of antibodies or fragments thereof that specifically bind to a hepatitis B virus (HBV) antigen, which formulations exhibit stability, low to undetectable levels of aggregations, and very little to no loss of the biological activities of the antibodies or antibody fragments, even during long periods of storage. Furthermore, the invention provides methods of preventing, treating or ameliorating one or more symptoms associated with HBV infection utilizing the liquid formulations of the present invention.
L'invention concerne des préparations liquides d'anticorps ou de fragments d'anticorps qui se lient spécifiquement avec l'antigène du virus de l'hépatite B (VHB). Cette préparation est stable, présente des niveaux faibles à indétectables d'agrégation, et une perte très faible voire inexistante de l'activité biologique des anticorps ou des fragments d'anticorps, même en cas de stockage prolongé. L'invention concerne en outre des méthodes de prévention, de traitement ou d'amélioration d'un ou de plusieurs symptômes associés à une infection VHB, comprenant l'administration des préparations liquides décrites.</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2006</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDAPDnF08vTxjHJ1UXD0C_HU9XANcAzxDPEMVnBS0PBwCtMECzv5u0QquPkH-Yb6AGX9_YJ5GFjTEnOKU3mhNDeDsptriLOHbmpBfnxqcUFicmpeakl8uL-RgYGZoaGRhbGFo6ExcaoA0RIpCw</recordid><startdate>20061026</startdate><enddate>20061026</enddate><creator>O'CONNOR, SANDRA</creator><creator>DAGAN, SHLOMO</creator><creator>EREN, RACHEL</creator><creator>GOWAN, WALTER, G., JR</creator><creator>MISRA, HEMANT, KUMAR</creator><scope>EVB</scope></search><sort><creationdate>20061026</creationdate><title>STABILIZED ANTI-HEPATITIS B (HBV) ANTIBODY FORMULATIONS</title><author>O'CONNOR, SANDRA ; DAGAN, SHLOMO ; EREN, RACHEL ; GOWAN, WALTER, G., JR ; MISRA, HEMANT, KUMAR</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2006112838A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2006</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>O'CONNOR, SANDRA</creatorcontrib><creatorcontrib>DAGAN, SHLOMO</creatorcontrib><creatorcontrib>EREN, RACHEL</creatorcontrib><creatorcontrib>GOWAN, WALTER, G., JR</creatorcontrib><creatorcontrib>MISRA, HEMANT, KUMAR</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>O'CONNOR, SANDRA</au><au>DAGAN, SHLOMO</au><au>EREN, RACHEL</au><au>GOWAN, WALTER, G., JR</au><au>MISRA, HEMANT, KUMAR</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>STABILIZED ANTI-HEPATITIS B (HBV) ANTIBODY FORMULATIONS</title><date>2006-10-26</date><risdate>2006</risdate><abstract>The present invention provides liquid formulations of antibodies or fragments thereof that specifically bind to a hepatitis B virus (HBV) antigen, which formulations exhibit stability, low to undetectable levels of aggregations, and very little to no loss of the biological activities of the antibodies or antibody fragments, even during long periods of storage. Furthermore, the invention provides methods of preventing, treating or ameliorating one or more symptoms associated with HBV infection utilizing the liquid formulations of the present invention.
L'invention concerne des préparations liquides d'anticorps ou de fragments d'anticorps qui se lient spécifiquement avec l'antigène du virus de l'hépatite B (VHB). Cette préparation est stable, présente des niveaux faibles à indétectables d'agrégation, et une perte très faible voire inexistante de l'activité biologique des anticorps ou des fragments d'anticorps, même en cas de stockage prolongé. L'invention concerne en outre des méthodes de prévention, de traitement ou d'amélioration d'un ou de plusieurs symptômes associés à une infection VHB, comprenant l'administration des préparations liquides décrites.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | STABILIZED ANTI-HEPATITIS B (HBV) ANTIBODY FORMULATIONS |
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