4-PIPERAZINYLTHIENO [2, 3-D] PYRIMIDINE COMPOUNDS AS PLATELET AGGREGATION INHIBITORS

4-PIPERAZINYLTHIENO [2, 3-D] PYRIMIDINE COMPOUNDS AS PLATELET AGGREGATION INHIBITORS

Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula (I) wherein A1, A2, A3, A4, A5, A6, A7, A8, X4, X6, R2k, R2l, R4, R5, and R6 are as defined in the detailed description of the invention. Corresponding pharmaceutical c...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: ENNIS, MICHAEL, DALTON, KORTUM, STEVEN, WADE, TENBRINK, RUTH, ELIZABETH
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula (I) wherein A1, A2, A3, A4, A5, A6, A7, A8, X4, X6, R2k, R2l, R4, R5, and R6 are as defined in the detailed description of the invention. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed. L'invention concerne des composés et des sels pharmaceutiquement tolérables desdits composés. Lesdits composés présentent la structure de formule (I), dans laquelle A1, A2, A3, A4, A5, A6, A7, A8, X4, X6, R2k, R2l, R4, R5 et R6 figurent comme définis dans la description détaillée de l'invention. L'invention concerne des compositions pharmaceutiques correspondantes, des procédés de traitement, des procédés de synthèse, ainsi que des produits intermédiaires.