PREPARATION OF AUTOLOGOUS HAEMATOPOIETIC STEM CELLS, THE METHODS OF PRODUCTION, CYROPRESERVATION AND USE FOR THERAPY OF TRAUMATIC DISEASES OF THE CENTRAL NERVOUS SYSTEM
The invention applies to the field of cell transplantology and neurology and can be used to treat wound dystrophy of the central nervous system. The main idea of the invention is a preparation of haematopoietic stem cells (HSC), which is autologous HSC extracted from patient's peripheral blood...
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| creator | MKHEIDZE, DEIMURI MELITONOVICH PALUMBO, OLGA MENTEKEVICH, GEORGIY LUDOMIROVICH BRYUKHOVETSKIY, ANDREI STEPANOVICH YARYGIN, VLADIMIR NIKITICH ZAITSEV, ANDREI YURYEVICH |
| description | The invention applies to the field of cell transplantology and neurology and can be used to treat wound dystrophy of the central nervous system. The main idea of the invention is a preparation of haematopoietic stem cells (HSC), which is autologous HSC extracted from patient's peripheral blood enriched with cells containing CD34 antigen, in the final concentration of (40-100)x106 cells/ml. Enriching the blood is performed using intermittent administration of the preparation of the granulocyte colony-stimulating factor (G-CSF) - for example, Neilogen in the glucose solution, according to a certain scheme. Also, the method of production, cryoconservation of the preparation and the method of treating traumatic diseases in the brain and spinal cord, using the new preparation. The developed system allows patients to be helped with neurological diseases efficiently and suffering minimum injuries.
L'invention se rapporte au domaine de la transplantologie et de la neurologie cellulaires, et peut servir à traiter une dystrophie du système nerveux central liée à une plaie. Cette invention concerne principalement une préparation de cellules souches hématopoïétiques (HSC) de type autologues qui sont extraites du sang périphérique d'un patient, enrichi de cellules contenant l'antigène CD34 à une concentration finale de (40-100)x106 cellules/ml. L'enrichissement du sang se fait par administration intermittente d'une préparation du facteur stimulant les colonies de granulocytes (G-CSF), par exemple le produit Neupogen dans une solution de glucose, selon un schéma donné. Cette invention concerne également un procédé de production et de cryoconservation de ladite préparation, et un procédé pour traiter des maladies traumatiques affectant le cerveau et la moelle épinière, au moyen de cette préparation. L'invention permet d'aider des patients présentant des maladies neurologiques, d'une manière efficace et de façon à entraîner le moins de lésions possible. |
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L'invention se rapporte au domaine de la transplantologie et de la neurologie cellulaires, et peut servir à traiter une dystrophie du système nerveux central liée à une plaie. Cette invention concerne principalement une préparation de cellules souches hématopoïétiques (HSC) de type autologues qui sont extraites du sang périphérique d'un patient, enrichi de cellules contenant l'antigène CD34 à une concentration finale de (40-100)x106 cellules/ml. L'enrichissement du sang se fait par administration intermittente d'une préparation du facteur stimulant les colonies de granulocytes (G-CSF), par exemple le produit Neupogen dans une solution de glucose, selon un schéma donné. Cette invention concerne également un procédé de production et de cryoconservation de ladite préparation, et un procédé pour traiter des maladies traumatiques affectant le cerveau et la moelle épinière, au moyen de cette préparation. L'invention permet d'aider des patients présentant des maladies neurologiques, d'une manière efficace et de façon à entraîner le moins de lésions possible.</description><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2006</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20061005&DB=EPODOC&CC=WO&NR=2006102933A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,782,887,25571,76555</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20061005&DB=EPODOC&CC=WO&NR=2006102933A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MKHEIDZE, DEIMURI MELITONOVICH</creatorcontrib><creatorcontrib>PALUMBO, OLGA</creatorcontrib><creatorcontrib>MENTEKEVICH, GEORGIY LUDOMIROVICH</creatorcontrib><creatorcontrib>BRYUKHOVETSKIY, ANDREI STEPANOVICH</creatorcontrib><creatorcontrib>YARYGIN, VLADIMIR NIKITICH</creatorcontrib><creatorcontrib>ZAITSEV, ANDREI YURYEVICH</creatorcontrib><title>PREPARATION OF AUTOLOGOUS HAEMATOPOIETIC STEM CELLS, THE METHODS OF PRODUCTION, CYROPRESERVATION AND USE FOR THERAPY OF TRAUMATIC DISEASES OF THE CENTRAL NERVOUS SYSTEM</title><description>The invention applies to the field of cell transplantology and neurology and can be used to treat wound dystrophy of the central nervous system. The main idea of the invention is a preparation of haematopoietic stem cells (HSC), which is autologous HSC extracted from patient's peripheral blood enriched with cells containing CD34 antigen, in the final concentration of (40-100)x106 cells/ml. Enriching the blood is performed using intermittent administration of the preparation of the granulocyte colony-stimulating factor (G-CSF) - for example, Neilogen in the glucose solution, according to a certain scheme. Also, the method of production, cryoconservation of the preparation and the method of treating traumatic diseases in the brain and spinal cord, using the new preparation. The developed system allows patients to be helped with neurological diseases efficiently and suffering minimum injuries.
L'invention se rapporte au domaine de la transplantologie et de la neurologie cellulaires, et peut servir à traiter une dystrophie du système nerveux central liée à une plaie. Cette invention concerne principalement une préparation de cellules souches hématopoïétiques (HSC) de type autologues qui sont extraites du sang périphérique d'un patient, enrichi de cellules contenant l'antigène CD34 à une concentration finale de (40-100)x106 cellules/ml. L'enrichissement du sang se fait par administration intermittente d'une préparation du facteur stimulant les colonies de granulocytes (G-CSF), par exemple le produit Neupogen dans une solution de glucose, selon un schéma donné. Cette invention concerne également un procédé de production et de cryoconservation de ladite préparation, et un procédé pour traiter des maladies traumatiques affectant le cerveau et la moelle épinière, au moyen de cette préparation. L'invention permet d'aider des patients présentant des maladies neurologiques, d'une manière efficace et de façon à entraîner le moins de lésions possible.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2006</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNzsGKwkAMBuBePCy67xDwqlAtLHgM09QW2maYZJSeish4EhX0oXxMZ9QH2FMOf_4v-cme1pFFh9pwD1wBeuWWt-wFaqQOlS03pI0BUerAUNvKArQm6EhrLiWVrOPSm0QswAyOoynkdh8U-xK8EFTsUs-hHVJHHfrIR7hshFDoLSXYUB_DFvpIpD9kSKdn2eR0ON_D73dOs3lFaupluF3HcL8djuESHuOe13n-t8rXm6LAVfG_rRcpvUiJ</recordid><startdate>20061005</startdate><enddate>20061005</enddate><creator>MKHEIDZE, DEIMURI MELITONOVICH</creator><creator>PALUMBO, OLGA</creator><creator>MENTEKEVICH, GEORGIY LUDOMIROVICH</creator><creator>BRYUKHOVETSKIY, ANDREI STEPANOVICH</creator><creator>YARYGIN, VLADIMIR NIKITICH</creator><creator>ZAITSEV, ANDREI YURYEVICH</creator><scope>EVB</scope></search><sort><creationdate>20061005</creationdate><title>PREPARATION OF AUTOLOGOUS HAEMATOPOIETIC STEM CELLS, THE METHODS OF PRODUCTION, CYROPRESERVATION AND USE FOR THERAPY OF TRAUMATIC DISEASES OF THE CENTRAL NERVOUS SYSTEM</title><author>MKHEIDZE, DEIMURI MELITONOVICH ; PALUMBO, OLGA ; MENTEKEVICH, GEORGIY LUDOMIROVICH ; BRYUKHOVETSKIY, ANDREI STEPANOVICH ; YARYGIN, VLADIMIR NIKITICH ; ZAITSEV, ANDREI YURYEVICH</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2006102933A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2006</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>MKHEIDZE, DEIMURI MELITONOVICH</creatorcontrib><creatorcontrib>PALUMBO, OLGA</creatorcontrib><creatorcontrib>MENTEKEVICH, GEORGIY LUDOMIROVICH</creatorcontrib><creatorcontrib>BRYUKHOVETSKIY, ANDREI STEPANOVICH</creatorcontrib><creatorcontrib>YARYGIN, VLADIMIR NIKITICH</creatorcontrib><creatorcontrib>ZAITSEV, ANDREI YURYEVICH</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>MKHEIDZE, DEIMURI MELITONOVICH</au><au>PALUMBO, OLGA</au><au>MENTEKEVICH, GEORGIY LUDOMIROVICH</au><au>BRYUKHOVETSKIY, ANDREI STEPANOVICH</au><au>YARYGIN, VLADIMIR NIKITICH</au><au>ZAITSEV, ANDREI YURYEVICH</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PREPARATION OF AUTOLOGOUS HAEMATOPOIETIC STEM CELLS, THE METHODS OF PRODUCTION, CYROPRESERVATION AND USE FOR THERAPY OF TRAUMATIC DISEASES OF THE CENTRAL NERVOUS SYSTEM</title><date>2006-10-05</date><risdate>2006</risdate><abstract>The invention applies to the field of cell transplantology and neurology and can be used to treat wound dystrophy of the central nervous system. The main idea of the invention is a preparation of haematopoietic stem cells (HSC), which is autologous HSC extracted from patient's peripheral blood enriched with cells containing CD34 antigen, in the final concentration of (40-100)x106 cells/ml. Enriching the blood is performed using intermittent administration of the preparation of the granulocyte colony-stimulating factor (G-CSF) - for example, Neilogen in the glucose solution, according to a certain scheme. Also, the method of production, cryoconservation of the preparation and the method of treating traumatic diseases in the brain and spinal cord, using the new preparation. The developed system allows patients to be helped with neurological diseases efficiently and suffering minimum injuries.
L'invention se rapporte au domaine de la transplantologie et de la neurologie cellulaires, et peut servir à traiter une dystrophie du système nerveux central liée à une plaie. Cette invention concerne principalement une préparation de cellules souches hématopoïétiques (HSC) de type autologues qui sont extraites du sang périphérique d'un patient, enrichi de cellules contenant l'antigène CD34 à une concentration finale de (40-100)x106 cellules/ml. L'enrichissement du sang se fait par administration intermittente d'une préparation du facteur stimulant les colonies de granulocytes (G-CSF), par exemple le produit Neupogen dans une solution de glucose, selon un schéma donné. Cette invention concerne également un procédé de production et de cryoconservation de ladite préparation, et un procédé pour traiter des maladies traumatiques affectant le cerveau et la moelle épinière, au moyen de cette préparation. L'invention permet d'aider des patients présentant des maladies neurologiques, d'une manière efficace et de façon à entraîner le moins de lésions possible.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | PREPARATION OF AUTOLOGOUS HAEMATOPOIETIC STEM CELLS, THE METHODS OF PRODUCTION, CYROPRESERVATION AND USE FOR THERAPY OF TRAUMATIC DISEASES OF THE CENTRAL NERVOUS SYSTEM |
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