ALDOLASE AUTOANTIGENS USEFUL IN DIAGNOSIS AND TREATMENT OF ALZHEIMER'S DISEASE

The present invention discloses the identification of an autoantigen useful in diagnosis and treatment of Alzheimer's disease. Specifically, the present invention relates to methods and kits for diagnosing Alzheimer's disease by determining the presence of anti-aldolase antibodies in a bio...

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Bibliographische Detailangaben
Hauptverfasser:	MOR, FELIX, IZAK, MARINA, COHEN, IRUN, R
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention discloses the identification of an autoantigen useful in diagnosis and treatment of Alzheimer's disease. Specifically, the present invention relates to methods and kits for diagnosing Alzheimer's disease by determining the presence of anti-aldolase antibodies in a biological sample of a subject and to methods for treating Alzheimer's disease by modulating the immune response of the subject. La présente invention concerne l'identification d'un autoantigène utile pour diagnostiquer et traiter la maladie d'Alzheimer. L'invention concerne en particulier des méthodes et des nécessaires pour diagnostiquer la maladie d'Alzheimer par détermination de la présence d'anticorps anti-aldolase dans un échantillon biologique d'un sujet, ainsi que des méthodes de traitement de la maladie d'Alzheimer par modulation de la réponse immunitaire du sujet.