PLATELET-DERIVED MICROPARTICLES FOR THERAPY
The present invention provides methods for inducing or promoting angiogenesis in situ in which platelet derived microparticles (PMP) are administered to a target tissue or organ or in proximity with the tissue or organ. The methods of the invention may be used for treating conditions related to hypo...
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| creator | VARON, DAVID RIVO, JULIA DASHEVSKY, OLGA BRILL, ALEXANDER |
| description | The present invention provides methods for inducing or promoting angiogenesis in situ in which platelet derived microparticles (PMP) are administered to a target tissue or organ or in proximity with the tissue or organ. The methods of the invention may be used for treating conditions related to hypoxia such as ischemia. Also provided are compositions comprising as the active ingredient PMP for in situ induction or promotion of angiogenesis. A particular group of conditions to be treated by the methods and compositions of the present invention include heart diseases, specifically, cardiovascular diseases, more specifically, myocardial infarctions.
La présente invention concerne des méthodes propres à induire ou à favoriser un angiogenèse in situ, selon lesquelles on administre des microparticules d'origine plaquettaire (PMP) à un tissu ou à un organe cible, ou bien à proximité dudit tissu ou organe. Les méthodes de l'invention peuvent s'utiliser pour le traitement d'affections en rapport avec l'hypoxie tels que l'ischémie. L'invention concerne également des compositions contenant le principe actif PMP pour induction ou promotion in situ de l'angiogenèse. Un groupe particulier de pathologies à traiter au moyen des méthodes et des compositions de la présente invention est constitué par les affections cardiaques, en particulier les maladies cardio-vasculaires, et singulièrement les infarctus du myocarde. |
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La présente invention concerne des méthodes propres à induire ou à favoriser un angiogenèse in situ, selon lesquelles on administre des microparticules d'origine plaquettaire (PMP) à un tissu ou à un organe cible, ou bien à proximité dudit tissu ou organe. Les méthodes de l'invention peuvent s'utiliser pour le traitement d'affections en rapport avec l'hypoxie tels que l'ischémie. L'invention concerne également des compositions contenant le principe actif PMP pour induction ou promotion in situ de l'angiogenèse. Un groupe particulier de pathologies à traiter au moyen des méthodes et des compositions de la présente invention est constitué par les affections cardiaques, en particulier les maladies cardio-vasculaires, et singulièrement les infarctus du myocarde.</description><language>eng ; fre</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2006</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20060608&DB=EPODOC&CC=WO&NR=2006059329A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20060608&DB=EPODOC&CC=WO&NR=2006059329A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>VARON, DAVID</creatorcontrib><creatorcontrib>RIVO, JULIA</creatorcontrib><creatorcontrib>DASHEVSKY, OLGA</creatorcontrib><creatorcontrib>BRILL, ALEXANDER</creatorcontrib><title>PLATELET-DERIVED MICROPARTICLES FOR THERAPY</title><description>The present invention provides methods for inducing or promoting angiogenesis in situ in which platelet derived microparticles (PMP) are administered to a target tissue or organ or in proximity with the tissue or organ. The methods of the invention may be used for treating conditions related to hypoxia such as ischemia. Also provided are compositions comprising as the active ingredient PMP for in situ induction or promotion of angiogenesis. A particular group of conditions to be treated by the methods and compositions of the present invention include heart diseases, specifically, cardiovascular diseases, more specifically, myocardial infarctions.
La présente invention concerne des méthodes propres à induire ou à favoriser un angiogenèse in situ, selon lesquelles on administre des microparticules d'origine plaquettaire (PMP) à un tissu ou à un organe cible, ou bien à proximité dudit tissu ou organe. Les méthodes de l'invention peuvent s'utiliser pour le traitement d'affections en rapport avec l'hypoxie tels que l'ischémie. L'invention concerne également des compositions contenant le principe actif PMP pour induction ou promotion in situ de l'angiogenèse. Un groupe particulier de pathologies à traiter au moyen des méthodes et des compositions de la présente invention est constitué par les affections cardiaques, en particulier les maladies cardio-vasculaires, et singulièrement les infarctus du myocarde.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2006</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNAO8HEMcfVxDdF1cQ3yDHN1UfD1dA7yD3AMCvF09nENVnDzD1II8XANcgyI5GFgTUvMKU7lhdLcDMpuriHOHrqpBfnxqcUFicmpeakl8eH-RgYGZgamlsZGlo6GxsSpAgAjqyYa</recordid><startdate>20060608</startdate><enddate>20060608</enddate><creator>VARON, DAVID</creator><creator>RIVO, JULIA</creator><creator>DASHEVSKY, OLGA</creator><creator>BRILL, ALEXANDER</creator><scope>EVB</scope></search><sort><creationdate>20060608</creationdate><title>PLATELET-DERIVED MICROPARTICLES FOR THERAPY</title><author>VARON, DAVID ; RIVO, JULIA ; DASHEVSKY, OLGA ; BRILL, ALEXANDER</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2006059329A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2006</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>VARON, DAVID</creatorcontrib><creatorcontrib>RIVO, JULIA</creatorcontrib><creatorcontrib>DASHEVSKY, OLGA</creatorcontrib><creatorcontrib>BRILL, ALEXANDER</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>VARON, DAVID</au><au>RIVO, JULIA</au><au>DASHEVSKY, OLGA</au><au>BRILL, ALEXANDER</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PLATELET-DERIVED MICROPARTICLES FOR THERAPY</title><date>2006-06-08</date><risdate>2006</risdate><abstract>The present invention provides methods for inducing or promoting angiogenesis in situ in which platelet derived microparticles (PMP) are administered to a target tissue or organ or in proximity with the tissue or organ. The methods of the invention may be used for treating conditions related to hypoxia such as ischemia. Also provided are compositions comprising as the active ingredient PMP for in situ induction or promotion of angiogenesis. A particular group of conditions to be treated by the methods and compositions of the present invention include heart diseases, specifically, cardiovascular diseases, more specifically, myocardial infarctions.
La présente invention concerne des méthodes propres à induire ou à favoriser un angiogenèse in situ, selon lesquelles on administre des microparticules d'origine plaquettaire (PMP) à un tissu ou à un organe cible, ou bien à proximité dudit tissu ou organe. Les méthodes de l'invention peuvent s'utiliser pour le traitement d'affections en rapport avec l'hypoxie tels que l'ischémie. L'invention concerne également des compositions contenant le principe actif PMP pour induction ou promotion in situ de l'angiogenèse. Un groupe particulier de pathologies à traiter au moyen des méthodes et des compositions de la présente invention est constitué par les affections cardiaques, en particulier les maladies cardio-vasculaires, et singulièrement les infarctus du myocarde.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | PLATELET-DERIVED MICROPARTICLES FOR THERAPY |
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