PLANT-PRODUCED RECOMBINANT APROTININ AND APROTININ VARIANTS

The present invention relates to plant produced native aprotinin and aprotinin variants having enzyme-inhibitory, immunological and pharmacokinetic properties and their preparation. In a preferred method a recombinant RNA plant virus is used to express native aprotinin + variants thereof in Nicotian...

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Bibliographische Detailangaben
Hauptverfasser:	GARGER, STEPHEN, J, VOJDANI, FAKHRIEH, S, POGUE, GREGORY, P, PALMER, KENNETH, E
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	AGRICULTURE ANIMAL HUSBANDRY BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE FISHING FORESTRY HUMAN NECESSITIES HUNTING METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NEW PLANTS OR PROCESSES FOR OBTAINING THEM ORGANIC CHEMISTRY PEPTIDES PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TRAPPING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to plant produced native aprotinin and aprotinin variants having enzyme-inhibitory, immunological and pharmacokinetic properties and their preparation. In a preferred method a recombinant RNA plant virus is used to express native aprotinin + variants thereof in Nicotiana plants. L'invention concerne l'aprotinine native d'origine végétale et des variants d'aprotinine possédant des propriétés inhibitrices enzymatiques, immunologiques et pharmacocinétiques, ainsi que leur préparation. Dans un procédé préféré, un phytovirus à ARN de recombinaison est utilisé pour exprimer l'aprotinine + des variants de celle-ci dans des plantes Nicotiana.