ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND METHODS OF USE

ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND METHODS OF USE

The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation, cancer and related conditions. The compounds have a general Formula I, wherein A1, A2, A3, B, R1, R2, R3 and R4 are defined herein. According...

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Hauptverfasser: WHITE, RYAN, CEE, VICTOR J, OLIVIERI, PHILIP R, PATEL, VINOD F, GRACEFFA, RUSSELL, BEMIS, JEAN E, HERBERICH, BRADLEY J, TOMLINSON, SUSAN ANN, HARMANGE, JEANRISTOPHE, LIU, GANG, DEMORIN, FRENEL F, CHAKRABARTI, PARTHA P, MARTIN, MATTHEW W, TEMPEST, PAUL A, ZHANG, DAWEI, XU, SHIMIN, DIMAURO, ERIN F, SHAM, KELVIN, PARAS, NICK A, BELLON, STEVEN, SMITH, ADRIAN LEONARD, REED, ANTHONY, ALBRECHT, BRIAN K, CAO, GUO-QIANG, THAMAN, MAYA C, RZASA, ROBERT M, DEAK, HOLLY L, KIM, JOSEPH L, GEUNS-MEYER, STEPHANIE D, MASSE, CRAIG E, BUCHANAN, JOHN L, HODOUS, BRIAN L, PETTUS, LIPING H, TASKER, ANDREW, FALSEY, JAMES RICHARD, MCGOWAN, DAVID C, CHAFFEE, STUART C, BUCKNER, WILLIAM H, HABGOOD, GREGORY J
Format: Patent
Sprache:eng ; fre
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Zusammenfassung:The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation, cancer and related conditions. The compounds have a general Formula I, wherein A1, A2, A3, B, R1, R2, R3 and R4 are defined herein. Accordingly, the invention also comprises pharmaceutical compositions comprising the compounds of the invention, methods for the prophylaxis and treatment of kinase mediated diseases using the compounds and compositions of the invention, and intermediates and processes useful for the preparation of compounds of the invention. La présente invention a trait à une nouvelle classe de composés utiles pour la prophylaxie et le traitement de maladies médiées par la protéine kinase, comprenant l'inflammation, le cancer et des conditions associées. Les composés sont de formule générale (I), dans laquelle: A