PHARMACEUTICAL COMPOSITION COMPRISING A SOLID DISPERSION WITH A POLYMER MATRIX CONTAINING A CONTINUOUS POLYDEXTROSE PHASE AND A CONTINUOUS PHASE OF A POLYMER OTHER THAN POLYDEXTROSE

PHARMACEUTICAL COMPOSITION COMPRISING A SOLID DISPERSION WITH A POLYMER MATRIX CONTAINING A CONTINUOUS POLYDEXTROSE PHASE AND A CONTINUOUS PHASE OF A POLYMER OTHER THAN POLYDEXTROSE

The invention relates to a solid pharmaceutical composition comprising a solid dispersion containing at least one active principle and a pharmaceutically-acceptable polymer matrix. The invention is characterised in that the pharmaceutically-acceptable polymer matrix comprises a mixture of (i) polyde...

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Hauptverfasser: RIBEIRO DOS SANTOS, ISABEL, BEDOS, MICHEL, BREUL, THIERRY, BYARD, STEPHEN
Format: Patent
Sprache:eng ; fre
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator RIBEIRO DOS SANTOS, ISABEL
BEDOS, MICHEL
BREUL, THIERRY
BYARD, STEPHEN
description The invention relates to a solid pharmaceutical composition comprising a solid dispersion containing at least one active principle and a pharmaceutically-acceptable polymer matrix. The invention is characterised in that the pharmaceutically-acceptable polymer matrix comprises a mixture of (i) polydextrose, in the form of a continuous polydextrose phase, in order to favour the disintegration of the composition in an aqueous medium and (ii) at least one polymer other than polydextrose, in the form of a continuous phase, whereby the polydextrose is in a concentration of at least 20 wt.- % and the at least one polymer other than polydextrose is in a concentration of at least 20 wt.- % in relation to the total weight of the pharmaceutically-acceptable polymer matrix. La présente invention se rapporte à une composition pharmaceutique solide comprenant une dispersion solide comprenant au moins un principe actif et une matrice polymère pharmaceutiquement acceptable, caractérisée en ce que ladite matrice polymère pharmaceutiquement acceptable comprend (i) du polydextrose pour favoriser la désagrégation de la composition en milieu aqueux, sous forme d'une phase continue de polydextrose, en mélange avec (ii) au moins un polymère autre que du polydextrose, sous forme d'une phase continue de ce polymère, la proportion dudit polydextrose étant d'au moins 20 % en poids et la proportion dudit au moins un polymère autre que du polydextrose étant d'au moins 20 % en poids, par rapport au poids total de ladite matrice polymère pharmaceutiquement acceptable.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title PHARMACEUTICAL COMPOSITION COMPRISING A SOLID DISPERSION WITH A POLYMER MATRIX CONTAINING A CONTINUOUS POLYDEXTROSE PHASE AND A CONTINUOUS PHASE OF A POLYMER OTHER THAN POLYDEXTROSE
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