COMPOSITIONS AND TREATMENTS FOR INHIBITING KINASE AND/OR HMG-COA REDUCTASE

The present invention provides compositions of matter, kits and methods for their use in the treatment of MAP kinase-related conditions and/or HMG-CoA reductase-related conditions. In particular, the invention provides compositions for treating inflammatory and/or cardiovascular conditions in an ani...

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Bibliographische Detailangaben
Hauptverfasser:	GRIFFIN, JOHN, YU, JESSEN, LANZA, GUIDO, MYDLOWEC, WILLIAM, J
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	FOODS OR FOODSTUFFS FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
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Beschreibung
Zusammenfassung:	The present invention provides compositions of matter, kits and methods for their use in the treatment of MAP kinase-related conditions and/or HMG-CoA reductase-related conditions. In particular, the invention provides compositions for treating inflammatory and/or cardiovascular conditions in an animal subject by inhibiting p38a MAP kinase and/or HMG-CoA reductase, as well as providing formulations and modes of administering such compositions. The invention further provides methods for the rational design of inhibitors of MAP kinase, HMG-CoA reductase, or both for use in the practice of the present invention. La présente invention a trait à des compositions de substance, des trousses et des procédés pour leur utilisation dans le traitement de conditions associées à la MAP-kinase et/ou de conditions associées à la HMG-CoA réductase. En particulier, l'invention a trait à des compositions pour le traitement de conditions inflammatoires et/ou cardio-vasculaires chez un sujet animal par l'inhibition de la MAP-kinase p38a et/ou la HMG-CoA réductase, ainsi qu'à des formulations et des modes d'administration de telles compositions. L'invention a également trait à des procédés pour la conception rationnelle d'inhibiteurs de la MAP kinase, la HMG-CoA réductase, ou des deux pour utilisation dans la mise en oeuvre de la présente invention.