MULTIPHASE BIOCOMPATIBLE SEMI-PERMEABLE MEMBRANE FOR BIOSENSORS
This invention relates to a novel two phase biocompatible semi-permeable mem- brane for biosensors and more particularly to a homogenous membrane for us- age in in-vivo sensing of glucose by an enzyme. The membrane comprises of a continuous hydrophilic phase of water swellable polyurethane having di...
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| creator | BUCH-RASMUSSEN, THOMAS GLEJBOEL, KRISTIAN GERSTENBERG, MICHAEL SABRA, MADS CHRISTIAN ROSSMEISL, CHARLOTTE C |
| description | This invention relates to a novel two phase biocompatible semi-permeable mem- brane for biosensors and more particularly to a homogenous membrane for us- age in in-vivo sensing of glucose by an enzyme. The membrane comprises of a continuous hydrophilic phase of water swellable polyurethane having discrete particles of polydimethyl siloxane dispersed therein. Furthermore, a membrane having good properties for use as the outer membrane in a biosensor continuous determination of the blood glucose level in vivo, can be prepared by spraying of a polymer solution in a big number of spraying steps, for example, more than 20 steps.
La présente invention concerne une membrane semi-perméable bi-phase biocompatible pour biocapteurs, et plus particulièrement une membrane homogène destiné à la détection in-vivo du glucose par une enzyme. Cette membrane est faite d'une phase hydrophile continue de polyuréthane gonflant par l'eau dans laquelle sont dispersées des particules discrètes de polydiméthyle-siloxane. L'invention concerne en outre une membrane présentant de bonne propriétés pour une utilisation comme membrane extérieure d'un biocapteur de détermination continue de la glycémie in-vivo, et que l'on peut élaborer en pulvérisant une solution de polymère dans un grand nombre d'opérations de pulvérisation, par exemple, plus de 20 opérations. |
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La présente invention concerne une membrane semi-perméable bi-phase biocompatible pour biocapteurs, et plus particulièrement une membrane homogène destiné à la détection in-vivo du glucose par une enzyme. Cette membrane est faite d'une phase hydrophile continue de polyuréthane gonflant par l'eau dans laquelle sont dispersées des particules discrètes de polydiméthyle-siloxane. L'invention concerne en outre une membrane présentant de bonne propriétés pour une utilisation comme membrane extérieure d'un biocapteur de détermination continue de la glycémie in-vivo, et que l'on peut élaborer en pulvérisant une solution de polymère dans un grand nombre d'opérations de pulvérisation, par exemple, plus de 20 opérations.</description><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS OR TEST PAPERS THEREFOR ; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ; DIAGNOSIS ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; IDENTIFICATION ; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MUTATION OR GENETIC ENGINEERING ; PERFORMING OPERATIONS ; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL ; PROCESSES OF PREPARING SUCH COMPOSITIONS ; SEPARATION ; SPIRITS ; SURGERY ; TRANSPORTING ; VINEGAR ; WINE</subject><creationdate>2006</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20060608&DB=EPODOC&CC=WO&NR=2006018425A3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20060608&DB=EPODOC&CC=WO&NR=2006018425A3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>BUCH-RASMUSSEN, THOMAS</creatorcontrib><creatorcontrib>GLEJBOEL, KRISTIAN</creatorcontrib><creatorcontrib>GERSTENBERG, MICHAEL</creatorcontrib><creatorcontrib>SABRA, MADS CHRISTIAN</creatorcontrib><creatorcontrib>ROSSMEISL, CHARLOTTE C</creatorcontrib><title>MULTIPHASE BIOCOMPATIBLE SEMI-PERMEABLE MEMBRANE FOR BIOSENSORS</title><description>This invention relates to a novel two phase biocompatible semi-permeable mem- brane for biosensors and more particularly to a homogenous membrane for us- age in in-vivo sensing of glucose by an enzyme. The membrane comprises of a continuous hydrophilic phase of water swellable polyurethane having discrete particles of polydimethyl siloxane dispersed therein. Furthermore, a membrane having good properties for use as the outer membrane in a biosensor continuous determination of the blood glucose level in vivo, can be prepared by spraying of a polymer solution in a big number of spraying steps, for example, more than 20 steps.
La présente invention concerne une membrane semi-perméable bi-phase biocompatible pour biocapteurs, et plus particulièrement une membrane homogène destiné à la détection in-vivo du glucose par une enzyme. Cette membrane est faite d'une phase hydrophile continue de polyuréthane gonflant par l'eau dans laquelle sont dispersées des particules discrètes de polydiméthyle-siloxane. 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The membrane comprises of a continuous hydrophilic phase of water swellable polyurethane having discrete particles of polydimethyl siloxane dispersed therein. Furthermore, a membrane having good properties for use as the outer membrane in a biosensor continuous determination of the blood glucose level in vivo, can be prepared by spraying of a polymer solution in a big number of spraying steps, for example, more than 20 steps.
La présente invention concerne une membrane semi-perméable bi-phase biocompatible pour biocapteurs, et plus particulièrement une membrane homogène destiné à la détection in-vivo du glucose par une enzyme. Cette membrane est faite d'une phase hydrophile continue de polyuréthane gonflant par l'eau dans laquelle sont dispersées des particules discrètes de polydiméthyle-siloxane. L'invention concerne en outre une membrane présentant de bonne propriétés pour une utilisation comme membrane extérieure d'un biocapteur de détermination continue de la glycémie in-vivo, et que l'on peut élaborer en pulvérisant une solution de polymère dans un grand nombre d'opérations de pulvérisation, par exemple, plus de 20 opérations.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES DIAGNOSIS ENZYMOLOGY HUMAN NECESSITIES HYGIENE IDENTIFICATION MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PROCESSES OF PREPARING SUCH COMPOSITIONS SEPARATION SPIRITS SURGERY TRANSPORTING VINEGAR WINE |
| title | MULTIPHASE BIOCOMPATIBLE SEMI-PERMEABLE MEMBRANE FOR BIOSENSORS |
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