METHODS FOR THE DELIVERY OF OLIGOMERIC COMPOUNDS
The presently disclosed subject matter relates to the delivery of oligonucleotides to cells through the delivery of a composition or reagent comprising a hybridization complex comprising a first antisense oligonucleotide which is modified to have a higher stability against degradation, and a second...
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| creator | HERDEWIJN, PIET JULIANO, RUDY KANG, HYUNMIN CHALTIN, PATRICK VAN AERSCHOT, ARTHUR ASTRIAB-FISHER, ANNA |
| description | The presently disclosed subject matter relates to the delivery of oligonucleotides to cells through the delivery of a composition or reagent comprising a hybridization complex comprising a first antisense oligonucleotide which is modified to have a higher stability against degradation, and a second sense oligonucleotide which is prone to degradation. The presently disclosed subject matter furthermore relates to dendrimeric bioconjugates and compositions or reagents comprising them, wherein the bioconjugate comprises a conjugate moiety coupled to a dendrimeric structure and to their use to deliver oligomeric compounds including oligonucleotides or duplexes, as described above, to cells for modulation of gene expression (i.e. antisense or antigene therapy/research, RNA interference).
L'invention porte sur la délivrance oligonucléotides à des cellules via la délivrance d'une composition ou d'un réactif comportant un complexe d'hybridation comportant un premier oligonucléotide antisens modifié pour présenter une stabilité plus importante vis à vis de la dégradation, eu un deuxième oligonucléotide sens enclin à la dégradation. L'invention porte également sur des bioconjugués dendrimères et des composés et réactifs les incluant, lesdits bioconjugués comprenant un fragment de conjugué couplé à une structure dendrimère, et sur leur utilisation pour délivrer des composés oligomères incluant des oligonucléotides ou des duplexes tels que décrits ci-dessus, à des cellules en vue de la modulation d'expressions géniques ( c.-à-d. de thérapie ou de recherche utilisant des antisens ou des antigènes et d'interférences de l'ARN. |
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L'invention porte sur la délivrance oligonucléotides à des cellules via la délivrance d'une composition ou d'un réactif comportant un complexe d'hybridation comportant un premier oligonucléotide antisens modifié pour présenter une stabilité plus importante vis à vis de la dégradation, eu un deuxième oligonucléotide sens enclin à la dégradation. L'invention porte également sur des bioconjugués dendrimères et des composés et réactifs les incluant, lesdits bioconjugués comprenant un fragment de conjugué couplé à une structure dendrimère, et sur leur utilisation pour délivrer des composés oligomères incluant des oligonucléotides ou des duplexes tels que décrits ci-dessus, à des cellules en vue de la modulation d'expressions géniques ( c.-à-d. de thérapie ou de recherche utilisant des antisens ou des antigènes et d'interférences de l'ARN.</description><edition>7</edition><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; DERIVATIVES THEREOF ; ENZYMOLOGY ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; NUCLEIC ACIDS ; NUCLEOSIDES ; NUCLEOTIDES ; ORGANIC CHEMISTRY ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; SUGARS ; VINEGAR ; WINE</subject><creationdate>2005</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20051201&DB=EPODOC&CC=WO&NR=2005113571A2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20051201&DB=EPODOC&CC=WO&NR=2005113571A2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HERDEWIJN, PIET</creatorcontrib><creatorcontrib>JULIANO, RUDY</creatorcontrib><creatorcontrib>KANG, HYUNMIN</creatorcontrib><creatorcontrib>CHALTIN, PATRICK</creatorcontrib><creatorcontrib>VAN AERSCHOT, ARTHUR</creatorcontrib><creatorcontrib>ASTRIAB-FISHER, ANNA</creatorcontrib><title>METHODS FOR THE DELIVERY OF OLIGOMERIC COMPOUNDS</title><description>The presently disclosed subject matter relates to the delivery of oligonucleotides to cells through the delivery of a composition or reagent comprising a hybridization complex comprising a first antisense oligonucleotide which is modified to have a higher stability against degradation, and a second sense oligonucleotide which is prone to degradation. The presently disclosed subject matter furthermore relates to dendrimeric bioconjugates and compositions or reagents comprising them, wherein the bioconjugate comprises a conjugate moiety coupled to a dendrimeric structure and to their use to deliver oligomeric compounds including oligonucleotides or duplexes, as described above, to cells for modulation of gene expression (i.e. antisense or antigene therapy/research, RNA interference).
L'invention porte sur la délivrance oligonucléotides à des cellules via la délivrance d'une composition ou d'un réactif comportant un complexe d'hybridation comportant un premier oligonucléotide antisens modifié pour présenter une stabilité plus importante vis à vis de la dégradation, eu un deuxième oligonucléotide sens enclin à la dégradation. L'invention porte également sur des bioconjugués dendrimères et des composés et réactifs les incluant, lesdits bioconjugués comprenant un fragment de conjugué couplé à une structure dendrimère, et sur leur utilisation pour délivrer des composés oligomères incluant des oligonucléotides ou des duplexes tels que décrits ci-dessus, à des cellules en vue de la modulation d'expressions géniques ( c.-à-d. de thérapie ou de recherche utilisant des antisens ou des antigènes et d'interférences de l'ARN.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>DERIVATIVES THEREOF</subject><subject>ENZYMOLOGY</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>NUCLEIC ACIDS</subject><subject>NUCLEOSIDES</subject><subject>NUCLEOTIDES</subject><subject>ORGANIC CHEMISTRY</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>SUGARS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2005</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDDwdQ3x8HcJVnDzD1II8XBVcHH18QxzDYpU8HdT8PfxdPf3dQ3ydFZw9vcN8A_1cwnmYWBNS8wpTuWF0twMym6uIc4euqkF-fGpxQWJyal5qSXx4f5GBgamhobGpuaGjkbGxKkCAMYSJzI</recordid><startdate>20051201</startdate><enddate>20051201</enddate><creator>HERDEWIJN, PIET</creator><creator>JULIANO, RUDY</creator><creator>KANG, HYUNMIN</creator><creator>CHALTIN, PATRICK</creator><creator>VAN AERSCHOT, ARTHUR</creator><creator>ASTRIAB-FISHER, ANNA</creator><scope>EVB</scope></search><sort><creationdate>20051201</creationdate><title>METHODS FOR THE DELIVERY OF OLIGOMERIC COMPOUNDS</title><author>HERDEWIJN, PIET ; JULIANO, RUDY ; KANG, HYUNMIN ; CHALTIN, PATRICK ; VAN AERSCHOT, ARTHUR ; ASTRIAB-FISHER, ANNA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2005113571A23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2005</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>DERIVATIVES THEREOF</topic><topic>ENZYMOLOGY</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>NUCLEIC ACIDS</topic><topic>NUCLEOSIDES</topic><topic>NUCLEOTIDES</topic><topic>ORGANIC CHEMISTRY</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>SUGARS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>HERDEWIJN, PIET</creatorcontrib><creatorcontrib>JULIANO, RUDY</creatorcontrib><creatorcontrib>KANG, HYUNMIN</creatorcontrib><creatorcontrib>CHALTIN, PATRICK</creatorcontrib><creatorcontrib>VAN AERSCHOT, ARTHUR</creatorcontrib><creatorcontrib>ASTRIAB-FISHER, ANNA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>HERDEWIJN, PIET</au><au>JULIANO, RUDY</au><au>KANG, HYUNMIN</au><au>CHALTIN, PATRICK</au><au>VAN AERSCHOT, ARTHUR</au><au>ASTRIAB-FISHER, ANNA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>METHODS FOR THE DELIVERY OF OLIGOMERIC COMPOUNDS</title><date>2005-12-01</date><risdate>2005</risdate><abstract>The presently disclosed subject matter relates to the delivery of oligonucleotides to cells through the delivery of a composition or reagent comprising a hybridization complex comprising a first antisense oligonucleotide which is modified to have a higher stability against degradation, and a second sense oligonucleotide which is prone to degradation. The presently disclosed subject matter furthermore relates to dendrimeric bioconjugates and compositions or reagents comprising them, wherein the bioconjugate comprises a conjugate moiety coupled to a dendrimeric structure and to their use to deliver oligomeric compounds including oligonucleotides or duplexes, as described above, to cells for modulation of gene expression (i.e. antisense or antigene therapy/research, RNA interference).
L'invention porte sur la délivrance oligonucléotides à des cellules via la délivrance d'une composition ou d'un réactif comportant un complexe d'hybridation comportant un premier oligonucléotide antisens modifié pour présenter une stabilité plus importante vis à vis de la dégradation, eu un deuxième oligonucléotide sens enclin à la dégradation. L'invention porte également sur des bioconjugués dendrimères et des composés et réactifs les incluant, lesdits bioconjugués comprenant un fragment de conjugué couplé à une structure dendrimère, et sur leur utilisation pour délivrer des composés oligomères incluant des oligonucléotides ou des duplexes tels que décrits ci-dessus, à des cellules en vue de la modulation d'expressions géniques ( c.-à-d. de thérapie ou de recherche utilisant des antisens ou des antigènes et d'interférences de l'ARN.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA DERIVATIVES THEREOF ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS SUGARS VINEGAR WINE |
| title | METHODS FOR THE DELIVERY OF OLIGOMERIC COMPOUNDS |
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