SUBSTITUTED 3-AMINO-THIENO[2,3-B] PYRIDINE-2-CARBOXYLIC ACID AMIDE COMPOUNDS AS IKK INHIBITORS
Disclosed are compounds of formula (I): wherein the variables R1, R2, R3 and Z are described herein, which are useful as inhibitors of the kinase activity of the IkappaB kinase (IKK) complex. The compounds are therefore useful in the treatment of IKK mediated diseases including autoimmune diseases i...
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| creator | WU, LIFEN CHEN, ZHIDONG LIU, WEIMIN YOUNG, ERICK, RICHARD, ROUSH CIRILLO, PIER, FRANCESCO MARSHALL, DANIEL, RICHARD DISALVO, DARREN |
| description | Disclosed are compounds of formula (I): wherein the variables R1, R2, R3 and Z are described herein, which are useful as inhibitors of the kinase activity of the IkappaB kinase (IKK) complex. The compounds are therefore useful in the treatment of IKK mediated diseases including autoimmune diseases inflammatory diseases and cancer. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.
L'invention concerne des composés de formule (I). Dans cette formule, les variables R1, R2, R3 et Z sont décrites dans la description. Les composés de l'invention sont utiles en tant qu'inhibiteurs de l'activité de la kinase du complexe de kinase I kappa B (IKK). Les composés de l'invention sont par conséquent utiles dans le traitement de maladies médiées par IKK, notamment des maladies auto-immunes, des maladies inflammatoires et le cancer. L'invention concerne des compositions pharmaceutiques comprenant ces composés, et des procédés pour préparer ces composés. |
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L'invention concerne des composés de formule (I). Dans cette formule, les variables R1, R2, R3 et Z sont décrites dans la description. Les composés de l'invention sont utiles en tant qu'inhibiteurs de l'activité de la kinase du complexe de kinase I kappa B (IKK). Les composés de l'invention sont par conséquent utiles dans le traitement de maladies médiées par IKK, notamment des maladies auto-immunes, des maladies inflammatoires et le cancer. L'invention concerne des compositions pharmaceutiques comprenant ces composés, et des procédés pour préparer ces composés.</description><edition>7</edition><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2005</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20050623&DB=EPODOC&CC=WO&NR=2005056562A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20050623&DB=EPODOC&CC=WO&NR=2005056562A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>WU, LIFEN</creatorcontrib><creatorcontrib>CHEN, ZHIDONG</creatorcontrib><creatorcontrib>LIU, WEIMIN</creatorcontrib><creatorcontrib>YOUNG, ERICK, RICHARD, ROUSH</creatorcontrib><creatorcontrib>CIRILLO, PIER, FRANCESCO</creatorcontrib><creatorcontrib>MARSHALL, DANIEL, RICHARD</creatorcontrib><creatorcontrib>DISALVO, DARREN</creatorcontrib><title>SUBSTITUTED 3-AMINO-THIENO[2,3-B] PYRIDINE-2-CARBOXYLIC ACID AMIDE COMPOUNDS AS IKK INHIBITORS</title><description>Disclosed are compounds of formula (I): wherein the variables R1, R2, R3 and Z are described herein, which are useful as inhibitors of the kinase activity of the IkappaB kinase (IKK) complex. The compounds are therefore useful in the treatment of IKK mediated diseases including autoimmune diseases inflammatory diseases and cancer. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.
L'invention concerne des composés de formule (I). Dans cette formule, les variables R1, R2, R3 et Z sont décrites dans la description. Les composés de l'invention sont utiles en tant qu'inhibiteurs de l'activité de la kinase du complexe de kinase I kappa B (IKK). Les composés de l'invention sont par conséquent utiles dans le traitement de maladies médiées par IKK, notamment des maladies auto-immunes, des maladies inflammatoires et le cancer. L'invention concerne des compositions pharmaceutiques comprenant ces composés, et des procédés pour préparer ces composés.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2005</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNyrsKwjAUANAuDqL-wwVXAzWl3fOSXmpzS5NQi2gpEifRQv1_dPADnM5ylsnVBek8-uCNhoyJGi0xX6KxdOa7jMkLNH2LGq1hnCnRSjr1R1QgFGr4dm1AUd1QsNqBcIBVBWhLlOipdetkcR8fc9z8XCXbg_GqZHF6DXGexlt8xvfQEU_TPM2LvOBin_23PsZPM4o</recordid><startdate>20050623</startdate><enddate>20050623</enddate><creator>WU, LIFEN</creator><creator>CHEN, ZHIDONG</creator><creator>LIU, WEIMIN</creator><creator>YOUNG, ERICK, RICHARD, ROUSH</creator><creator>CIRILLO, PIER, FRANCESCO</creator><creator>MARSHALL, DANIEL, RICHARD</creator><creator>DISALVO, DARREN</creator><scope>EVB</scope></search><sort><creationdate>20050623</creationdate><title>SUBSTITUTED 3-AMINO-THIENO[2,3-B] PYRIDINE-2-CARBOXYLIC ACID AMIDE COMPOUNDS AS IKK INHIBITORS</title><author>WU, LIFEN ; CHEN, ZHIDONG ; LIU, WEIMIN ; YOUNG, ERICK, RICHARD, ROUSH ; CIRILLO, PIER, FRANCESCO ; MARSHALL, DANIEL, RICHARD ; DISALVO, DARREN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2005056562A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2005</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>WU, LIFEN</creatorcontrib><creatorcontrib>CHEN, ZHIDONG</creatorcontrib><creatorcontrib>LIU, WEIMIN</creatorcontrib><creatorcontrib>YOUNG, ERICK, RICHARD, ROUSH</creatorcontrib><creatorcontrib>CIRILLO, PIER, FRANCESCO</creatorcontrib><creatorcontrib>MARSHALL, DANIEL, RICHARD</creatorcontrib><creatorcontrib>DISALVO, DARREN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>WU, LIFEN</au><au>CHEN, ZHIDONG</au><au>LIU, WEIMIN</au><au>YOUNG, ERICK, RICHARD, ROUSH</au><au>CIRILLO, PIER, FRANCESCO</au><au>MARSHALL, DANIEL, RICHARD</au><au>DISALVO, DARREN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>SUBSTITUTED 3-AMINO-THIENO[2,3-B] PYRIDINE-2-CARBOXYLIC ACID AMIDE COMPOUNDS AS IKK INHIBITORS</title><date>2005-06-23</date><risdate>2005</risdate><abstract>Disclosed are compounds of formula (I): wherein the variables R1, R2, R3 and Z are described herein, which are useful as inhibitors of the kinase activity of the IkappaB kinase (IKK) complex. The compounds are therefore useful in the treatment of IKK mediated diseases including autoimmune diseases inflammatory diseases and cancer. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.
L'invention concerne des composés de formule (I). Dans cette formule, les variables R1, R2, R3 et Z sont décrites dans la description. Les composés de l'invention sont utiles en tant qu'inhibiteurs de l'activité de la kinase du complexe de kinase I kappa B (IKK). Les composés de l'invention sont par conséquent utiles dans le traitement de maladies médiées par IKK, notamment des maladies auto-immunes, des maladies inflammatoires et le cancer. L'invention concerne des compositions pharmaceutiques comprenant ces composés, et des procédés pour préparer ces composés.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | SUBSTITUTED 3-AMINO-THIENO[2,3-B] PYRIDINE-2-CARBOXYLIC ACID AMIDE COMPOUNDS AS IKK INHIBITORS |
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