GSK-3 INHIBITORS AND USES THEREOF

This invention relates to methods of treating or preventing bone loss by administering to a human or animal subject pyrimidine and pyridine derivatives that inhibit the activity of glycogen synthase kinase 3 (GSK3), to pharmaceutical compositions containing the compounds, and to the use of the compo...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	HARRISON, STEPHEN, D, LONGO, KENNETH, A, WAGMAN, ALLAN, S, HANKENSON, KURT, D, MACDONALD, ORMOND, A, BENNETT, CHRISTINA, N
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	This invention relates to methods of treating or preventing bone loss by administering to a human or animal subject pyrimidine and pyridine derivatives that inhibit the activity of glycogen synthase kinase 3 (GSK3), to pharmaceutical compositions containing the compounds, and to the use of the compounds and compositions alone or in combination with other pharmaceutically active agents. L'invention concerne des méthodes de traitement ou de prévention de la perte osseuse, consistant à administrer à un patient ou à un animal des dérivés de pyrimidine et de pyridine inhibant l'activité de la glycogène synthase kinase 3 (GSK3), des compositions pharmaceutiques contenant lesdits composés, et l'utilisation desdits composés et compositions seuls ou combinés à d'autres agents actifs d'un point de vue pharmaceutique.