CILIARY NEUROTROPHIC FACTOR VARIANTS
The present invention relates to variant ciliary neurotrophic factor (CNTF) proteins that possess neuroprotective and/or weight loss activity and reduced immunogenicity. In particular, variants of CNTF with reduced ability to bind one or more human class II MHC molecules are described. L'invent...
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| creator | BARBOSA, MARIA, D.F.S MARSHALL, SHANNON, ALICIA |
| description | The present invention relates to variant ciliary neurotrophic factor (CNTF) proteins that possess neuroprotective and/or weight loss activity and reduced immunogenicity. In particular, variants of CNTF with reduced ability to bind one or more human class II MHC molecules are described.
L'invention concerne des protéines de variants de facteur neurotrophique ciliaire (CNTF) présentant une activité neuroprotectrice et/ou de perte de poids et une immunogénicité réduite. En particulier, l'invention concerne des variants de CNTF présentant une capacité réduite à se lier à au moins une molécule MHC de classe II humaine. |
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L'invention concerne des protéines de variants de facteur neurotrophique ciliaire (CNTF) présentant une activité neuroprotectrice et/ou de perte de poids et une immunogénicité réduite. En particulier, l'invention concerne des variants de CNTF présentant une capacité réduite à se lier à au moins une molécule MHC de classe II humaine.</description><edition>7</edition><language>eng ; fre</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2005</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20050217&DB=EPODOC&CC=WO&NR=2005014641A2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76318</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20050217&DB=EPODOC&CC=WO&NR=2005014641A2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>BARBOSA, MARIA, D.F.S</creatorcontrib><creatorcontrib>MARSHALL, SHANNON, ALICIA</creatorcontrib><title>CILIARY NEUROTROPHIC FACTOR VARIANTS</title><description>The present invention relates to variant ciliary neurotrophic factor (CNTF) proteins that possess neuroprotective and/or weight loss activity and reduced immunogenicity. In particular, variants of CNTF with reduced ability to bind one or more human class II MHC molecules are described.
L'invention concerne des protéines de variants de facteur neurotrophique ciliaire (CNTF) présentant une activité neuroprotectrice et/ou de perte de poids et une immunogénicité réduite. En particulier, l'invention concerne des variants de CNTF présentant une capacité réduite à se lier à au moins une molécule MHC de classe II humaine.</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2005</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFBx9vTxdAyKVPBzDQ3yDwnyD_DwdFZwc3QO8Q9SCHMM8nT0CwnmYWBNS8wpTuWF0twMym6uIc4euqkF-fGpxQWJyal5qSXx4f5GBgamBoYmZiaGjkbGxKkCACU9JCE</recordid><startdate>20050217</startdate><enddate>20050217</enddate><creator>BARBOSA, MARIA, D.F.S</creator><creator>MARSHALL, SHANNON, ALICIA</creator><scope>EVB</scope></search><sort><creationdate>20050217</creationdate><title>CILIARY NEUROTROPHIC FACTOR VARIANTS</title><author>BARBOSA, MARIA, D.F.S ; MARSHALL, SHANNON, ALICIA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2005014641A23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2005</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>BARBOSA, MARIA, D.F.S</creatorcontrib><creatorcontrib>MARSHALL, SHANNON, ALICIA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>BARBOSA, MARIA, D.F.S</au><au>MARSHALL, SHANNON, ALICIA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>CILIARY NEUROTROPHIC FACTOR VARIANTS</title><date>2005-02-17</date><risdate>2005</risdate><abstract>The present invention relates to variant ciliary neurotrophic factor (CNTF) proteins that possess neuroprotective and/or weight loss activity and reduced immunogenicity. In particular, variants of CNTF with reduced ability to bind one or more human class II MHC molecules are described.
L'invention concerne des protéines de variants de facteur neurotrophique ciliaire (CNTF) présentant une activité neuroprotectrice et/ou de perte de poids et une immunogénicité réduite. En particulier, l'invention concerne des variants de CNTF présentant une capacité réduite à se lier à au moins une molécule MHC de classe II humaine.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| language | eng ; fre |
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| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | CILIARY NEUROTROPHIC FACTOR VARIANTS |
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