AN IMPROVED PROCESS FOR THE MANUFACTURE OF ISRADIPINE
The present invention relates to an improved method for the manufacture of Isradipine, 4-(4-Benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid methyl 1-methylethyl ester. which, involves reacting 2,1,3-benzoxadiazole-4-carboxaldehyde with methyl acetoacetate in the presence of ac...
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| creator | MULLAIYUR, RADHAKRISHNAN, SELVARAJU SENTHIL, KUMAR, MINOR THAKASHINAMOORTHY, CHANDIRAN PALANIVEL, KALIYAPERUMAL |
| description | The present invention relates to an improved method for the manufacture of Isradipine, 4-(4-Benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid methyl 1-methylethyl ester. which, involves reacting 2,1,3-benzoxadiazole-4-carboxaldehyde with methyl acetoacetate in the presence of acetic acid and piperidine in diisopropyl ether. To obtain the product 2-acetyl-3-benzofurazan-4-yl-acrylic acid methyl ester which is then reacted with isopropyl-ß-aminocrotonate in ethanol at 25 to 35°C to obtain the product.
La présente invention concerne un procédé amélioré de fabrication d'Isradipine, ester de méthyle 1-méthylethyle d'acide 4-(4-benzofurazanyl)-1,4-dihydro-2,6-diméthyl-3,5-pyridinedicarboxylique. Elle consiste à faire réagir 2,1,3-benzoxadiazole-4-carboxaldéhyde avec un acétoacétate de méthyl en présence d'acide acétique et de pipéridine dans un éther diisopropylique. Pour obtenir le produit, on utilise l'ester de méthyle d'acide 2-acétyl-3-benzofurazan-4-yl-acrylique, qu'on fait ensuite réagir avec isopropyl-ss-aminocrotonate dans de l'éthanol à 25 - 35 DEG C. |
| format | Patent |
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La présente invention concerne un procédé amélioré de fabrication d'Isradipine, ester de méthyle 1-méthylethyle d'acide 4-(4-benzofurazanyl)-1,4-dihydro-2,6-diméthyl-3,5-pyridinedicarboxylique. Elle consiste à faire réagir 2,1,3-benzoxadiazole-4-carboxaldéhyde avec un acétoacétate de méthyl en présence d'acide acétique et de pipéridine dans un éther diisopropylique. Pour obtenir le produit, on utilise l'ester de méthyle d'acide 2-acétyl-3-benzofurazan-4-yl-acrylique, qu'on fait ensuite réagir avec isopropyl-ss-aminocrotonate dans de l'éthanol à 25 - 35 DEG C.</description><edition>7</edition><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2005</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20050120&DB=EPODOC&CC=WO&NR=2005005437A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76418</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20050120&DB=EPODOC&CC=WO&NR=2005005437A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MULLAIYUR, RADHAKRISHNAN, SELVARAJU</creatorcontrib><creatorcontrib>SENTHIL, KUMAR, MINOR</creatorcontrib><creatorcontrib>THAKASHINAMOORTHY, CHANDIRAN</creatorcontrib><creatorcontrib>PALANIVEL, KALIYAPERUMAL</creatorcontrib><title>AN IMPROVED PROCESS FOR THE MANUFACTURE OF ISRADIPINE</title><description>The present invention relates to an improved method for the manufacture of Isradipine, 4-(4-Benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid methyl 1-methylethyl ester. which, involves reacting 2,1,3-benzoxadiazole-4-carboxaldehyde with methyl acetoacetate in the presence of acetic acid and piperidine in diisopropyl ether. To obtain the product 2-acetyl-3-benzofurazan-4-yl-acrylic acid methyl ester which is then reacted with isopropyl-ß-aminocrotonate in ethanol at 25 to 35°C to obtain the product.
La présente invention concerne un procédé amélioré de fabrication d'Isradipine, ester de méthyle 1-méthylethyle d'acide 4-(4-benzofurazanyl)-1,4-dihydro-2,6-diméthyl-3,5-pyridinedicarboxylique. Elle consiste à faire réagir 2,1,3-benzoxadiazole-4-carboxaldéhyde avec un acétoacétate de méthyl en présence d'acide acétique et de pipéridine dans un éther diisopropylique. Pour obtenir le produit, on utilise l'ester de méthyle d'acide 2-acétyl-3-benzofurazan-4-yl-acrylique, qu'on fait ensuite réagir avec isopropyl-ss-aminocrotonate dans de l'éthanol à 25 - 35 DEG C.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2005</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDB19FPw9A0I8g9zdVEAUs6uwcEKbv5BCiEergq-jn6hbo7OIaFBrgr-bgqewUGOLp4Bnn6uPAysaYk5xam8UJqbQdnNNcTZQze1ID8-tbggMTk1L7UkPtzfyMDAFIhMjM0dDY2JUwUAgQkodA</recordid><startdate>20050120</startdate><enddate>20050120</enddate><creator>MULLAIYUR, RADHAKRISHNAN, SELVARAJU</creator><creator>SENTHIL, KUMAR, MINOR</creator><creator>THAKASHINAMOORTHY, CHANDIRAN</creator><creator>PALANIVEL, KALIYAPERUMAL</creator><scope>EVB</scope></search><sort><creationdate>20050120</creationdate><title>AN IMPROVED PROCESS FOR THE MANUFACTURE OF ISRADIPINE</title><author>MULLAIYUR, RADHAKRISHNAN, SELVARAJU ; SENTHIL, KUMAR, MINOR ; THAKASHINAMOORTHY, CHANDIRAN ; PALANIVEL, KALIYAPERUMAL</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2005005437A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2005</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>MULLAIYUR, RADHAKRISHNAN, SELVARAJU</creatorcontrib><creatorcontrib>SENTHIL, KUMAR, MINOR</creatorcontrib><creatorcontrib>THAKASHINAMOORTHY, CHANDIRAN</creatorcontrib><creatorcontrib>PALANIVEL, KALIYAPERUMAL</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>MULLAIYUR, RADHAKRISHNAN, SELVARAJU</au><au>SENTHIL, KUMAR, MINOR</au><au>THAKASHINAMOORTHY, CHANDIRAN</au><au>PALANIVEL, KALIYAPERUMAL</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>AN IMPROVED PROCESS FOR THE MANUFACTURE OF ISRADIPINE</title><date>2005-01-20</date><risdate>2005</risdate><abstract>The present invention relates to an improved method for the manufacture of Isradipine, 4-(4-Benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid methyl 1-methylethyl ester. which, involves reacting 2,1,3-benzoxadiazole-4-carboxaldehyde with methyl acetoacetate in the presence of acetic acid and piperidine in diisopropyl ether. To obtain the product 2-acetyl-3-benzofurazan-4-yl-acrylic acid methyl ester which is then reacted with isopropyl-ß-aminocrotonate in ethanol at 25 to 35°C to obtain the product.
La présente invention concerne un procédé amélioré de fabrication d'Isradipine, ester de méthyle 1-méthylethyle d'acide 4-(4-benzofurazanyl)-1,4-dihydro-2,6-diméthyl-3,5-pyridinedicarboxylique. Elle consiste à faire réagir 2,1,3-benzoxadiazole-4-carboxaldéhyde avec un acétoacétate de méthyl en présence d'acide acétique et de pipéridine dans un éther diisopropylique. Pour obtenir le produit, on utilise l'ester de méthyle d'acide 2-acétyl-3-benzofurazan-4-yl-acrylique, qu'on fait ensuite réagir avec isopropyl-ss-aminocrotonate dans de l'éthanol à 25 - 35 DEG C.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| title | AN IMPROVED PROCESS FOR THE MANUFACTURE OF ISRADIPINE |
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