PROCESSES FOR THE PREPARATION OF N-((((PYRIDINYLOXY) -PHENYLAMINO) QUINAZOLINYL)- ALLYL) ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS WELL AS INTERMEDIATES OF SUCH PROCESSES AND PROCESSES FOR THE PREPARATION OF SUCH INTERMEDIATES
The invention relates to processes for preparing compounds of the formula (1) and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R , R , R , R R , R R R , R , R , k, I, and m are as defined herein. The present invention also relates to intermediates represented by the f...
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| creator | VETELINO, MICHAEL, GIRARD RIPIN, DAVID, HAROLD, BROWN WEI, LULIN |
| description | The invention relates to processes for preparing compounds of the formula (1) and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R , R , R , R R , R R R , R , R , k, I, and m are as defined herein. The present invention also relates to intermediates represented by the formula (3a) wherin R , and R are independently selected from hydrogen and C1-C6 alkyl; each R , R , R and R is independently selected from hydrogen, C1-C6 alkyl and CH2OH, R and R are independently C1-C6 alkyl, and k and I are independently an integer from 1 to 3, as well as to a process for preparing these intermediates.
L'invention se rapporte à des procédés de préparation de composés de la formule (1) et à leurs sels pharmaceutiquement acceptables, à leurs promédicaments et solvates; formule dans laquelle R , R , R , R , R , R , R , R , R , R , k, l, et m sont tels que definis. La présente invention concerne également des intermédiaires représentés par la formule (3a), dans laquelle R et R sont indépendamment choisis entre hydrogène et C1-C6 alkyle; R , R , R et R sont chacun indépendamment choisis entre hydrogène, C1-C6 alkyle et CH2OH, R et R représentent indépendamment C1-C6 alkyle, et k et l représentent indépendamment un entier compris entre 1 et 3; et un procédé de préparation de ces intermédiaires. |
| format | Patent |
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L'invention se rapporte à des procédés de préparation de composés de la formule (1) et à leurs sels pharmaceutiquement acceptables, à leurs promédicaments et solvates; formule dans laquelle R , R , R , R , R , R , R , R , R , R , k, l, et m sont tels que definis. La présente invention concerne également des intermédiaires représentés par la formule (3a), dans laquelle R et R sont indépendamment choisis entre hydrogène et C1-C6 alkyle; R , R , R et R sont chacun indépendamment choisis entre hydrogène, C1-C6 alkyle et CH2OH, R et R représentent indépendamment C1-C6 alkyle, et k et l représentent indépendamment un entier compris entre 1 et 3; et un procédé de préparation de ces intermédiaires.</description><edition>7</edition><language>eng ; fre</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2004</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20041021&DB=EPODOC&CC=WO&NR=2004089934A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20041021&DB=EPODOC&CC=WO&NR=2004089934A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>VETELINO, MICHAEL, GIRARD</creatorcontrib><creatorcontrib>RIPIN, DAVID, HAROLD, BROWN</creatorcontrib><creatorcontrib>WEI, LULIN</creatorcontrib><title>PROCESSES FOR THE PREPARATION OF N-((((PYRIDINYLOXY) -PHENYLAMINO) QUINAZOLINYL)- ALLYL) ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS WELL AS INTERMEDIATES OF SUCH PROCESSES AND PROCESSES FOR THE PREPARATION OF SUCH INTERMEDIATES</title><description>The invention relates to processes for preparing compounds of the formula (1) and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R , R , R , R R , R R R , R , R , k, I, and m are as defined herein. The present invention also relates to intermediates represented by the formula (3a) wherin R , and R are independently selected from hydrogen and C1-C6 alkyl; each R , R , R and R is independently selected from hydrogen, C1-C6 alkyl and CH2OH, R and R are independently C1-C6 alkyl, and k and I are independently an integer from 1 to 3, as well as to a process for preparing these intermediates.
L'invention se rapporte à des procédés de préparation de composés de la formule (1) et à leurs sels pharmaceutiquement acceptables, à leurs promédicaments et solvates; formule dans laquelle R , R , R , R , R , R , R , R , R , R , k, l, et m sont tels que definis. La présente invention concerne également des intermédiaires représentés par la formule (3a), dans laquelle R et R sont indépendamment choisis entre hydrogène et C1-C6 alkyle; R , R , R et R sont chacun indépendamment choisis entre hydrogène, C1-C6 alkyle et CH2OH, R et R représentent indépendamment C1-C6 alkyle, et k et l représentent indépendamment un entier compris entre 1 et 3; et un procédé de préparation de ces intermédiaires.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2004</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNTrFqwzAQ9dKhpPmHgy7xYHATD8l4SGcskHWqJDt1lxCKOpXW4PxzfqNyCIRM7S3vePfuvfeYna1jQd6Th5odhIbAOrLoMCg2wDWYYpXGDk5JZQbNb0MOhW0o7dgqwzm8dsrgO-v5nBeAWicEFBSSQBJIcqpPfn0KQSPBkcZAEgS3ljsjE-thT1rPqEwg15JUSeLnfN-JBm4tZ4M_O19-7pyesofP49cUl1dcZM81BdEUcfw5xGk8fsTveDrseV2WVbnd7TYVvmz-p_oFX55ZGA</recordid><startdate>20041021</startdate><enddate>20041021</enddate><creator>VETELINO, MICHAEL, GIRARD</creator><creator>RIPIN, DAVID, HAROLD, BROWN</creator><creator>WEI, LULIN</creator><scope>EVB</scope></search><sort><creationdate>20041021</creationdate><title>PROCESSES FOR THE PREPARATION OF N-((((PYRIDINYLOXY) -PHENYLAMINO) QUINAZOLINYL)- ALLYL) ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS WELL AS INTERMEDIATES OF SUCH PROCESSES AND PROCESSES FOR THE PREPARATION OF SUCH INTERMEDIATES</title><author>VETELINO, MICHAEL, GIRARD ; RIPIN, DAVID, HAROLD, BROWN ; WEI, LULIN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2004089934A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2004</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>VETELINO, MICHAEL, GIRARD</creatorcontrib><creatorcontrib>RIPIN, DAVID, HAROLD, BROWN</creatorcontrib><creatorcontrib>WEI, LULIN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>VETELINO, MICHAEL, GIRARD</au><au>RIPIN, DAVID, HAROLD, BROWN</au><au>WEI, LULIN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PROCESSES FOR THE PREPARATION OF N-((((PYRIDINYLOXY) -PHENYLAMINO) QUINAZOLINYL)- ALLYL) ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS WELL AS INTERMEDIATES OF SUCH PROCESSES AND PROCESSES FOR THE PREPARATION OF SUCH INTERMEDIATES</title><date>2004-10-21</date><risdate>2004</risdate><abstract>The invention relates to processes for preparing compounds of the formula (1) and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R , R , R , R R , R R R , R , R , k, I, and m are as defined herein. The present invention also relates to intermediates represented by the formula (3a) wherin R , and R are independently selected from hydrogen and C1-C6 alkyl; each R , R , R and R is independently selected from hydrogen, C1-C6 alkyl and CH2OH, R and R are independently C1-C6 alkyl, and k and I are independently an integer from 1 to 3, as well as to a process for preparing these intermediates.
L'invention se rapporte à des procédés de préparation de composés de la formule (1) et à leurs sels pharmaceutiquement acceptables, à leurs promédicaments et solvates; formule dans laquelle R , R , R , R , R , R , R , R , R , R , k, l, et m sont tels que definis. La présente invention concerne également des intermédiaires représentés par la formule (3a), dans laquelle R et R sont indépendamment choisis entre hydrogène et C1-C6 alkyle; R , R , R et R sont chacun indépendamment choisis entre hydrogène, C1-C6 alkyle et CH2OH, R et R représentent indépendamment C1-C6 alkyle, et k et l représentent indépendamment un entier compris entre 1 et 3; et un procédé de préparation de ces intermédiaires.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | PROCESSES FOR THE PREPARATION OF N-((((PYRIDINYLOXY) -PHENYLAMINO) QUINAZOLINYL)- ALLYL) ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS WELL AS INTERMEDIATES OF SUCH PROCESSES AND PROCESSES FOR THE PREPARATION OF SUCH INTERMEDIATES |
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