ACYLATED PIPERAZINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR AGONISTS
Certain novel N-acylated piperazine derivatives are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the...
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| creator | BAKSHI, RAMAN, K HONG, QINGMEI SEBHAT, IYASSU, K YE, ZHIXIONG NARGUND, RAVI, P POLLARD, PATRICK, G UJJAINWALLA, FEROZE |
| description | Certain novel N-acylated piperazine derivatives are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of MC-4R, such as obesity, diabetes, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.
Selon l'invention, certains dérivés de pipérazine N-acylés sont des agonistes du ou des récepteurs de la mélanocortine humains, et, plus particulièrement, des agonistes sélectifs du récepteur de la mélanocortine 4 (MC-4R) humain. Par conséquent, ils sont utiles pour traiter, contrôler ou prévenir des maladies et des troubles réactifs à l'activation de MC-4R, tels que l'obésité, le diabète et la dysfonction sexuelle, y compris le dysfonctionnement érectile et la dysfonction sexuelle féminine. |
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Selon l'invention, certains dérivés de pipérazine N-acylés sont des agonistes du ou des récepteurs de la mélanocortine humains, et, plus particulièrement, des agonistes sélectifs du récepteur de la mélanocortine 4 (MC-4R) humain. Par conséquent, ils sont utiles pour traiter, contrôler ou prévenir des maladies et des troubles réactifs à l'activation de MC-4R, tels que l'obésité, le diabète et la dysfonction sexuelle, y compris le dysfonctionnement érectile et la dysfonction sexuelle féminine.</description><edition>7</edition><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2004</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20040916&DB=EPODOC&CC=WO&NR=2004078716A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25562,76317</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20040916&DB=EPODOC&CC=WO&NR=2004078716A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>BAKSHI, RAMAN, K</creatorcontrib><creatorcontrib>HONG, QINGMEI</creatorcontrib><creatorcontrib>SEBHAT, IYASSU, K</creatorcontrib><creatorcontrib>YE, ZHIXIONG</creatorcontrib><creatorcontrib>NARGUND, RAVI, P</creatorcontrib><creatorcontrib>POLLARD, PATRICK, G</creatorcontrib><creatorcontrib>UJJAINWALLA, FEROZE</creatorcontrib><title>ACYLATED PIPERAZINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR AGONISTS</title><description>Certain novel N-acylated piperazine derivatives are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of MC-4R, such as obesity, diabetes, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.
Selon l'invention, certains dérivés de pipérazine N-acylés sont des agonistes du ou des récepteurs de la mélanocortine humains, et, plus particulièrement, des agonistes sélectifs du récepteur de la mélanocortine 4 (MC-4R) humain. Par conséquent, ils sont utiles pour traiter, contrôler ou prévenir des maladies et des troubles réactifs à l'activation de MC-4R, tels que l'obésité, le diabète et la dysfonction sexuelle, y compris le dysfonctionnement érectile et la dysfonction sexuelle féminine.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2004</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHB2dI70cQxxdVEI8AxwDXKM8vRzVXBxDfIMcwzxDHMNVnAMVvB19XH083f2Dwrx9NM1UQhydXYNCPEPUnB09_fzDA4J5mFgTUvMKU7lhdLcDMpuriHOHrqpBfnxqcUFicmpeakl8eH-RgYGJgbmFuaGZo6GxsSpAgD5lyyw</recordid><startdate>20040916</startdate><enddate>20040916</enddate><creator>BAKSHI, RAMAN, K</creator><creator>HONG, QINGMEI</creator><creator>SEBHAT, IYASSU, K</creator><creator>YE, ZHIXIONG</creator><creator>NARGUND, RAVI, P</creator><creator>POLLARD, PATRICK, G</creator><creator>UJJAINWALLA, FEROZE</creator><scope>EVB</scope></search><sort><creationdate>20040916</creationdate><title>ACYLATED PIPERAZINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR AGONISTS</title><author>BAKSHI, RAMAN, K ; HONG, QINGMEI ; SEBHAT, IYASSU, K ; YE, ZHIXIONG ; NARGUND, RAVI, P ; POLLARD, PATRICK, G ; UJJAINWALLA, FEROZE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2004078716A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2004</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>BAKSHI, RAMAN, K</creatorcontrib><creatorcontrib>HONG, QINGMEI</creatorcontrib><creatorcontrib>SEBHAT, IYASSU, K</creatorcontrib><creatorcontrib>YE, ZHIXIONG</creatorcontrib><creatorcontrib>NARGUND, RAVI, P</creatorcontrib><creatorcontrib>POLLARD, PATRICK, G</creatorcontrib><creatorcontrib>UJJAINWALLA, FEROZE</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>BAKSHI, RAMAN, K</au><au>HONG, QINGMEI</au><au>SEBHAT, IYASSU, K</au><au>YE, ZHIXIONG</au><au>NARGUND, RAVI, P</au><au>POLLARD, PATRICK, G</au><au>UJJAINWALLA, FEROZE</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>ACYLATED PIPERAZINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR AGONISTS</title><date>2004-09-16</date><risdate>2004</risdate><abstract>Certain novel N-acylated piperazine derivatives are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of MC-4R, such as obesity, diabetes, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.
Selon l'invention, certains dérivés de pipérazine N-acylés sont des agonistes du ou des récepteurs de la mélanocortine humains, et, plus particulièrement, des agonistes sélectifs du récepteur de la mélanocortine 4 (MC-4R) humain. Par conséquent, ils sont utiles pour traiter, contrôler ou prévenir des maladies et des troubles réactifs à l'activation de MC-4R, tels que l'obésité, le diabète et la dysfonction sexuelle, y compris le dysfonctionnement érectile et la dysfonction sexuelle féminine.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | ACYLATED PIPERAZINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR AGONISTS |
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